3,445
Participants
Start Date
August 31, 2006
Primary Completion Date
June 30, 2013
Study Completion Date
June 30, 2013
Spironolactone
Spironolactone (an aldosterone antagonist) is supplied as 15 mg tablets. Drug is taken orally by subjects. The initial study drug dose is 15 mg/day (one tablet) and may be titrated up to 30 mg/day (two tablets) or 45 mg/day (three tablets). Subjects are on study drug for the duration of the trial.
Placebo
Placebo of spironolactone
IMAI Research, Buenos Aires
Instituto de Investigaciones Clinicas de Quilmes, Quilmes
Instituto de Investigaciones Clinicas de Rosario, Rosario Santa Fe
Centro de Investigaciones Clinicas del Litoral SRL, Santa Fe
L &J Clinic, Kutaisi
Policlinico Modelo de Cipoletti, Cipolletti
NYU School of Medicine, New York
St. Lukes Roosevelt, New York
Bronx-Lebanon Hospital Center, The Bronx
Soundshore Medical Center of Westchester, New Rochelle
New York Methodist Hospital, Brooklyn
Jamaica Hospital Medical Center, Jamaica
Winthrop Cardiology Associates, Mineola
Northport VA Medical Center, Northport
Lewin, Fagen, and Lown, MD, PC, Smithtown
Mid Valley Cardiology, Kingston
SUNY Upstate Medical Center, Syracuse
Syracuse VA Medical Center, Syracuse
Research Foundation State University of New York at Buffalo, Buffalo
Buffalo Heart Group, LLC, Buffalo
University of Rochester Medical Center, Rochester
Pittsburgh VA Healthcare System, Pittsburgh
Medicor Associates, Inc, Erie
Capital Area Research, Camp Hill
The Milton S. Hershey Medical Center, Hershey
Lancaster Heart and Stroke Foundation, Lancaster
Geisinger Medical Center, Danville
Drexel University College of Medicine, Philadelphia
University of Pennsylvania, Philadelphia
Thomas Jefferson University Hospital- Dept. of Family and Community Health, Philadelphia
Thomas Jefferson University, Philadelphia
Temple University Hospital, Philadelphia
Eastwick Primary Care, Philadelphia
The Reading Hospital and Medical Center, West Reading
Washington Hospital Center, Washington D.C.
Washington DC VA Hospital, Washington D.C.
Kaiser Permanente, Largo
Associates in Cardiology, PA, Silver Spring
Northwest Hospital, Randallstown
University of Maryland Medical Center, Baltimore
Sinai Hospital of Baltimore, Baltimore
Delmarva Heart Research Foundation, Salisbury
Cardiovascular Associates Ltd., Chesapeake
Sentara Cardiovascular Research Institute, Norfolk
CAMC Health Education and Research Institute, Charleston
Wake Forest University Health Sciences, Winston-Salem
Durham VA Medical Center, Durham
Northeast Medical Center, Concord
VAMC - Charleston, SC, Charleston
InnovaMed Alliance, Marietta
Emory University at Grady Health System, Atlanta
Morehouse School of Medicine, Atlanta
Northside Cardiology Center, Atlanta
Daytona Heart Group, Daytona Beach
Mayo Clinic Florida, Jacksonville
Tallahassee Research Institute, Tallahassee
University of Florida, Gainesville
M & O Clinical Research, LLC, Fort Lauderdale
Florida Heart Center, Ft. Pierce
University of Alabama at Birmingham, Birmingham
Vanderbilt Heart and Vascular Institute, Nashville
Brevard Cardiovascular Research Associates, Inc, Rockledge
Memphis VA Medical Center, Memphis
Memphis Heart Clinic, Memphis
The Stern Cardiovascular Center, Germantown
University of Tennessee Health Science Center, Memphis
Baptist Healthcare System, Inc. d/b/a Baptist Hospital East, Louisville
Ohio State University Hospital East, Columbus
University Hospitals of Cleveland/Case Western Reserve University, Cleveland
MetroHealth Medical Center, Cleveland
CCHS Clinical Research Office/ Hillcrest Hospital, Mayfield Heights
CCHS Clinical Research Office/Marymount Hospital, Garfield Heights
The Lindner Clinical Trial Center, Cincinnati
University of Cincinnati, Cincinnati
VAMC Dayton, Dayton
The Care Group, LLC, Indianapolis
Cardiovascular Research of Northwest Indiana, LLC, Munster
William Beaumont Health Center, Royal Oak
Veterans Affairs Ann Arbor Health Care System, Ann Arbor
Oakwood Hospital and Medical Center, Dearborn
Detroit VA Medical Center, Detroit
Henry Ford Hospital, Detroit
University of Iowa Hospitals and Clinics, Iowa City
William S. Middleton Memorial VA Hospital, Madison
University of Wisconsin-Madison, Madison
Aspirus Heart and Vascular Institute, Wausau
Minneapolis VA Medical Center, Minneapolis
Black Hills VA Health Care System, Fort Meade
Glacier View Cardiology, Kalispell
Cardiovascular Research Foundation, Elk Grove Village
Rush University Medical Center, Chicago
University of Illinois at Chicago Medical Center, Chicago
Northwestern University, Chicago
Heart, Lung and Vascular Institute, Peoria
HeartCare Midwest, Peoria
Heartland Regional Medical Clinic, Saint Joseph
The Creighton Cardiac Center, Omaha
Bryan LGH Heart Institute, Lincoln
Ochsner Clinic Foundation, New Orleans
Leonard J. Chabert Medical Center, Houma
Central Arkansas Veterans Healthcare System, Little Rock
Heart Clinic Arkansas, Little Rock
COR Clinical Research, Oklahoma City
Oklahoma City VA Medical Center, Oklahoma City
Oklahoma Foundation for Cardiovascular Research, Oklahoma City
Oklahoma Heart Institute, Tulsa
Dallas VA Medical Center, Dallas
Cardiovascular Research Institute of Dallas, Dallas
U.T. Southwestern Medical Center, Dallas
Tyler Cardiovascular Consultants, Tyler
DCT - APHC, LLC dba Discovery Clinical Trials, Arlington
Michael E. DeBakey VA Medical Cntr., Houston
The Methodist Hospital Research Institute, Houston
Cardiology Clinic of San Antonio, San Antonio
Wilford Hall Medical Center, Lackland City
Texas Tech University Health Sciences Center, Odessa
University of Colorado Health Sciences Center, Aurora
Cardio-Vascular Institute, Greeley
University of Utah, Salt Lake City
LDS Hospital, Murray
Carl T. Hayden VA Medical Center, Phoenix
Cardiovascular Consultants, Ltd., Glendale
Clinica Medica San Miguel, Los Angeles
CAPRI, Los Angeles
VA Medical Center West Los Angeles, Los Angeles
Mehrdad Kevin Ariani, MD, Inc., Northridge
Olive View - UCLA Medial Center, Sylmar
Cynthia Thaik, Burbank
Naval Medical Center San Diego, San Diego
Fresno VA Medical Center, Fresno
Central Coast Cardiology, Salinas
UC Davis Medical Center, Sacremento
Providence Heart and Vascular Institute, Portland
St. Charles Health System, Bend
Evergreen Healthcare, Kirkland
University of Washington, Seattle
Sound Health Research, Port Orchard
Providence St. Peter Hospital, Olympia
National Research Center for Preventitive Medicine, Moscow
Russian State Medical University, Hospital Therapy Department #1, Moscow
State Education High Professional Education Russian State Medical University, Moscow
"Federal State Institution Outpatient clinic #3 of President's Management Department of Russian Fede", Moscow
City Healthcare Institution Clinical Hospital #8, Yaroslavl
Yaroslavl Regional Clinical Hospital, Yaroslavl
Municipal Healthcare Institution <>, Gatchina
Public Institution of Health City Hospital # 28, Saint Petersburg
State Institution Saint-Petersburg Dzhanelidze Scientific, Saint Petersburg
"Saint-Petersburg State Healthcare Institution City Alexander's Hospital", Saint Petersburg
Saint-Petersburg Clinical Hospital of RAMS, policlinic department, Saint Petersburg
Almasov research institute of Cardiology, Saint Petersberg
Federal State Health Care Institution, Saint Petersburg
"Saint-Petersburg State Health Care Institution City Hospital of Saint George the Martyr", Saint Petersburg
Non-state Health Care Institution, Saint Petersburg
City Hospital #26, Saint Petersburg
City Hospital No 26, Saint Petersburg
Chair and Department of Hospital Therapy, Saint Petersburg
Medico- Military Academy, Navy Therapy Dept, Saint Petersburg
"Saint-Petersburg State Institution of Health Protection, City Hosptial # 15", Saint Petersburg
"Saint-Petersburg State Health Institution Pokrovskaya City Hospital", Saint Petersburg
Kaliningrad Region Hospital, Kaliningrad
"State Healthcare Institution Region Clinical Hospital #1", Krasnodar
"State Health Care Institution Voronezh Regional Clinical Consultative & Diagnostic Centre", Voronezh
"State Educational institution of Higher Professional Education Volgograd State Medical University o", Volgograd
Federal State Institution, Saratov
State Educational Institution of High Professional Education Saratov State Medical University, Saratov
Novosibirsk Municipal Clinical Emergency Hosp. # 2, Novosibirsk
State Institition Research Institution of Cardiology of Tomsk, Tomsk
Kemerovo Cadiologiy Dispensary, Kemerovo Medical Academy, Kemerovo
Nonstate Healthcare Institution, Kemerovo
Altay State Medical University of federal agency of public health and social progress RF, Barnaul
"Municipal Health Care Institution City Hospital #1", Barnaul
Research Institute of Physico-Chemical Medicine Center for Atheosclerosis and Laboratory, Moscow
University of Connecticut Health Center, Farmington
Howard University Hospital, Washington D.C.
Northeast Cardiology, Bangor
Brigham and Women's Hospital, Boston
Boston University Medical Center, Boston
Caritas St. Elizabeth's Medical Center, Boston
Merrimack Valley Cardiology Associates, Chelmsford
Compass Medical East Bridgewater, East Bridgewater
Pentucket Medical Associates, Haverhill
Charles River Medical Associates, Natick
Hawthorn Medical Associates, North Dartmouth
Baystate Medical Center, Springfield
Umass Memorial Medical Center, Worcester
Deborah Heart and Lung Center, Browns Mills
Cardiovascular Associates of the Delaware Valley, Elmer
Cardiovascular Associates of the Delaware Valley, Haddon Heights
NJ Heart, Linden
St. Joseph's Regional Medical Center, Paterson
The Valley Hospital, Ridgewood
Electrophysiology Research Foundation, Somerset
Community Medical Center, Toms River
New Jersey Cardiology Associates, West Orange
Memorial Hospital Rhode Island, Pawtucket
Instituto de Investigaciones Clinicas de Bahia Blanca, Bahía Blanca
CIPREC, Buenos Aires
Instituto Cardiologico Ezpecializado S.R.L, Buenos Aires
Clinica IMA, Buenos Aires
Clinica Coronel Suarez, Coronel Suárez
Hospital Italiano de La Plata, La Plata
Instituto de Investigaciones Clinicas de Mar Del Plata, Mar del Plata
Clinica Privada Del Prado, Córdoba
Hospital San Bernardo, Salta
Centro Privado de Cardiologia, San Miguel de Tucumán
Centro Modelo de Cardiología, San Miguel de Tucumán
Instituto de Cardiologia SRL, San Miguel de Tucumán
Sanatorio Mayo S.A., Santa Fe
Hospital Felicio Rocho, Belo Horizonte
Santa Casa De Belo Horizonte, Belo Horizonte
HMCP PUC Campinas, Campinas
Irmandade da Santa Casa de Misericordia de Curitiba, Curitiba Parana
Hospital das Clinicas da Universidade Federal de Goias, Goiás
Instituto do Coracao de Marilia, Marilia Sao Paulo
Hospital Sao Vicente de Paulo, Passo Fundo
PROCAPE, Pernambuco
Hospital Mae De Deus, Porto Alegre
Hospital Universitario Pedro Ernesto, Rio de Janeiro
Santa Casa de Misericordia do Rio de Janeiro, Rio de Janeiro
Instituto de Cardiologia de Santa Catarina, Santa Catarina
Incor Fmusp, São Paulo
Instituto de Molestias Cardiosvaculares, São Paulo
UNIFESP/Hospital Sao Paulo, São Paulo
Instituto do Coracao do Triangulo Mineiro, Uberlândia
Misericordia Hospital - Cardiac Sciences, Edmonton
CDRC Rive-Sud, Longueuil
SMBD Jewish General Hospital, Montreal
Saskatchewan Heart Centre, Saskatoon
Cardiology Clinical Trials - Surrey Memorial Hospital, Surrey
Centre Hospitalier de Trois-Rivieres, Trois-Rivières
Non State Health Care Institution Central Hospital #6 of Russian Railways JSC, Moscow
Chair of Nephrology and Dialysis of St Petersburg State Medical University, Saint Petersburg
Hospital de Clinicas de Porto Alegre, Porto Alegre
University of Calgary, Calgary
Fraser Clinical Trials Inc., New Westminster
St. Boniface General Hospital, Winnipeg
Health Science Centre, St. John's
Capital District Health Authority, Halifax
Dr. Saul Vizel Cardiac Research Office, Cambridge
Cornwall Clinical Trials, Cornwall
Dr. Gurcharan Syan (PP), Greater Sudbury
Hamilton Health Sciences - General Site, Hamilton
London Health Sciences Center, London
Ottawa Heart Institute, Ottawa
St. Michael's Hospital, Toronto
Mount Sinai Hospital, Toronto
CHUS - Hopital Fleurimont, Fleurimont
Service de la Recherche, Granby
Cite de la Sante de Laval, Laval
Clinique Cardiologie Levis, Lévis
Hopital Du Sacre Coeur de Montreal, Montreal
Montreal Heart Institute, Montreal
CHUM - Hotel Dieu, Montreal
Chum Hotel Dieu, Montreal
Royal Victoria Hospital, Montreal
Montreal General Hospital, Montreal
Centre de recherche clinique de Quebec, Québec
C.S.S.S.B., Saint George
Centre Hosp Regional de Lanaudiere, Sainte Charles Borromee
Hopital Laval, Ste-Foy
CSSS du Sud de Lanaudiere (Hopital Pierre-Le Gardeur), Terrebonne
Centre De Sante et De Services Sociaux De Thetford, Thetford-Mines
Cardio-Reanimation Centre, Tbilisi
Tbilisi State Medical University Clinic #1, Tbilisi
Cardiology Clinic, Tbilisi
Multiprofile Clinical Hospital of Tbilisi #2, Tbilisi
Emergency Cardiology Centre, Tbilisi
National Center of Therapy, Tbilisi
Diagnostic Services Clinic, Tbilisi
"Clinic of Angiocardiology ADAPTI", Tbilisi
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Carelon Research
OTHER