19
Participants
Start Date
July 31, 2004
Primary Completion Date
April 30, 2007
bleomycin sulfate
Given IV over 10 minutes. Children ≥ 12 months: 15 units/m2/dose Children \< 12 months: 0.5 units/kg/dose Day 1 (Week 1, 4, 7, 10)
filgrastim
Given SQ once daily 5 micrograms/kg/dose Starting on Day 6 (Week 1, 4, 7, 10) Daily until ANC \> 5,000/uL
cisplatin
Children ≥ 12 months: Given IV over one hour Dose: 20 mg/m2/dose Days 1-5 (Week 1,4,7,10) Children \< 12 months: Given IV over 4 hours, 0.67 mg/kg/dose Days 1-5 (Week 1,4,7,10)
cyclophosphamide
Given IV over 1 hour. Children ≥ 12 months: Level 1: 1.2 g/m2/dose Level 2: 1.8 g/m2/dose Level 3: 2.4 g/m2/dose Children \< 12 months: Level 1: 40 mg/kg/dose Level 2: 60 mg/kg/dose Level 3: 80 mg/kg/dose Day 1 (Week 1, 4, 7, 10)
etoposide
Given IV over 1 hour. Children ≥ 12 months: 100 mg/m2/dose Children \< 12 months: 3.3 mg/kg/dose Day 1-5 (Week 1, 4, 7, 10)
conventional surgery
Stage III/IV extragonadal tumors: biopsy followed by a definitive surgical excision after maximal chemotherapy effect, likely after 4 cycles of therapy
MESNA
Given IV or oral. The total daily MESNA dose is equal to at least 80% of the daily CPM dose. The oral dose of MESNA is 2x the IV dose. Day 1 (Week 1,4,7,10) To be given with CPM.
Princess Margaret Hospital for Children, Perth
Albert Einstein Cancer Center at Albert Einstein College of Medicine, The Bronx
New York Medical College, Valhalla
SUNY Upstate Medical University Hospital, Syracuse
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester
Alfred I. duPont Hospital for Children, Wilmington
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore
INOVA Fairfax Hospital, Fairfax
Carilion Cancer Center of Western Virginia, Roanoke
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division, Charleston
Duke Comprehensive Cancer Center, Durham
Hollings Cancer Center at Medical University of South Carolina, Charleston
Greenville Hospital System Cancer Center, Greenville
Emory University Hospital - Atlanta, Atlanta
Nemours Children's Clinic, Jacksonville
Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola
University of Miami Sylvester Comprehensive Cancer Center, Miami
Miami Children's Hospital, Miami
Baptist-South Miami Regional Cancer Program, Miami
Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach
St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa
All Children's Hospital, St. Petersburg
Lee Cancer Care of Lee Memorial Health System, Fort Myers
Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham
East Tennessee Children's Hospital, Knoxville
St. Jude Children's Research Hospital, Memphis
Tod Children's Hospital - Forum Health, Youngstown
St. Vincent Indianapolis Hospital, Indianapolis
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods
Hurley Medical Center, Flint
Breslin Cancer Center at Ingham Regional Medical Center, Lansing
Midwest Children's Cancer Center, Milwaukee
Marshfield Clinic - Marshfield Center, Marshfield
Children's Hospital of Minnesota - Minneapolis, Minneapolis
Fairview University Medical Center - University Campus, Minneapolis
Mayo Clinic Cancer Center, Rochester
Children's Memorial Hospital - Chicago, Chicago
Saint Jude Midwest Affiliate, Peoria
Siteman Cancer Center at Barnes-Jewish Hospital, St Louis
Children's Mercy Hospital, Kansas City
Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock
Oklahoma University Medical Center, Oklahoma City
Medical City Dallas Hospital, Dallas
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas
Driscoll Children's Hospital, Corpus Christi
Children's Hospital of Austin, Austin
Texas Tech University Health Sciences Center School of Medicine, Amarillo
Covenant Children's Hospital, Lubbock
Children's Hospital Los Angeles, Los Angeles
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
Stanford Cancer Center at Stanford University Medical Center, Stanford
Cancer Research Center of Hawaii, Honolulu
Kaiser Permanente Medical Center - Oakland, Sacramento
Phoenix Children's Hospital, Phoenix
Southern California Permanente Medical Group, Downey
Children's Hospital Central California, Madera
Children's Hospital and Health Center - San Diego, San Diego
Children's Hospital Cancer Center, Denver
Children's National Medical Center, Washington D.C.
University of Florida Shands Cancer Center, Gainesville
Southern Illinois University School of Medicine, Springfield
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City
Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington
CancerCare of Maine at Eastern Maine Medial Center, Bangor
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston
C.S. Mott Children's Hospital at University of Michigan, Ann Arbor
Barbara Ann Karmanos Cancer Institute, Detroit
Spectrum Health Cancer Care - Butterworth Campus, Grand Rapids
University of Mississippi Medical Center, Jackson
Hackensack University Medical Center Cancer Center, Hackensack
St. Barnabas Medical Center, Livingston
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Children's Medical Center - Dayton, Dayton
Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey
Children's Hospital of Philadelphia, Philadelphia
St. Christopher's Hospital for Children, Philadelphia
Cook Children's Medical Center - Fort Worth, Fort Worth
Baylor University Medical Center - Houston, Houston
M.D. Anderson Cancer Center at University of Texas, Houston
University of Texas Health Science Center at San Antonio, San Antonio
Methodist Children's Hospital of South Texas, San Antonio
Primary Children's Medical Center, Salt Lake City
St. Vincent Hospital Regional Cancer Center, Green Bay
University of Wisconsin Comprehensive Cancer Center, Madison
Children's & Women's Hospital of British Columbia, Vancouver
Janeway Children's Health and Rehabilitation Centre, St. John's
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Hospital for Sick Children, Toronto
Montreal Children's Hospital at McGill University Health Center, Montreal
Hopital Sainte Justine, Montreal
Centre Hospitalier Universitaire de Quebec, Ste-Foy
Allan Blair Cancer Centre at Pasqua Hospital, Regina
San Jorge Children's Hospital, Santurce
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK