Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Low-Risk Rhabdomyosarcoma

PHASE3CompletedINTERVENTIONAL
Enrollment

390

Participants

Timeline

Start Date

September 4, 2004

Primary Completion Date

August 13, 2012

Study Completion Date

September 30, 2021

Conditions
Adult RhabdomyosarcomaEmbryonal Childhood RhabdomyosarcomaEmbryonal-botryoid Childhood RhabdomyosarcomaPreviously Untreated Childhood Rhabdomyosarcoma
Interventions
PROCEDURE

conventional surgery

Some patients may undergo second-look surgery

DRUG

dactinomycin

Given IV

DRUG

cyclophosphamide

Given IV

DRUG

vincristine sulfate

Given IV

RADIATION

radiation therapy

Undergo radiotherapy

Trial Locations (163)

1011

Swiss Pediatric Oncology Group - Lausanne, Lausanne

1145

Starship Children's Hospital, Grafton

1205

Swiss Pediatric Oncology Group - Geneva, Geneva

2031

Sydney Children's Hospital, Randwick

2145

The Children's Hospital at Westmead, Sydney

Sydney West Area Health Service-Westmead Hospital, Westmead

3052

Royal Children's Hospital, Parkville

4029

Royal Brisbane and Women's Hospital, Herston

5006

Women's and Children's Hospital-Adelaide, North Adelaide

6008

Princess Margaret Hospital for Children, Perth

8011

Christchurch Hospital, Christchurch

10029

Mount Sinai Medical Center, New York

10032

Columbia University Medical Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10595

New York Medical College, Valhalla

11040

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park

11201

Brooklyn Hospital Center, Brooklyn

12208

Albany Medical Center, Albany

13210

State University of New York Upstate Medical University, Syracuse

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

15224

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17033

Penn State Hershey Children's Hospital, Hershey

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

19104

Children's Hospital of Philadelphia, Philadelphia

19134

Saint Christopher's Hospital for Children, Philadelphia

20010

Children's National Medical Center, Washington D.C.

21215

Sinai Hospital of Baltimore, Baltimore

22042

Inova Fairfax Hospital, Falls Church

22908

University of Virginia, Charlottesville

23298

Virginia Commonwealth University, Richmond

23507

Childrens Hospital-King's Daughters, Norfolk

25304

West Virginia University Charleston, Charleston

27157

Wake Forest University Health Sciences, Winston-Salem

27599

University of North Carolina, Chapel Hill

28204

Presbyterian Hospital, Charlotte

28801

Mission Hospitals Inc, Asheville

29425

Medical University of South Carolina, Charleston

29605

Greenville Cancer Treatment Center, Greenville

30322

Children's Healthcare of Atlanta - Egleston, Atlanta

31403

Memorial Health University Medical Center, Savannah

32504

Nemours Children's Clinic - Pensacola, Pensacola

32806

M D Anderson Cancer Center- Orlando, Orlando

33021

Memorial Healthcare System - Joe DiMaggio Children's Hospital, Hollywood

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33155

Miami Children's Hospital, Miami

33176

Baptist Hospital of Miami, Miami

33316

Broward Health Medical Center, Fort Lauderdale

33407

Saint Mary's Hospital, West Palm Beach

33607

Saint Joseph Children's Hospital of Tampa, Tampa

33701

All Children's Hospital, St. Petersburg

35294

University of Alabama at Birmingham, Birmingham

37232

Vanderbilt-Ingram Cancer Center, Nashville

37403

T C Thompson Children's Hospital, Chattanooga

37916

East Tennessee Childrens Hospital, Knoxville

38105

St. Jude Children's Research Hospital, Memphis

39216

University of Mississippi Medical Center, Jackson

40202

Kosair Children's Hospital, Louisville

40536

University of Kentucky, Lexington

43205

Nationwide Children's Hospital, Columbus

44106

Rainbow Babies and Childrens Hospital, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

44308

Children's Hospital Medical Center of Akron, Akron

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

45404

The Children's Medical Center of Dayton, Dayton

46202

Indiana University Medical Center, Indianapolis

48073

William Beaumont Hospital, Royal Oak

48109

C S Mott Children's Hospital, Ann Arbor

48202

Wayne State University, Detroit

48502

Hurley Medical Center, Flint

48910

Michigan State University - Breslin Cancer Center, Lansing

49503

Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids

50309

Raymond Blank Children's Hospital, Des Moines

52242

University of Iowa Hospitals and Clinics, Iowa City

53226

Midwest Children's Cancer Center, Milwaukee

53792

University of Wisconsin Hospital and Clinics, Madison

54301

Saint Vincent Hospital, Green Bay

55404

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55455

University of Minnesota Medical Center-Fairview, Minneapolis

55905

Mayo Clinic, Rochester

60068

Advocate Lutheran General Hospital, Park Ridge

60453

Advocate Hope Children's Hospital, Oak Lawn

60612

University of Illinois, Chicago

60614

Childrens Memorial Hospital, Chicago

61602

Saint Jude Midwest Affiliate, Peoria

62702

Southern Illinois University, Springfield

63104

Cardinal Glennon Children's Medical Center, St Louis

63110

Washington University School of Medicine, St Louis

64108

The Childrens Mercy Hospital, Kansas City

68114

Children's Hospital and Medical Center of Omaha, Omaha

68198

University of Nebraska Medical Center, Omaha

70112

Tulane University Health Sciences Center, New Orleans

70118

Children's Hospital-Main Campus, New Orleans

72205

University of Arkansas for Medical Sciences, Little Rock

75230

Medical City Dallas Hospital, Dallas

75390

University of Texas Southwestern Medical Center, Dallas

76104

Cook Children's Medical Center, Fort Worth

76508

Scott and White Memorial Hospital, Temple

77030

Baylor College of Medicine, Houston

M D Anderson Cancer Center, Houston

78229

Methodist Children's Hospital of South Texas, San Antonio

78411

Driscoll Children's Hospital, Corpus Christi

79410

Covenant Children's Hospital, Lubbock

80045

Children's Hospital Colorado, Aurora

80218

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver

83712

Saint Luke's Mountain States Tumor Institute, Boise

84113

Primary Children's Medical Center, Salt Lake City

85016

Phoenix Childrens Hospital, Phoenix

85724

University of Arizona Health Sciences Center, Tucson

87106

University of New Mexico Cancer Center, Albuquerque

89106

Nevada Cancer Research Foundation CCOP, Las Vegas

90027

Children's Hospital Los Angeles, Los Angeles

90048

Cedars-Sinai Medical Center, Los Angeles

90242

Southern California Permanente Medical Group, Downey

90806

Miller Children's Hospital, Long Beach

92123

Rady Children's Hospital - San Diego, San Diego

92354

Loma Linda University Medical Center, Loma Linda

94143

University of California San Francisco Medical Center-Parnassus, San Francisco

94304

Lucile Packard Children's Hospital Stanford University, Palo Alto

94611

Kaiser Permanente-Oakland, Oakland

95817

UC Davis Comprehensive Cancer Center, Sacramento

96813

University of Hawaii, Honolulu

96859

Tripler Army Medical Center, Honolulu

97227

Legacy Emanuel Hospital and Health Center, Portland

97239

Oregon Health and Science University, Portland

98105

Seattle Children's Hospital, Seattle

99204

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

91006-3776

Children's Oncology Group, Arcadia

93636-8762

Children's Hospital Central California, Madera

94609-1809

Children's Hospital and Research Center at Oakland, Oakland

92868-3874

Childrens Hospital of Orange County, Orange

06106

Connecticut Children's Medical Center, Hartford

32207-8426

Nemours Children's Clinic - Jacksonville, Jacksonville

60637-1470

University of Chicago Comprehensive Cancer Center, Chicago

04401

Eastern Maine Medical Center, Bangor

04074

Maine Children's Cancer Program, Scarborough

21201-1595

University of Maryland Greenebaum Cancer Center, Baltimore

21287-8936

Johns Hopkins University, Baltimore

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Dana-Farber Cancer Institute, Boston

01199

Baystate Medical Center, Springfield

03756

Dartmouth Hitchcock Medical Center, Lebanon

07601

Hackensack University Medical Center, Hackensack

08903

UMDNJ - Robert Wood Johnson University Hospital, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

10467-2490

Montefiore Medical Center, The Bronx

17822-2001

Geisinger Medical Center, Danville

78229-3900

University of Texas Health Science Center at San Antonio, San Antonio

05401

University of Vermont, Burlington

T3B 6A8

Alberta Children's Hospital, Calgary

T6G 2B7

University of Alberta Hospital, Edmonton

V6H 3V4

British Columbia Children's Hospital, Vancouver

R3E 0V9

CancerCare Manitoba, Winnipeg

A1B 3V6

Janeway Child Health Centre, St. John's

L8S 4L8

Chedoke-McMaster Hospitals, Hamilton

K7L 5P9

Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston

K1H 8L1

Children's Hospital of Eastern Ontario, Ottawa

M5G 1X8

Hospital for Sick Children, Toronto

H3H 1P3

The Montreal Children's Hospital of the MUHC, Montreal

H3T 1C5

Hospital Sainte-Justine, Montreal

G1V 4G2

Centre Hospitalier Universitaire de Quebec, Ste-Foy

S4T 7T1

Allan Blair Cancer Centre, Regina

00912

San Jorge Children's Hospital, Santurce

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT00075582 - Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Low-Risk Rhabdomyosarcoma | Biotech Hunter | Biotech Hunter