743
Participants
Start Date
July 31, 2002
Primary Completion Date
June 30, 2010
Study Completion Date
May 20, 2022
cisplatin
100 mg/m\^2 intravenously on days 1, 22
Standard fractionation RT
Radiation will be delivered in 2 Gy per fraction, five fractions a week. The primary tumor and clinically/radiologically involved nodes will receive 70 Gy in 7 weeks and uninvolved nodes will receive 50 Gy in 5 weeks. The anterior lower neck field will be treated with 2 Gy per fraction at 3-cm depth to a total dose of 50 Gy.
Accelerated fractionation radiation therapy
Radiation to the initial target volume encompassing the gross and subclinical disease sites will be delivered in 1.8 Gy per fraction, five fractions a week to 54 Gy in 30 fractions over 6 weeks. At 32.4 Gy/18 Fx (i.e., latter part of week 4), the boost volume covering gross tumor and clinically/radiologically involved nodes will receive boost irradiation of 1.5 Gy/Fx as second daily fraction (at least 6 h interval) for a total of 12 treatment days (18 Gy total). The primary tumor and clinically/radiologically involved nodes will receive 72 Gy in 42 fractions over 6 weeks and uninvolved nodes will receive 54 Gy in 6 weeks. Clinically/radiologically negative posterior neck should receive a minimum dose of 50.4 Gy at 3 cm. The anterior lower neck field will be treated with 1.8 Gy per fraction at 3-cm depth to a total dose of 50.4 Gy in 28 fractions in 5.6 weeks.
Conventional surgery for select patients
"Surgical removal (salvage resection) of the primary tumor should be performed if biopsy-proven cancer remains more than three months after completion of therapy. The nature of the surgical resection should be dictated by the extent of tumor at the initial evaluation. The operation should be conducted using accepted criteria for primary surgical treatment of the cancer.~A planned neck dissection for patients with multiple neck nodes or with lymph nodes exceeding 3 cm in diameter (N2a, N2b, N3) is mandatory, regardless of the clinical and/or radiographic response. A neck dissection is required for patients with N1 disease if a palpable or worrisome radiographic abnormality persists in the neck six weeks after completion of therapy. Surgery should be performed within 2 weeks once the decision for neck dissection is made."
CCOP - North Shore University Hospital, Manhasset
New York Methodist Hospital, Brooklyn
Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center, Plattsburgh
SUNY Upstate Medical University Hospital, Syracuse
Roswell Park Cancer Institute, Buffalo
Mercy Hospital of Pittsburgh, Pittsburgh
Mercy Hospital Cancer Center - Scranton, Scranton
Abington Memorial Hospital, Abington
Bryn Mawr Hospital, Bryn Mawr
CCOP - MainLine Health, Wynnewood
Lankenau Cancer Center at Lankenau Hospital, Wynnewood
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia
Albert Einstein Cancer Center, Philadelphia
Cancer Center at Paoli Memorial Hospital, Paoli
CCOP - Christiana Care Health Services, Newark
St. Francis Hospital, Wilmington
Beebe Medical Center, Lewes
DeCesaris Cancer Institute at Anne Arundel Medical Center, Annapolis
Union Hospital Cancer Center at Union Hospital, Elkton
Rappahannock General Hospital, Kilmarnock
Veterans Affairs Medical Center - Richmond, Richmond
Danville Regional Medical Center, Danville
Schiffler Cancer Center at Wheeling Hospital, Wheeling
Comprehensive Cancer Center at Wake Forest University, Winston-Salem
Randolph Hospital, Asheboro
John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital, Eden
Annie Penn Cancer Center, Reidsville
Moses Cone Regional Cancer Center at Wesley Long Community Hospital, Greensboro
Wayne Memorial Hospital, Incorporated, Goldsboro
Wayne Radiation Oncology, Goldsboro
Wilson Medical Center, Wilson
Rutherford Hospital, Rutherfordton
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg
CCOP - Upstate Carolina, Spartanburg
Bon Secours St. Francis Health System, Greenville
Greenville Hospital System Cancer Center, Greenville
CCOP - Greenville, Greenville
Rose Ramer Cancer Clinic at Anderson Area Medical Center, Anderson
Georgia Cancer Center for Excellence at Grady Memorial Hospital, Atlanta
Emory University Hospital - Atlanta, Atlanta
Northeast Georgia Medical Center, Gainesville
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah
John B. Amos Community Cancer Center, Columbus
Baptist Cancer Institute - Jacksonville, Jacksonville
University of Florida Shands Cancer Center, Jacksonville
Gulf Coast Cancer Treatment Center, Panama City
Shands Cancer Center at the University of Florida - Jacksonville, Gainesville
Memorial Cancer Institute at Memorial Regional Hospital, Hollywood
CCOP - Mount Sinai Medical Center, Miami Beach
Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital, Fort Lauderdale
Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida, Tampa
21st Century Oncology - Fort Myers, Fort Myers
Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham
Mobile Infirmary Medical Center, Mobile
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center, Nashville
James Graham Brown Cancer Center at University of Louisville, Louisville
Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington
Cancer Treatment Center at the Medical Center - Bowling Green, Bowling Green
Akron City Hospital at Summa Health System, Akron
McDowell Cancer Center at Akron General Medical Center, Akron
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford, Salem
Cancer Treatment Center, Wooster
Middletown Regional Hospital, Middletown
UVMC Cancer Care Center at Upper Valley Medical Center, Troy
Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia
Grandview Hospital, Dayton
Good Samaritan Hospital, Dayton
Miami Valley Hospital, Dayton
Samaritan North Cancer Care Center, Dayton
Veterans Affairs Medical Center - Dayton, Dayton
CCOP - Dayton, Dayton
Charles F. Kettering Memorial Hospital, Kettering
St. Rita's Medical Center, Lima
St. John's Cancer Center at St. John's Medical Center, Anderson
St. Francis Hospital and Health Centers, Beech Grove
Indiana University Cancer Center, Indianapolis
Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte
Elkhart General Hospital, Elkhart
Saint Joseph Regional Medical Center - Plymouth Campus, Plymouth
CCOP - Northern Indiana CR Consortium, South Bend
Memorial Hospital of South Bend, South Bend
CCOP - Michigan Cancer Research Consortium, Ann Arbor
Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn
Van Elslander Cancer Center at St. John Hospital and Medical Center, Detroit
Hurley Medical Center, Flint
Genesys Hurley Cancer Institute, Flint
Great Lakes Cancer Institute at McLaren Regional Medical Center, Flint
Seton Cancer Institute - Saginaw, Saginaw
St. John Macomb Hospital, Warren
Borgess Medical Center, Kalamazoo
CCOP - Kalamazoo, Kalamazoo
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Wendt Regional Cancer Center at Finley Hospital, Dubuque
Community Memorial Hospital, Menomonee Falls
Waukesha Memorial Hospital Regional Cancer Center, Waukesha
St. Mary's Cancer Center at Columbia St. Mary's Hospital - Milwaukee Campus, Milwaukee
Medical College of Wisconsin Cancer Center, Milwaukee
Veterans Affairs Medical Center - Milwaukee (Zablocki), Milwaukee
All Saints Cancer Center at All Saints Healthcare, Racine
University of Wisconsin Comprehensive Cancer Center, Madison
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette
Holy Family Memorial Medical Center, Manitowoc
St. Vincent Hospital, Green Bay
Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay
St. Mary's Hospital Medical Center, Green Bay
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse
Mayo Clinic Cancer Center, Rochester
Rapid City Regional Hospital, Rapid City
Trinity Cancer Care Center, Minot
Northwest Community Hospital, Arlington Heights
Alexian Brothers Cancer Care Center, Elk Grove Village
Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey
Cancer Care Center at Advocate Good Samaritan Hospital, Downers Grove
Mount Sinai Hospital Medical Center, Chicago
Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago
Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago
Saint Louis University Cancer Center, St Louis
Siteman Cancer Center at Barnes-Jewish Hospital, St Louis
Cancer Institute of Cape Girardeau, Cape Girardeau
CCOP - Kansas City, Kansas City
Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia
CCOP - Cancer Research for the Ozarks, Springfield
St. John's Regional Health Center, Springfield
Hulston Cancer Center at Cox Medical Center South, Springfield
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha, Omaha
Cancer Center at Medical Center of Louisiana - New Orleans, New Orleans
MBCCOP - LSU Health Sciences Center, New Orleans
Tulane Cancer Center, New Orleans
New Orleans Cancer Institute at Memorial Medical Center, New Orleans
Baton Rouge General Regional Cancer Center, Baton Rouge
Mary Bird Perkins Cancer Center - Baton Rouge, Baton Rouge
LaFortune Cancer Center at St. John Health System, Tulsa
Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa
M.D. Anderson Cancer Center at University of Texas, Houston
Brooke Army Medical Center, Fort Sam Houston
Wilford Hall Medical Center, Lackland Air Force Base
Harrington Cancer Center, Amarillo
Memorial Hospital Cancer Center, Colorado Springs
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center, Boise
Utah Cancer Specialists at UCS Cancer Center, Salt Lake City
Cottonwood Hospital Medical Center, Murray
Huntsman Cancer Institute at University of Utah, Salt Lake City
LDS Hospital, Salt Lake City
McKay-Dee Hospital Center, Ogden
Utah Valley Regional Medical Center - Provo, Provo
Dixie Regional Medical Center, St. George
Foundation for Cancer Research and Education, Phoenix
CCOP - Mayo Clinic Scottsdale Oncology Program, Scottsdale
Scottsdale Healthcare - Shea, Scottsdale
Virginia G. Piper Cancer Center at Scottsdale Healthcare - Osborn, Scottsdale
University Medical Center of Southern Nevada, Las Vegas
CCOP - Southern Nevada Cancer Research Foundation, Las Vegas
Washoe Cancer Services at Washoe Medical Center - Reno, Reno
Cancer Care Consultants Medical Associates at Daniel Freeman Memorial Hospital, Inglewood
Providence Saint Joseph Medical Center - Burbank, Burbank
Pomona Valley Hospital Medical Center, Pomona
Naval Medical Center - San Diego, San Diego
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda
Saint Rose Hospital, Hayward
Valley Memorial Hospital, Livermore
Highland General Hospital, Oakland
CCOP - Bay Area Tumor Institute, Oakland
Summit Medical Center, Oakland
J.C. Robinson, M.D. Regional Cancer Center, San Pablo
Radiological Associates of Sacramento Medical Group, Inc., Sacramento
University of California Davis Cancer Center, Sacramento
North Star Lodge Cancer Center, Yakima
Washington Hematology - Oncology Specialists, Yakima
USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles
Providence Holy Cross Cancer Center, Mission Hills
University of Colorado Cancer Center at University of Colorado Health Sciences Center, Denver
Massachusetts General Hospital Cancer Center, Boston
Cancer Research Center at Boston Medical Center, Boston
Hudner Oncology Center at Saint Anne's Hospital, Fall River
Cape Cod Hospital, Hyannis
South Suburban Oncology Center, Quincy
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital, Ann Arbor
Barbara Ann Karmanos Cancer Institute, Detroit
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon
Cancer Institute of New Jersey at the Cooper University Hospital, Camden
Monmouth Medical Center, Long Branch
South Jersey Healthcare Regional Cancer Center, Millville
Fox Chase Virtua Health Cancer Program - Marlton, Mount Holly
Community Medical Center, Toms River
Aultman Hospital Cancer Center at Aultman Health Foundation, Canton
Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey
Fox Chase Cancer Center, Philadelphia
Fletcher Allen Health Care - University Health Center Campus, Burlington
Naval Medical Center - Portsmouth, Portsmouth
Massey Cancer Center at Virginia Commonwealth University, Richmond
Community Memorial Health Center, South Hill
Green Bay Oncology, Limited at St. Vincent Hospital, Green Bay
Oconomowoc Memorial Hospital, Oconomowoc
Collaborators (1)
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER
Radiation Therapy Oncology Group
NETWORK