S0356 Oxaliplatin, 5-FU, Radiation Therapy (RT), Surgery for Pts With Stage II or III Cancer of Esophagus or Gastroesophageal (GE) Junction

PHASE2CompletedINTERVENTIONAL
Enrollment

98

Participants

Timeline

Start Date

September 30, 2004

Primary Completion Date

August 31, 2009

Study Completion Date

August 31, 2011

Conditions
Esophageal Cancer
Interventions
DRUG

fluorouracil

Before surgery: 180 mg/m2/day by 24-hour infusion days 8 through 43. After surgery:180 mg/m2/day by 24-hour infusion days 1 through 36.

DRUG

oxaliplatin

Before surgery: 85 mg/m2 by 2-hour IV infusion days 1, 15, and 29. After surgery: 85 mg/m2 by 2-hour IV infusion days 1, 15, and 29.

PROCEDURE

conventional surgery

The surgical technique will depend upon the location and extent of tumor and individual surgeon preference.

RADIATION

radiation therapy

Starting Day 8, patients will be treated 5 days/week at 180 centigray (cGy)/day times 25 fractions to a total dose of 4,500 cGy.

Trial Locations (143)

24273

Southwest Virginia Regional Cancer Center at Wellmonth Health, Norton

27320

Annie Penn Cancer Center, Reidsville

28139

Rutherford Hospital, Rutherfordton

28801

Mission Hospitals - Memorial Campus, Asheville

29303

CCOP - Upstate Carolina, Spartanburg

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg

29615

CCOP - Greenville, Greenville

29621

AnMed Cancer Center, Anderson

30501

Northeast Georgia Medical Center, Gainesville

37662

Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport

44307

McDowell Cancer Center at Akron General Medical Center, Akron

45177

Clinton Memorial Hospital, Wilmington

45267

Charles M. Barrett Cancer Center at University Hospital, Cincinnati

45385

Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital, Dayton

45409

David L. Rike Cancer Center at Miami Valley Hospital, Dayton

45415

Samaritan North Cancer Care Center, Dayton

45428

Veterans Affairs Medical Center - Dayton, Dayton

45429

CCOP - Dayton, Dayton

Charles F. Kettering Memorial Hospital, Kettering

45840

Blanchard Valley Medical Associates, Findlay

46107

St. Francis Hospital and Health Centers - Beech Grove Campus, Beech Grove

47374

Reid Hospital & Health Care Services, Richmond

48202

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit

49017

Battle Creek Health System Cancer Care Center, Battle Creek

49307

Mecosta County Medical Center, Big Rapids

49423

Holland Community Hospital, Holland

49442

Hackley Hospital, Muskegon

49503

Butterworth Hospital at Spectrum Health, Grand Rapids

CCOP - Grand Rapids, Grand Rapids

Lacks Cancer Center at Saint Mary's Health Care, Grand Rapids

49506

Metro Health Hospital, Grand Rapids

49684

Munson Medical Center, Traverse City

59101

CCOP - Montana Cancer Consortium, Billings

Hematology-Oncology Centers of the Northern Rockies - Billings, Billings

Northern Rockies Radiation Oncology Center, Billings

St. Vincent Healthcare Cancer Care Services, Billings

59405

Frontier Cancer Center, Great Falls

Great Falls Clinic - Main Facility, Great Falls

Sletten Cancer Institute at Benefis Healthcare, Great Falls

59601

St. Peter's Hospital, Helena

59701

St. James Healthcare Cancer Care, Butte

59715

Bozeman Deaconess Cancer Center, Bozeman

59801

Community Medical Center, Missoula

59804

Guardian Oncology and Center for Wellness, Missoula

59807

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula

59901

Glacier Oncology, PLLC, Kalispell

Kalispell Medical Oncology at KRMC, Kalispell

Kalispell Regional Medical Center, Kalispell

60153

Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood

62002

Saint Anthony's Hospital at Saint Anthony's Health Center, Alton

62526

Decatur Memorial Hospital Cancer Care Institute, Decatur

62864

Good Samaritan Regional Health Center, Mount Vernon

63141

CCOP - St. Louis-Cape Girardeau, St Louis

David C. Pratt Cancer Center at St. John's Mercy, St Louis

63701

Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital, Gape Girardeau

63703

Saint Francis Medical Center, Cape Girardeau

64131

CCOP - Kansas City, Kansas City

64804

St. John's Regional Medical Center, Joplin

65802

CCOP - Cancer Research for the Ozarks, Springfield

65804

St. John's Regional Health Center, Springfield

65807

Hulston Cancer Center at Cox Medical Center South, Springfield

66061

Olathe Cancer Center, Olathe

66606

Cotton-O'Neil Cancer Center, Topeka

St. Francis Comprehensive Cancer Center, Topeka

66720

Cancer Center of Kansas, PA - Chanute, Chanute

67042

Cancer Center of Kansas, PA - El Dorado, El Dorado

Cancer Center of Kansas, PA - Salina, Salina

67068

Cancer Center of Kansas, PA - Kingman, Kingman

67114

Cancer Center of Kansas, PA - Newton, Newton

67124

Cancer Center of Kansas, PA - Pratt, Pratt

67152

Cancer Center of Kansas, PA - Wellington, Wellington

67156

Cancer Center of Kansas, PA - Winfield, Winfield

67208

Associates in Womens Health, PA - North Review, Wichita

Cancer Center of Kansas, PA - Medical Arts Tower, Wichita

67214

Cancer Center of Kansas, PA - Wichita, Wichita

CCOP - Wichita, Wichita

Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita

Wesley Medical Center, Wichita

67357

Cancer Center of Kansas, PA - Parsons, Parsons

67801

Cancer Center of Kansas, PA - Dodge City, Dodge City

67901

Southwest Medical Center, Liberal

72712

Highlands Oncology Group - Springdale, Bentonville

76508

CCOP - Scott and White Hospital, Temple

80524

Poudre Valley Hospital, Fort Collins

82801

Welch Cancer Center at Sheridan Memorial Hospital, Sheridan

84003

American Fork Hospital, American Fork

84103

LDS Hospital, Salt Lake City

84106

Utah Cancer Specialists at UCS Cancer Center, Salt Lake City

84157

Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray

84321

Logan Regional Hospital, Logan

84403

Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center - Provo, Provo

84720

Sandra L. Maxwell Cancer Center, Cedar City

84770

Dixie Regional Medical Center - East Campus, St. George

92262

Desert Regional Medical Center Comprehensive Cancer Center, Palm Springs

94538

Valley Medical Oncology, Fremont

94546

East Bay Radiation Oncology Center, Castro Valley

Eden Medical Center, Castro Valley

Valley Medical Oncology Consultants - Castro Valley, Castro Valley

94588

Valley Care Medical Center, Pleasanton

Valley Medical Oncology Consultants - Pleasanton, Pleasanton

94602

Highland General Hospital, Oakland

94609

Alta Bates Summit Medical Center - Summit Campus, Oakland

Bay Area Breast Surgeons, Incorporated, Oakland

CCOP - Bay Area Tumor Institute, Oakland

Larry G Strieff MD Medical Corporation, Oakland

Tom K Lee, Incorporated, Oakland

94806

Doctors Medical Center - San Pablo Campus, San Pablo

95817

University of California Davis Cancer Center, Sacramento

98104

Fred Hutchinson Cancer Research Center, Seattle

Harborview Medical Center, Seattle

Minor and James Medical, PLLC, Seattle

98108

Veterans Affairs Medical Center - Seattle, Seattle

98112

Group Health Central Hospital, Seattle

98122

Polyclinic First Hill, Seattle

98225

St. Joseph Cancer Center, Bellingham

98310

Olympic Hematology and Oncology, Bremerton

99202

Cancer Care Northwest - Spokane South, Spokane

99336

Columbia Basin Hematology, Kennewick

99508

Providence Cancer Center, Anchorage

36652-2144

Mobile Infirmary Medical Center, Mobile

90089-9181

USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles

31403-3089

Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah

62781-0001

Regional Cancer Center at Memorial Medical Center, Springfield

66160-7357

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City

40536-0093

Lucille P. Markey Cancer Center at University of Kentucky, Lexington

02118

Boston University Cancer Research Center, Boston

48201-1379

Barbara Ann Karmanos Cancer Institute, Detroit

59107-7000

Billings Clinic - Downtown, Billings

59405-5309

Big Sky Oncology, Great Falls

59807-7877

Montana Cancer Specialists at Montana Cancer Center, Missoula

68848-1990

Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney

10940-4199

Tucker Center for Cancer Care at Orange Regional Medical Center, Middletown

27203-5400

Randolph Hospital, Asheboro

27403-1198

Moses Cone Regional Cancer Center at Wesley Long Community Hospital, Greensboro

45005-1066

Middletown Regional Hospital, Franklin

45373-1300

UVMC Cancer Care Center at Upper Valley Medical Center, Troy

98122-4307

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle

98195-6043

University Cancer Center at University of Washington Medical Center, Seattle

99204-2967

Rockwood Clinic Cancer Treatment Center, Spokane

98801-2028

Wenatchee Valley Medical Center, Wenatchee

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

SWOG Cancer Research Network

NETWORK

NCT00086996 - S0356 Oxaliplatin, 5-FU, Radiation Therapy (RT), Surgery for Pts With Stage II or III Cancer of Esophagus or Gastroesophageal (GE) Junction | Biotech Hunter | Biotech Hunter