Bortezomib and Rituximab in Treating Patients With Non-Hodgkin's Lymphoma

PHASE2CompletedINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

August 31, 2004

Primary Completion Date

August 31, 2005

Conditions
Lymphoma
Interventions
DRUG

bortezomib + rituximab

"Arm I: Patients receive bortezomib IV over 3-5 seconds on days 1, 4, 8, and 11. Patients also receive rituximab IV on days 1, 8, and 15 of course 1 only and on day 1 of course 2 only. Treatment with repeats every 21 days for up to 5 courses in the absence of disease progression or unacceptable toxicity.~* Arm II: Patients receive bortezomib IV over 3-5 seconds on days 1, 8, 15 and 22. Patients also receive rituximab IV on days 1, 8, 15, and 22 of course 1 only. Treatment repeats every 35 days for up to 3 courses in the absence of disease progression or unacceptable toxicity.~Patients in either arm may crossover to the other arm if treatment is found to be ineffective."

Trial Locations (1)

90095

Jonsson Comprehensive Cancer Center at UCLA, Los Angeles

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Jonsson Comprehensive Cancer Center

OTHER

NCT00093769 - Bortezomib and Rituximab in Treating Patients With Non-Hodgkin's Lymphoma | Biotech Hunter | Biotech Hunter