9
Participants
Start Date
July 31, 2004
Primary Completion Date
January 31, 2009
Study Completion Date
January 31, 2009
17 allylamino-17-demethoxygeldanamycin
17 allylamino-17-demethoxygeldanamycin (17 AAG) given intravenously at a dose of 300 mg/m2 on days 1,8 and 15 of 28 day cycles.
18 FDG (Fludeoxyglucose 18F)
18FDG PET performed at baseline and 12 weeks after treatment. At each timepoint participants can receive 250mCi 0-15 water and 15 mCi F18-FDG.
[15-O] H2O
\[15-0\] H20 performed at baseline and 12 weeks after treatment. At each time point participants can receive 250mCi 0-15 water and 15 mCi F18-FDG. The water scans were done as several intravenous injections for several scans but not over a total of 250 mCi.
EPL diluent
17AAG is formulated with this diluent. Supplied in a 50 mL flint vial containing 48 mL of 2% egg phospholipids, and 5% dextrose in Water for Injection, USP. Patients with a history of serious allergic reactions to eggs should not receive this agent.
National Cancer Institute, National Institutes of Health, Bethesda
National Cancer Institute (NCI)
NIH