645
Participants
Start Date
January 31, 2004
Primary Completion Date
July 31, 2012
Study Completion Date
October 31, 2014
zoledronic acid
Given IV
placebo
Given IV
androgen deprivation therapy
Patients concurrently enrolled on the Phase III study of intermittent androgen deprivation in patients with stage D2 prostate cancer will receive androgen deprivation therapy per SWOG-9346. All other patients will receive androgen deprivation therapy at a standard dose and schedule throughout the study.
GnRH agonist
Patients concurrently enrolled on the Phase III study of intermittent androgen deprivation in patients with stage D2 prostate cancer will receive the GnRH agonist per SWOG-9346. All other patients will receive GnRH agonist at a standard dose and schedule throughout the study.
Calcium supplement
Patients will receive 500 mg by mouth daily of a calcium supplement or a combination tablet containing approximately 500 mg elemental calcium and 400-500 IU vitamin D by mouth daily.
Vitamin D
Patients will receive a multivitamin tablet containing 400-500 IU vitamin D by mouth daily or a combination tablet containing approximately 500 mg elemental calcium and 400-500 IU vitamin D by mouth daily.
New York Weill Cornell Cancer Center at Cornell University, New York
Kings County Hospital Center, Brooklyn
SUNY Downstate Medical Center, Brooklyn
CCOP - Hematology-Oncology Associates of Central New York, East Syracuse
SUNY Upstate Medical University Hospital, Syracuse
Veterans Affairs Medical Center - Syracuse, Syracuse
Veterans Affairs Medical Center - Buffalo, Buffalo
Susquehanna Cancer Center at Divine Providence Hospital, Williamsport
Mercy Hospital Cancer Center - Scranton, Scranton
Kaiser Permanente at Capitol Hill Medical Center, Washington D.C.
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center, Washington D.C.
Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility, Largo
Kaiser Permanente Capital Area Medical Group - Shady Grove Facility, Rockville
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore
Veterans Affairs Medical Center - Baltimore, Baltimore
Union Memorial Hospital, Baltimore
Good Samaritan Hospital of Maryland, Baltimore
Kaiser Permanente at Woodlawn Medical Center, Baltimore
Shore Regional Cancer Center at Memorial Hospital - Easton, Easton
John R. Marsh Cancer Center at Washington County Hospital, Hagerstown
Kaiser Permanente Medical Center - Fair Oaks, Fairfax
Fredericksburg Oncology, Incorporated, Fredericksburg
Lynchburg Hematology-Oncology Clinic, Lynchburg
Granville Medical Center, Oxford
Person Memorial Hospital, Roxboro
Duke Health Raleigh Hospital, Raleigh
Duke Cancer Institute, Durham
Southeastern Regional Medical Center, Lumberton
Kinston Medical Specialists, Kinston
Greenville Hospital Cancer Center, Greenville
CCOP - Greenville, Greenville
Self Regional Cancer Center at Self Regional Medical Center, Greenwood
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler, Savannah
Leesburg Regional Medical Center, Leesburg
Providence Cancer Center at Providence Hospital, Mobile
Wood County Oncology Center, Bowling Green
Flower Hospital Cancer Center, Sylvania
Fulton County Health Center, Wauseon
Toledo Hospital, Toledo
St. Vincent Mercy Medical Center, Toledo
Medical University of Ohio Cancer Center, Toledo
St. Charles Mercy Hospital, Oregon
Toledo Clinic - Oregon, Oregon
CCOP - Toledo Community Hospital, Toledo
St. Anne Mercy Hospital, Toledo
Toledo Clinic, Incorporated - Main Clinic, Toledo
MetroHealth Cancer Care Center at MetroHealth Medical Center, Cleveland
Fisher-Titus Medical Center, Norwalk
North Coast Cancer Care, Incorporated, Sandusky
Mercy Hospital of Tiffin, Tiffin
St. Rita's Medical Center, Lima
Lima Memorial Hospital, Lima
William N. Wishard Memorial Hospital, Indianapolis
Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte
Saint Anthony Memorial Health Centers, Michigan City
Michiana Hematology Oncology PC - La Porte, Westville
Michiana Hematology-Oncology, PC - Elkhart, Elkhart
Elkhart General Hospital, Elkhart
Michiana Hematology Oncology PC - Plymouth, Plymouth
CCOP - Northern Indiana CR Consortium, South Bend
Memorial Hospital of South Bend, South Bend
Howard Community Hospital, Kokomo
Community Cancer Center of Monroe, Monroe
Mercy Memorial Hospital - Monroe, Monroe
Josephine Ford Cancer Center at Henry Ford Hospital, Detroit
Borgess Medical Center, Kalamazoo
Bronson Methodist Hospital, Kalamazoo
Lakeland Regional Cancer Care Center - St. Joseph, Saint Joseph
Lakeside Cancer Specialists, PLLC, Saint Joseph
Michiana Hematology Oncology PC - Niles, Niles
Hickman Cancer Center at Bixby Medical Center, Adrian
Green Bay Oncology, Limited - Escanaba, Escanaba
Dickinson County Healthcare System, Iron Mountain
Covenant Cancer Treatment Center, Waterloo
Heartland Oncology and Hematology, Council Bluffs
Veterans Affairs Medical Center - Iowa City, Iowa City
St. Nicholas Hospital, Sheboygan
Wheaton Franciscan Cancer Care - St. Joseph, Milwaukee
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette
Green Bay Oncology, Limited - Oconto Falls, Oconto Falls
Green Bay Oncology, Limited - Sturgeon Bay, Sturgeon Bay
Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay
St. Mary's Hospital Medical Center - Green Bay, Green Bay
University of Wisconcin Cancer Center at Aspirus Wausau Hospital, Wausau
Langlade Memorial Hospital, Antigo
Riverview UW Cancer Center at Riverview Hospital, Wisconsin Rapids
Lakeview Hospital, Stillwater
Regions Hospital Cancer Care Center, Saint Paul
United Hospital, Saint Paul
HealthEast Cancer Care at St. John's Hospital, Maplewood
Minnesota Oncology Hematology, PA - Maplewood, Maplewood
Minnesota Oncology Hematology, PA - Woodbury, Woodbury
Fairview Ridges Hospital, Burnsville
Hutchinson Area Health Care, Hutchinson
Ridgeview Medical Center, Waconia
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis
Hennepin County Medical Center - Minneapolis, Minneapolis
CCOP - Metro-Minnesota, Saint Louis Park
Park Nicollet Cancer Center, Saint Louis Park
Mercy and Unity Cancer Center at Unity Hospital, Fridley
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
CCOP - Duluth, Duluth
Miller - Dwan Medical Center, Duluth
Willmar Cancer Center at Rice Memorial Hospital, Willmar
CCOP - Montana Cancer Consortium, Billings
St. Vincent Healthcare Cancer Care Services, Billings
Hematology-Oncology Centers of the Northern Rockies - Billings, Billings
Great Falls Clinic - Main Facility, Great Falls
Sletten Cancer Institute at Benefis Healthcare, Great Falls
St. Peter's Hospital, Helena
St. James Healthcare Cancer Care, Butte
Bozeman Deaconess Cancer Center, Bozeman
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula
Glacier Oncology, PLLC, Kalispell
Kalispell Medical Oncology at KRMC, Kalispell
Kalispell Regional Medical Center, Kalispell
Elmhurst Memorial Hospital, Elmhurst
Veterans Affairs Medical Center - Hines, Hines
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood
Rush-Copley Cancer Care Center, Aurora
La Grange Memorial Hospital, La Grange
Veterans Affairs Medical Center - Chicago Westside Hospital, Chicago
Louis A. Weiss Memorial Hospital, Chicago
Provena St. Mary's Regional Cancer Center - Kankakee, Kankakee
Carle Cancer Center at Carle Foundation Hospital, Urbana
CCOP - Carle Cancer Center, Urbana
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis
Cotton-O'Neil Cancer Center, Topeka
CCOP - Missouri Valley Cancer Consortium, Omaha
Methodist Estabrook Cancer Center, Omaha
Immanuel Medical Center, Omaha
Alegant Health Cancer Center at Bergan Mercy Medical Center, Omaha
Lakeside Hospital, Omaha
Cancer Resource Center - Lincoln, Lincoln
Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center, Grand Island
Callahan Cancer Center at Great Plains Regional Medical Center, North Platte
MBCCOP - LSU Health Sciences Center, New Orleans
Medical Center of Louisiana - New Orleans, New Orleans
Mary Bird Perkins Cancer Center - Baton Rouge, Baton Rouge
Highland Clinic, Shreveport
Louisiana State University Health Sciences Center - Monroe, Monroe
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center, Fort Smith
Oklahoma University Cancer Institute, Oklahoma City
Baylor University Medical Center - Houston, Houston
Ben Taub General Hospital, Houston
St. Luke's Texas Cancer Institute at St. Luke's Episcopal Hospital, Houston
Veterans Affairs Medical Center - Houston, Houston
Welch Cancer Center at Sheridan Memorial Hospital, Sheridan
American Fork Hospital, American Fork
Utah Cancer Specialists at UCS Cancer Center, Salt Lake City
Huntsman Cancer Institute at University of Utah, Salt Lake City
LDS Hospital, Salt Lake City
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray
Logan Regional Hospital, Logan
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden
Utah Valley Regional Medical Center - Provo, Provo
Sandra L. Maxwell Cancer Center, Cedar City
Dixie Regional Medical Center - East Campus, St. George
Lovelace Medical Center - Downtown, Albuquerque
University Medical Center of Southern Nevada, Las Vegas
CCOP - Nevada Cancer Research Foundation, Las Vegas
Nevada Cancer Institute, Las Vegas
Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital, Whittier
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center, Pomona
Veterans Affairs Medical Center - Loma Linda (Pettis), Loma Linda
Pismo Beach
Salinas Valley Memorial Hospital, Salinas
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Saint Helena Hospital, St. Helena
Kapiolani Medical Center at Pali Momi, ‘Aiea
Pacific Cancer Institute - Maui, Wailuku
Cancer Research Center of Hawaii, Honolulu
OnCare Hawaii, Incorporated - Lusitana, Honolulu
Queen's Cancer Institute at Queen's Medical Center, Honolulu
Straub Clinic and Hospital, Incorporated, Honolulu
Hawaii Medical Center - East, Honolulu
OnCare Hawaii, Incorporated - Kuakini, Honolulu
Kapiolani Medical Center for Women and Children, Honolulu
Kaiser Permanente Health Care - Portland, Portland
Bay Area Hospital, Coos Bay
Minor and James Medical, PLLC, Seattle
Group Health Central Hospital, Seattle
Highline Medical Center Cancer Center, Burien
University Cancer Center at University of Washington Medical Center, Seattle
Island Hospital Cancer Care Center at Island Hospital, Anacortes
St. Joseph Cancer Center, Bellingham
Skagit Valley Hospital Cancer Care Center, Mount Vernon
North Puget Oncology at United General Hospital, Sedro-Woolley
Olympic Hematology and Oncology, Bremerton
Cancer Care Northwest - Spokane South, Spokane
Evergreen Hematology and Oncology, PS, Spokane
Columbia Basin Hematology, Kennewick
Yale Cancer Center, New Haven
Veterans Affairs Medical Center - West Haven, West Haven
University of Illinois Cancer Center, Chicago
University of Chicago Cancer Research Center, Chicago
Elkhart Clinic, LLC, Elkhart
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis
Michiana Hematology-Oncology, PC - South Bend, Mishawaka
Saint Joseph Regional Medical Center, Mishawaka
Holden Comprehensive Cancer Center at University of Iowa, Iowa City
Feist-Weiller Cancer Center at Louisiana State University Health Sciences, Shreveport
Massachusetts General Hospital, Boston
Dana-Farber/Brigham and Women's Cancer Center, Boston
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute, Boston
Lowell General Hospital, Lowell
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center, Milford
West Michigan Cancer Center, Kalamazoo
Duluth Clinic Cancer Center - Duluth, Duluth
Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale
Billings Clinic - Downtown, Billings
Big Sky Oncology, Great Falls
Montana Cancer Specialists at Montana Cancer Center, Missoula
Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney
Creighton University Medical Center, Omaha
UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha
New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care, Concord
Center for Cancer Care at Exeter Hospital, Exeter
New Hampshire Oncology - Hematology, PA - Hooksett, Hooksett
Dana-Farber Cancer Institute at Londonderry, Londonderry
Elliot Regional Cancer Center at Elliot Hospital, Manchester
Veterans Affairs Medical Center - East Orange, East Orange
Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare, Vineland
University of New Mexico Cancer Center, Albuquerque
Roswell Park Cancer Institute, Buffalo
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center, Columbus
Northwest Ohio Oncology Center, Maumee
MBCCOP - Meharry Medical College - Nashville, Nashville
Mountainview Medical, Berlin Corners
Fletcher Allen Health Care - University Health Center Campus, Burlington
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle
Rockwood Clinic Cancer Treatment Center, Spokane
Wenatchee Valley Medical Center, Wenatchee
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center, Green Bay
St. Vincent Hospital Regional Cancer Center, Green Bay
Holy Family Memorial Medical Center Cancer Care Center, Manitowoc
Cross Cancer Institute at University of Alberta, Edmonton
University of British Columbia, Vancouver
London Regional Cancer Program at London Health Sciences Centre, London
Collaborators (2)
National Cancer Institute (NCI)
NIH
SWOG Cancer Research Network
NETWORK
Eastern Cooperative Oncology Group
NETWORK
NCIC Clinical Trials Group
NETWORK
Novartis Pharmaceuticals
INDUSTRY
Alliance for Clinical Trials in Oncology
OTHER