Effects of MEDI-522 On Disease Activity and Progression of Joint Damage in Patients With Active Rheumatoid Arthritis Suboptimally Responding to Methotrexate

PHASE2CompletedINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

September 30, 2003

Study Completion Date

April 30, 2006

Conditions
Rheumatoid Arthritis
Interventions
BIOLOGICAL

MEDI-522

MEDI-522 is formulated in a sterile isotonic solution of 10 mM histidine-HCl at pH 6 containing 100 mg of MEDI-522 protein at a concentration of 100 mg/mL.

OTHER

Placebo

Placebo for MEDI-522 contains 10 mM histidine-HCl at pH 6, 0.1% Tween-80, 1.5% Mannitol, 4.3 µg/mL Vitamin B12, and 2 µg/mL D\&C Yellow #10.

Trial Locations (40)

12206

The Center for Rheumatology, Albany

20902

Center for Rheumatology and Bone Research, Wheaton

30033

Sanford S. Hartman, Decatur

33180

Arthritis and Rheumatic Disease Specialty, Aventura

33334

Centre for Rheumatology, Immunology & Arthritis, Fort Lauderdale

34239

Sarasota Arthritis Research Center, Sarasota

34474

Ocala Rheumatology Research Center, Ocala

54601

Gundersen Clinic Ltd., La Crosse

63131

RIMA, St Louis

63141

Arthritis Consultants, Inc., St Louis

72703

Fayetteville Diagnostic Clinic, Ltd., Fayetteville

73109

Health Research Institute, Oklahoma City

73112

Lynn Health Science Institute, Oklahoma City

74114

Oklahoma Center for Arthritis Therapy and Research Inc., Tulsa

75235

Radiant Research, Dallas

79124

Amarillo Center for Clinical Research, Amarillo

79410

Arthritis & Osteoporosis Associates, LLP, Lubbock

84132

University of Utah Medical Hospital, Salt Lake City

85012

Arizona Research & Education, Phoenix

85308

Sun Valley Arthritis Center, Glendale

85724

University of Arizona, Tucson

91730

Boling Clinical Trials, Rancho Cucamonga

93454

Pacific Arthritis Center Medical Group, Santa Maria

98902

Rheumatology Northwest/Clinical Trials Northwest, Yakima

99204

The Physician's Clinic of Spokane, Spokane

35249-7201

The University of Alabama at Birmingham, Birmingham

92037-0943

Thornton Hospital, La Jolla

07666

Rheumatology Associates of New Jersey, Teaneck

53792-3244

University of Wisconsin Hospital & Clinics, Madison

V7C 5L9

Richmond Health Science Center, Richmond

R3A 1M1

Manitoba Clinic, Winnipeg

R3A 1M4

Arthritis Centre, Winnipeg

R3N OK6

Centre Inflammatory Arthritis Disease Studies, Winnipeg

L8N 1Y2

Charlton Medical Center, Hamilton

L8N 2B6

MAC Research, Inc., Hamilton

N2M 5N6

K-W Musculoskeletal Research, Inc., Kitchener

L3Y 3R7

The Arthritis Program Research Group Inc., Newmarket

K1H 8L6

Ottawa General Hospital, Ottawa

H3Z 2Z3

Rheumatic Disease Center of Montreal, Montreal

S7K 0H6

Midtown Medical Center, Saskatoon

Sponsors

Lead Sponsor

All Listed Sponsors
lead

MedImmune LLC

INDUSTRY