43
Participants
Start Date
September 30, 2003
Primary Completion Date
March 31, 2007
Study Completion Date
December 31, 2016
filgrastim
During induction therapy, patients ≤ 70 kg will receive 300 μg OR patients \>70 kg will receive 480 μg subcutaneously on days 6-15 and 34-42.
pegfilgrastim
During induction therapy, patients receive 6 mg subcutaneously on days 6 and 34.
cisplatin
During induction therapy, patients receive 15 mg/m\^2/day by IV over 1 hour on days 1-5 and 29-33. During radiotherapy, patients receive 15 mg/m\^2/day by IV over 1 hour beginning on days 57-61.
fluorouracil
During induction therapy, patients receive 650 mg/m\^2/day by IV continuously over 96 hours beginning on days 1 and 29. During radiotherapy, patients receive 300 mg/m\^2/day by IV continuously over 96 hours beginning on day 57 for 5 cycles.
paclitaxel
During induction therapy, patients receive 200 mg/m\^2/day by IV over 2 hours on days 1 and 29.
conventional surgery
Patients with residual or recurrent esophageal disease 4-6 weeks after completion of chemoradiotherapy may undergo salvage esophagectomy.
radiation therapy
External beam radiotherapy with megavoltage linear accelerators (\> 6 MV) will be used to deliver multiple (\> 2) field techniques. Patients will be treated 5 days/week at 1.8 Gy/day for 28 days for a total dose of 50.4 Gy.
SUNY Downstate Medical Center, Brooklyn
Bryn Mawr Hospital, Bryn Mawr
Delaware County Regional Cancer Center at Delaware County Memorial Hospital, Drexel Hill
CCOP - MainLine Health, Wynnewood
Lankenau Cancer Center at Lankenau Hospital, Wynnewood
Albert Einstein Cancer Center, Philadelphia
Schiffler Cancer Center at Wheeling Hospital, Wheeling
Wayne Memorial Hospital, Incorporated, Goldsboro
Wayne Radiation Oncology, Goldsboro
Wilmed Radiation Oncology Services, Wilson
Rutherford Hospital, Rutherfordton
CCOP - Upstate Carolina, Spartanburg
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg
Rose Ramer Cancer Clinic at Anderson Area Medical Center, Anderson
Gulf Coast Cancer Treatment Center, Panama City
Baptist-South Miami Regional Cancer Program, Miami
Hattiesburg Clinic, P.A., Hattiesburg
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford, Salem
Cancer Treatment Center, Wooster
Middletown Regional Hospital, Middletown
Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia
Grandview Hospital, Dayton
Good Samaritan Hospital, Dayton
David L. Rike Cancer Center at Miami Valley Hospital, Dayton
Samaritan North Cancer Care Center, Dayton
Veterans Affairs Medical Center - Dayton, Dayton
CCOP - Dayton, Dayton
Charles F. Kettering Memorial Hospital, Kettering
St. Francis Hospital and Health Centers - Beech Grove Campus, Beech Grove
St. John Macomb Hospital, Warren
CCOP - Michigan Cancer Research Consortium, Ann Arbor
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods
Genesys Hurley Cancer Institute, Flint
Seton Cancer Institute - Saginaw, Saginaw
Sparrow Regional Cancer Center, Lansing
Foote Hospital, Jackson
Green Bay Oncology, Limited - Escanaba, Escanaba
Green Bay Oncology, Limited - Iron Mountain, Iron Mountain
Wendt Regional Cancer Center at Finley Hospital, Dubuque
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette
Green Bay Oncology, Limited - Oconto Falls, Oconto Falls
Green Bay Oncology, Limited - Sturgeon Bay, Sturgeon Bay
Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay
St. Mary's Hospital Medical Center - Green Bay, Green Bay
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse
United Hospital, Saint Paul
Fairview Ridges Hospital, Burnsville
Ridgeview Medical Center, Waconia
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital, Minneapolis
CCOP - Metro-Minnesota, Saint Louis Park
Park Nicollet Health Services, Saint Louis Park
Mercy and Unity Cancer Center at Unity Hospital, Fridley
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
Mount Sinai Hospital Medical Center, Chicago
Siteman Cancer Center at Barnes-Jewish Hospital, St Louis
CCOP - Cancer Research for the Ozarks, Springfield
St. John's Regional Health Center, Springfield
Hulston Cancer Center at Cox Medical Center South, Springfield
CCOP - Ochsner, New Orleans
University of Colorado Cancer Center at University of Colorado Health Sciences Center, Aurora
Utah Cancer Specialists at UCS Cancer Center, Salt Lake City
Cottonwood Hospital Medical Center, Murray
Huntsman Cancer Institute at University of Utah, Salt Lake City
LDS Hospital, Salt Lake City
McKay-Dee Hospital Center, Ogden
Utah Valley Regional Medical Center - Provo, Provo
Dixie Regional Medical Center - East Campus, St. George
Albuquerque Regional Medical Center at Lovelace Sandia Health System, Albuquerque
University Medical Center of Southern Nevada, Las Vegas
CCOP - Nevada Cancer Research Foundation, Las Vegas
Providence Saint Joseph Medical Center - Burbank, Burbank
Saint Rose Hospital, Hayward
Valley Care Medical Center, Pleasanton
CCOP - Bay Area Tumor Institute, Oakland
Summit Medical Center, Oakland
J.C. Robinson, M.D. Regional Cancer Center, San Pablo
Ochsner Clinic of Baton Rouge, Baton Rouge
Providence Holy Cross Cancer Center, Mission Hills
Hospital of Saint Raphael, New Haven
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital, Ann Arbor
Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn
Hubert H. Humphrey Cancer Center at North Memorial Medical Center, Robbinsdale
Monmouth Medical Center, Long Branch
Fox Chase Virtua Health Cancer Program - Marlton, Marlton
Booker Cancer Center at Riverview Medical Center, Red Bank
Community Regional Cancer Center at Community Medical Center, Toms River
University of New Mexico Cancer Research and Treatment Center, Albuquerque
Akron City Hospital, Akron
UVMC Cancer Care Center at Upper Valley Medical Center, Troy
Paoli Memorial Hospital, Paoli
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia
Fox Chase Cancer Center, Philadelphia
M.D. Anderson Cancer Center at University of Texas, Houston
Green Bay Oncology, Limited at St. Vincent Hospital, Green Bay
St. Vincent Hospital Regional Cancer Center, Green Bay
Collaborators (1)
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER
Radiation Therapy Oncology Group
NETWORK