115
Participants
Start Date
June 30, 2005
Primary Completion Date
November 30, 2009
Study Completion Date
November 30, 2009
paroxetine
Paroxetine 10 mg tablets or matching placebo given once a day for the first two weeks. If depression is not being effectively treated then the paroxetine or matching placebo will be increased to 20 mg, followed by a 10 mg increase every two weeks (if tolerated). Dosage for this study will not exceed 40 mg.
venlafaxine
Venlafaxine XR 37.5 mg capsules or matching placebo given once a day for the first two weeks. If depression is not being effectively treated then the venlafaxine XR capsules or matching placebo will be increased to 75 mg followed by 75 mg increments every 2 weeks (if tolerated). Dosage for this study will not exceed 225 mg.
placebo
an inactive substance
University of Rochester, Rochester
Johns Hopkins University, Baltimore
University of Maryland, Baltimore
University of Virginia, Charlottesville
Emory University School of Medicine, Atlanta
University of Florida, Gainesville
University of Miami, Miami
University of Tennessee-Memphis, Memphis
University of Kentucky, Lexington
Washington University School of Medicine, St Louis
Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston
University of California San Francisco, San Francisco
Oregon Health Sciences University, Portland
Beth Israel Deaconess Medical Center, Dept. of Neurology E/KS 430, 330 Brookline Avenue, Boston
Medical University of Ohio, Toledo
London Health Sciences Centre, University Campus Room A10-325, 339 Windermere Road, London
Hotel-Dieu Hospital-CHUM, Montreal
University of Puerto Rico, San Juan
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
University of Rochester
OTHER