A Study of Abciximab and Reteplase When Administered Prior to Catherization After a Myocardial Infarction (Finesse)

PHASE3CompletedINTERVENTIONAL
Enrollment

2,461

Participants

Timeline

Start Date

August 31, 2002

Primary Completion Date

January 31, 2008

Study Completion Date

January 31, 2008

Conditions
Myocardial Infarction
Interventions
DRUG

abciximab placebo; reteplase placebo, abciximab, abciximab

placebo bolus; 1-2 placebo bolus; 0.25 mg/kg bolus; 0.125 ¼g/kg/min, max 10 ¼g/min infusion x 12h

DRUG

Abciximab; reteplase; abciximab placebo; abciximab

0.25 mg/kg bolus; 1-2, 5 unit boluses; placebo bolus; 0.125 ¼g/kg/min, max 10 ¼g/min infusion x 12h

DRUG

abciximab; reteplase placebo; abciximab placebo; abciximab

0.25 mg/kg bolus; 1-2 placebo boluses; placebo bolus; 0.125 ¼g/kg/min, max 10 ¼g/min infusion x 12h

DRUG

abciximab placebo; reteplase placebo, abciximab, abciximab

placebo bolus; 1-2 placebo bolus; 0.25 mg/kg bolus; 0.125 ¿g/kg/min, max 10 ¿g/min infusion x 12h

DRUG

abciximab; reteplase placebo; abciximab placebo; abciximab

0.25 mg/kg bolus; 1-2 placebo boluses; placebo bolus; 0.125 ¿g/kg/min, max 10 ¿g/min infusion x 12h

DRUG

Abciximab; reteplase; abciximab placebo; abciximab

0.25 mg/kg bolus; 1-2, 5 unit boluses; placebo bolus; 0.125 ¿g/kg/min, max 10 ¿g/min infusion x 12h

Trial Locations (227)

Unknown

Phoenix

Covina

Modesto

Newark

Washington D.C.

Clearwater

Jacksonville

Miami

St. Petersburg

Tallahassee

Weston

Harvey

Rock Island

Lexington

Louisville

New Orleans

Lewiston

Worcester

Ann Arbor

Pontiac

St Louis

Brooklyn

Flushing

Mineola

New York

Raleigh

Winston-Salem

Akron

Cleveland

Dayton

Westlake

Oklahoma City

Tulsa

Hershey

Philadelphia

Sayre

Sellersville

Upland

Wormleysburg

York

Pawtucket

Providence

Spartanburg

Bristol

Kingsport

Amarillo

Galveston

Houston

Lubbock

Bremerton

Marshfield

Waukesha

Adrogué

Buenos Aires

Corrientes

Merlo

Rosario

San Martín

Bruck an der Mur

Deutschlandsberg

Innsbruck

Linz

Vienna

Antwerp

Bonheiden

Eeklo

Ghent

Herentals

Mechelen

Reet

Turnhout

Waregem

Westmalle

Dimitrovgrad

Haskovo

Plovdiv

Sofia

Edmonton

Montreal

Repentigny

Benesov U Prahy

Bílovec

Boskovice

Brno

Bruntál

Čáslav

České Budějovice

Český Krumlov

Havíøov 1

Hodonín

Hradec Králové

Hranice

Jeseník

Jičín

Jihlava

Karniva-Ray N/A

Kyjov

Most

Nový Jičín

Odry

Olomouc

Ostrava

Písek

Poruba

Prague

Praha 10 N/A

Prostějov

Přerov

Strakonice

Svitavy

Šumperk

Tábor

Teplice

Trutnov

Tøebíè 1

Tøinec 1

Ústí nad Labem

Ústí nad Orlicí

Valašské Meziříčí

Vyškov

Znojmo

Esbjerg

Frederikshavn

Hjÿrring N/A

Horsens

Kÿbenhavn Nv N/A

Kÿbenhavn Sud N/A

Kÿbenhavn Ÿ

Odense

Randers

Silkeborg

Viborg

Ÿlborg

Ÿrhus N

Besançon

Colmar

Metz

Nancy

Nancy Cedex N/A

Nîmes

Paris

Vandœuvre-lès-Nancy

Aachen

Bad Nauheim

Bad Segeberg

Bremen

Dresden

Eschweiler

Friedberg

Fulda

Hamburg

Kaltenkirchen

Magdeburg

Mannheim

Meißen

München

Münster

Pfaffenhofen

Radebeul

Schönebeck

Jerusalem

Ramat Gan

Leeuwarden

Będzin

Bielsko-Biala

Bolesławiec

Brzeg

Częstochowa

Gdansk

Gdynia Poland

Gliwice

Gmina Końskie

Gorlice

Grójec

Jastrzębie Zdrój

Katowice

Konin

Kościerzyna

Krakow

Lodz

Nowy Dwor M

Nysa

Opole

Piotrkow Trybunalski

Poznan

Radomsko

Ruda Śląska

Skierniewice

Swidnica

Tychy

Ustroń

Warsaw

Warszawa Poland

Wroclaw

Zabrze

Żyrardów

Bucharest

Cluj-Napoca

Iași

Târgu Mureş

Arcadia Pretoria N/A

Cape Town Western Province

Roodepoort Central Gauteng

Alicante

Barcelona

Madrid

Santander

Santiago de Compostela

Gothenburg

Basel

Bruderholz

Liestal

Antrim

Belfast

Brighton

Chichester

Durham

Glasgow

London

Manchester

Middlesbrough

Plymouth

Portadown

Saint Leonards-on-Sea

Southampton

Stockton-on-Tees

Worthing

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

lead

Centocor, Inc.

INDUSTRY