Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer

PHASE3UnknownINTERVENTIONAL
Enrollment

348

Participants

Timeline

Start Date

December 31, 2006

Primary Completion Date

November 30, 2022

Conditions
Glioblastoma MultiformeGlioblastomaGBMGrade IV AstrocytomaGliomaBrain CancerBrain Tumor
Interventions
DRUG

Dendritic cell immunotherapy

Two intradermal (i.d.) injections of DCVax-L(treatment cohort) or autologous PBMC (placebo cohort) per treatment. Treatments will be given at days 0, 10, 20, and at weeks 8, 16, 32, 48, 72, 96 and 120.

Trial Locations (86)

10016

New York University Clinical Cancer Center, New York

10032

Columbia University Medical Center, New York

10604

Brain and Spine Surgeons of New York and Northern Westchester Hospital, White Plains

11030

North Shore University Hospital, Manhasset

11042

Long Island Brain Tumor Center at Neurological Surgery, P.C., Lake Success

11794

Stony Brook Medicine, Stony Brook

14642

University of Rochester Medical Center, Rochester

17822

Geisinger Medical Center, Danville

19104

Hospital of the University of Pennsylvania, Philadelphia

19107

Jefferson Hospital for Neuroscience, Philadelphia

19140

Temple University School of Medicine, Philadelphia

20057

Georgetown University Medical Center, Washington D.C.

20246

Neurochirurgische Klinik, Hamburg

23215

Aurora Saint Luke's Medical Center, Milwaukee

27157

Wake Forest Baptist Medical Center, Winston-Salem

27514

University of North Carolina, Chapel Hill, Chapel Hill

29425

Medical University of South Carolina Hospitals and Clinics, Charleston

30309

Piedmont Atlanta Hospital, Atlanta

32611

University of Florida, Gainesville

33021

Memorial Cancer Institute, Hollywood

33140

Mount Sinai Community Clinical Oncology Program, Miami Beach

33612

Moffitt Cancer Center, Tampa

35294

University of Alabama at Birmingham, Birmingham

37205

Saint Thomas Research Institute, Nashville

37232

Vanderbilt Ingram Cancer Center, Nashville

40202

Norton Cancer Institute, Louisville

40536

Markey Cancer Center/University of Kentucky, Lexington

43210

Ohio State University, Columbus

43214

OhioHealth, Columbus

44106

University Hospitals Seidman Cancer Center, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

45267

University of Cincinnati Cancer Institute, Cincinnati

46202

IU Simon Cancer Center, Indianapolis

48109

University of Michigan Cancer Center, Ann Arbor

48202

Henry Ford Hospital, Detroit

49503

Spectrum Health, Grand Rapids

50924

Universitätsklinikum Klinik für allgemeine Neurochirurgie, Cologne

53105

Universitätsklinikum Bonn Nervenklinik (Zentrum), Klinik und Poliklinik für Neurochirurgie, Bonn

55407

John Nasseff Neuroscience Institute at Abbott Northwestern Hospital, Minneapolis

60528

Universitätsklinikum FrankfurtKlinik und Poliklinik für Neurochirurgie, Frankfurt am Main

60555

Cadence Cancer Center, Warrenville

60612

Rush University Medical Center, Chicago

61615

Illinois Cancer Care, Peoria

63110

Washington University School of Medicine, St Louis

64111

St. Luke's Hospital, Kansas City

66205

University of Kansas Cancer Center, Westwood

69120

Universitätsklinikum Heidelberg Neurochirurgische Klinik, Heidelberg

70174

Katharinenhospital, Stuttgart

72205

University of Arkansas for Medical Sciences, Little Rock

73104

Oklahoma University Health Science Center, Oklahoma City

75246

Baylor Research Institute, Dallas

77030

The Methodist Hospital, Houston

University of Texas Health Science Center at Houston, Houston

78229

Cancer Therapy & Research at University of Texas Health Science Center San Antonio, San Antonio

80045

University of Colorado Cancer Center, Aurora

80113

Colorado Neurological Institute, Englewood

90027

Kaiser Permanente - Los Angeles, Los Angeles

90095

UCLA Medical Center, Los Angeles

91010

City of Hope, Duarte

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

92868

St. Joseph Hospital of Orange, Orange

University of California, Irvine Medical Center, Orange

93093

UCSD Moores Cancer Center, La Jolla

94063

Kaiser Permanente - Redwood City, Redwood City

94546

Sutter East Bay Neuroscience Institute-Eden Medical Center, Castro Valley

95816

Sutter Institute for Medical Research, Sacramento

98101

Benaroya Research Institute at Virginia Mason, Seattle

98122

Swedish Hospital Neuroscience Research, Seattle

02111

Tufts Medical Center, Boston

02215

Beth Israel Deaconess Medical Center, Boston

08818

The Brain Tumor Center at JFK Medical Center, Edison

07601

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

07450

The Valley Hospital, Ridgewood

07902

Overlook Hospital, Summit

08638

Capital Health Regional Medical Center, Trenton

10029-6574

Mount Sinai Medical Center, New York

02903

Rhode Island Hospital, Providence

H3A 2B4

Montreal Neurological Institute, McGill University, Montreal

J1H 5N4

CHUS - Hôpital Fleurimont, Sherbrooke

09116

Klinik für Neurochirurgie, Klinikum Chemnitz gGmbH, Chemnitz

01307

Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden

06112

BG-Kliniken Bergmannstrost, Klinik für Neurochirurgie, Halle

CB2 2QQ

Addenbrookes NHS Trust, Cambridge

SE5 9RS

Kings College Hosital NHS Foundation Trust, London

WC1E 6BT

University College Hospital London, London

N15 2WB

University Hospital of Birmingham NHS Foundation Trust, Birmingham

Sponsors
All Listed Sponsors
lead

Northwest Biotherapeutics

INDUSTRY

NCT00045968 - Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer | Biotech Hunter | Biotech Hunter