Adjuvant Cetuximab and Chemoradiotherapy Using Either Cisplatin or Docetaxel in Treating Patients With Resected Stage III or Stage IV Squamous Cell Carcinoma or Lymphoepithelioma of the Head and Neck

PHASE2CompletedINTERVENTIONAL
Enrollment

238

Participants

Timeline

Start Date

April 30, 2004

Primary Completion Date

March 31, 2009

Study Completion Date

December 31, 2016

Conditions
Head and Neck Cancer
Interventions
BIOLOGICAL

cetuximab

400 mg/m\^2 intravenously over 120 minutes on day 1 (week 1) followed by 250 mg/m\^2 intravenously over 60 minutes in weeks 2 through 7.

DRUG

cisplatin

30 mg/m\^2 intravenously infused over over 60 minutes in weeks 2 through 7.

DRUG

docetaxel

15 mg/m\^2 intravenously infused over 30 minutes in weeks 2 through 7.

RADIATION

radiation therapy

60 Gy (2 Gy once a day, 5 times a week)

Trial Locations (160)

10021

Memorial Sloan-Kettering Cancer Center, New York

11201

Long Island College Hospital, Brooklyn

13210

SUNY Upstate Medical University Hospital, Syracuse

15219

Mercy Cancer Institute at Mercy Hospital, Pittsburgh

16803

Mount Nittany Medical Center, State College

17405

York Cancer Center at Apple Hill Medical Center, York

18301

Dale and Frances Hughes Cancer Center at Pocono Medical Center, East Stroudsburg

18840

Guthrie Cancer Center at Guthrie Clinic Sayre, Sayre

19001

Rosenfeld Cancer Center at Abington Memorial Hospital, Abington

19010

Bryn Mawr Hospital, Bryn Mawr

19096

CCOP - MainLine Health, Wynnewood

Lankenau Cancer Center at Lankenau Hospital, Wynnewood

19713

CCOP - Christiana Care Health Services, Newark

23249

Veterans Affairs Medical Center - Richmond, Richmond

24541

Danville Regional Medical Center, Danville

26003

Schiffler Cancer Center at Wheeling Hospital, Wheeling

27103

Forsyth Regional Cancer Center at Forsyth Medical Center, Winston-Salem

27534

Wayne Memorial Hospital, Incorporated, Goldsboro

28677

Iredell Memorial Hospital, Statesville

28801

Mission Hospitals - Memorial Campus, Asheville

29303

CCOP - Upstate Carolina, Spartanburg

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg

29425

Hollings Cancer Center at Medical University of South Carolina, Charleston

29601

Bon Secours St. Francis Health System, Greenville

29615

CCOP - Greenville, Greenville

30501

Northeast Georgia Medical Center, Gainesville

31904

John B. Amos Cancer Center, Columbus

32207

Baptist Cancer Institute - Jacksonville, Jacksonville

32224

Mayo Clinic - Jacksonville, Jacksonville

32308

Tallahassee Memorial Hospital, Tallahassee

32806

M.D. Anderson Cancer Center Orlando, Orlando

33136

University of Miami Sylvester Comprehensive Cancer Center, Miami

33140

CCOP - Mount Sinai Medical Center, Miami Beach

33308

Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital, Fort Lauderdale

33458

Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter

33486

Lynn Regional Cancer Center at Boca Raton Community Hospital - Main Center, Boca Raton

35294

University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham

37662

Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport

37916

Thompson Cancer Survival Center, Knoxville

39581

Regional Cancer Center at Singing River Hospital, Pascagoula

40504

John D. Cronin Cancer Center, Lexington

44124

Hillcrest Cancer Center at Hillcrest Hospital, Mayfield Heights

44307

McDowell Cancer Center at Akron General Medical Center, Akron

45267

Charles M. Barrett Cancer Center at University Hospital, Cincinnati

46350

Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte

46515

Elkhart General Hospital, Elkhart

46601

CCOP - Northern Indiana CR Consortium, South Bend

Memorial Hospital of South Bend, South Bend

48202

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit

48503

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

49001

Borgess Medical Center, Kalamazoo

49007

Bronson Methodist Hospital, Kalamazoo

49085

Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph, Saint Joseph

49503

CCOP - Grand Rapids, Grand Rapids

Lacks Cancer Center at Saint Mary's Health Care, Grand Rapids

49855

Upper Michigan Cancer Center at Marquette General Hospital, Marquette

52001

Wendt Regional Cancer Center at Finley Hospital, Dubuque

53226

Medical College of Wisconsin Cancer Center, Milwaukee

53405

All Saints Cancer Center at All Saints Healthcare, Racine

54143

Bay Area Cancer Care Center at Bay Area Medical Center, Marinette

54303

Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay

St. Mary's Hospital Medical Center - Green Bay, Green Bay

54601

Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse

55102

United Hospital, Saint Paul

55337

Fairview Ridges Hospital, Burnsville

55387

Ridgeview Medical Center, Waconia

55407

Virginia Piper Cancer Institute at Abbott-Northwestern Hospital, Minneapolis

55416

CCOP - Metro-Minnesota, Saint Louis Park

Park Nicollet Health Services, Saint Louis Park

55432

Mercy and Unity Cancer Center at Unity Hospital, Fridley

55433

Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55455

University of Minnesota Medical Center & Children's Hospital - Fairview, Minneapolis

55905

Mayo Clinic Cancer Center, Rochester

56303

CentraCare Clinic - River Campus, Saint Cloud

Coborn Cancer Center, Saint Cloud

57701

Rapid City Regional Hospital, Rapid City

60153

Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood

60426

Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey

62002

Saint Anthony's Hospital at Saint Anthony's Health Center, Alton

62702

Cancer Institute at St. John's Hospital, Springfield

62864

Good Samaritan Regional Health Center, Mount Vernon

63110

Siteman Cancer Center at Barnes-Jewish Hospital, St Louis

63141

CCOP - St. Louis-Cape Girardeau, St Louis

David C. Pratt Cancer Center at St. John's Mercy, St Louis

63701

Saint Francis Medical Center, Cape Girardeau

Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital, Cape Girardeau

64131

CCOP - Kansas City, Kansas City

65804

St. John's Regional Health Center, Springfield

65807

Hulston Cancer Center at Cox Medical Center South, Springfield

68114

Methodist Cancer Center at Methodist Hospital - Omaha, Omaha

76508

CCOP - Scott and White Hospital, Temple

80045

University of Colorado Cancer Center at University of Colorado Health Sciences Center, Aurora

84106

Utah Cancer Specialists at UCS Cancer Center, Salt Lake City

84107

Cottonwood Hospital Medical Center, Murray

84112

Huntsman Cancer Institute at University of Utah, Salt Lake City

84143

Latter Day Saints Hospital, Salt Lake City

84403

McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center - Provo, Provo

84770

Dixie Regional Medical Center - East Campus, St. George

85013

Arizona Oncology Services Foundation, Phoenix

85251

Virginia G. Piper Cancer Center at Scottsdale Healthcare - Osborn, Scottsdale

85260

Virginia G. Piper Cancer Center at Scottsdale Healthcare - Shea, Scottsdale

90509

Torrance Memorial Medical Center, Torrance

91505

Providence Saint Joseph Medical Center - Burbank, Burbank

92354

Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda

94609

CCOP - Bay Area Tumor Institute, Oakland

95603

Auburn Radiation Oncology, Auburn

95608

Mercy Cancer Center at Mercy San Juan Medical Center, Carmichael

95661

Radiation Oncology Center - Roseville, Roseville

95682

Radiation Oncology Centers - Cameron Park, Cameron Park

95687

Solano Radiation Oncology Center, Vacaville

95815

Radiological Associates of Sacramento Medical Group, Incorporated, Sacramento

95817

University of California Davis Cancer Center, Sacramento

95819

Mercy General Hospital, Sacramento

98101

CCOP - Virginia Mason Research Center, Seattle

98225

St. Joseph Cancer Center, Bellingham

36652-2144

Mobile Infirmary Medical Center, Mobile

85259-5499

Mayo Clinic Scottsdale, Scottsdale

91346-9600

Providence Holy Cross Cancer Center, Mission Hills

06511

Hospital of Saint Raphael, New Haven

33612-9497

H. Lee Moffitt Cancer Center and Research Institute at University of South Florida, Tampa

31403-3089

Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah

40536-0293

Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington

71315-3198

Tulane Cancer Center, Alexandria

21231-2410

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Dana-Farber/Brigham and Women's Cancer Center, Boston

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston

02118

Cancer Research Center at Boston Medical Center, Boston

02721

Hudner Oncology Center at Saint Anne's Hospital - Fall River, Fall River

48106-0995

St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital, Ann Arbor

49007-3731

West Michigan Cancer Center, Kalamazoo

55422-2900

Hubert H. Humphrey Cancer Center at North Memorial Medical Center, Robbinsdale

68848-1990

Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney

03756-0002

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon

08103

Cancer Institute of New Jersey at Cooper University Hospital - Camden, Camden

07018-1095

Veterans Affairs Medical Center - East Orange, East Orange

08053

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton

08903

Saint Peter's University Hospital, New Brunswick

08755

J. Phillip Citta Regional Cancer Center at Community Medical Center, Toms River

08043

Fox Chase Virtua Health Cancer Program at Virtua West Jersey, Voorhees Township

14263-0001

Roswell Park Cancer Institute, Buffalo

28232-2861

Blumenthal Cancer Center at Carolinas Medical Center, Charlotte

27835-6028

Leo W. Jenkins Cancer Center at ECU Medical School, Greenville

44309-2090

Akron City Hospital, Akron

43210-1240

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University, Columbus

97239-3098

Oregon Health & Science University Cancer Institute, Portland

17033-0850

Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey

19301-1792

Cancer Center of Paoli Memorial Hospital, Paoli

19107-5541

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia

19111-2497

Fox Chase Cancer Center - Philadelphia, Philadelphia

19612-6052

Reading Hospital and Medical Center, Reading

77030-4009

M.D. Anderson Cancer Center at University of Texas, Houston

23298-0037

Virginia Commonwealth University Massey Cancer Center, Richmond

98195-6043

University Cancer Center at University of Washington Medical Center, Seattle

54301-3526

Green Bay Oncology, Limited at St. Vincent Hospital, Green Bay

54307-3508

St. Vincent Hospital Regional Cancer Center, Green Bay

53792-6164

University of Wisconsin Comprehensive Cancer Center, Madison

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

NRG Oncology

OTHER

lead

Radiation Therapy Oncology Group

NETWORK