High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas

PHASE3CompletedINTERVENTIONAL
Enrollment

1

Participants

Timeline

Start Date

October 31, 2004

Primary Completion Date

September 30, 2006

Study Completion Date

September 30, 2006

Conditions
Brain TumorCentral Nervous System Tumor
Interventions
BIOLOGICAL

filgrastim

Given IV

DRUG

carboplatin

Given IV

DRUG

etoposide

Given IV

DRUG

isotretinoin

Given IV

DRUG

thiotepa

Given IV

PROCEDURE

autologous bone marrow transplantation

Peripheral blood stem cells or bone marrow will be reinfused about 72 hours following completion of the last dose of chemotherapy (Day 0)

PROCEDURE

peripheral blood stem cell transplantation

Filgrastim is to be given daily in the afternoon for 4 days prior to the first harvest and continued until the completion of the daily harvests. The daily PBSC harvesting should be started prior to the fifth dose of filgrastim.

Trial Locations (59)

6001

Princess Margaret Hospital for Children, Perth

10016

NYU Cancer Institute at New York University Medical Center, New York

10032

Herbert Irving Comprehensive Cancer Center at Columbia University, New York

10595

New York Medical College, Valhalla

13210

SUNY Upstate Medical University Hospital, Syracuse

14642

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester

22031

INOVA Fairfax Hospital, Fairfax

29425

Hollings Cancer Center at Medical University of South Carolina, Charleston

30322

Emory University Hospital - Atlanta, Atlanta

32207

Nemours Children's Clinic, Jacksonville

33136

University of Miami Sylvester Comprehensive Cancer Center, Miami

33155

Miami Children's Hospital, Miami

33407

Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach

33607

St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa

33701

All Children's Hospital, St. Petersburg

40232

Kosair Children's Hospital, Louisville

46260

St. Vincent Indianapolis Hospital, Indianapolis

48236

Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods

54449

Marshfield Clinic - Marshfield Center, Marshfield

55404

Children's Hospital of Minnesota - Minneapolis, Minneapolis

55455

Fairview University Medical Center - University Campus, Minneapolis

63110

Siteman Cancer Center at Barnes-Jewish Hospital, St Louis

64108

Children's Mercy Hospital, Kansas City

72205

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock

73104

Oklahoma University Medical Center, Oklahoma City

79410

Covenant Children's Hospital, Lubbock

95813

Cancer Research Center of Hawaii, Honolulu

95817

University of California Davis Cancer Center, Sacramento

94609-1809

Children's Hospital and Research Center - Oakland, Oakland

92123-4282

Children's Hospital and Health Center - San Diego, San Diego

80218-1088

Children's Hospital Cancer Center, Denver

20010-2970

Children's National Medical Center, Washington D.C.

32610-0232

University of Florida Shands Cancer Center, Gainesville

46202-5289

Indiana University Cancer Center, Indianapolis

04401

CancerCare of Maine at Eastern Maine Medial Center, Bangor

02111

Floating Hospital for Children at Tufts - New England Medical Center, Boston

48201-1379

Barbara Ann Karmanos Cancer Institute, Detroit

49503-2560

Spectrum Health Cancer Care - Butterworth Campus, Grand Rapids

39216-4505

University of Mississippi Medical Center, Jackson

08903

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick

14263-0001

Roswell Park Cancer Institute, Buffalo

44308-1062

Children's Hospital Medical Center of Akron, Akron

45229-3039

Cincinnati Children's Hospital Medical Center, Cincinnati

44106-5000

Rainbow Babies and Children's Hospital, Cleveland

43205-2696

Columbus Children's Hospital, Columbus

45404-1815

Children's Medical Center - Dayton, Dayton

17033-0850

Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey

57117-5039

Sioux Valley Hospital and University of South Dakota Medical Center, Sioux Falls

76104-9958

Cook Children's Medical Center - Fort Worth, Fort Worth

84113-1100

Primary Children's Medical Center, Salt Lake City

23507-1971

Children's Hospital of the King's Daughters, Norfolk

23298-0037

Massey Cancer Center at Virginia Commonwealth University, Richmond

53792-6164

University of Wisconsin Comprehensive Cancer Center, Madison

V6H 3V4

Children's & Women's Hospital of British Columbia, Vancouver

L8N 3Z5

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton

M5G 1X8

Hospital for Sick Children, Toronto

H3H 1P3

Montreal Children's Hospital at McGill University Health Center, Montreal

H3T 1C5

Hopital Sainte Justine, Montreal

G1V 4G2

Centre Hospitalier Universitaire de Quebec, Ste-Foy

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT00078988 - High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas | Biotech Hunter | Biotech Hunter