Randomized Trial Of Exemestane Versus Continued Tamoxifen In Postmenopausal Women With Early Breast Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

4,740

Participants

Timeline

Start Date

February 28, 1998

Primary Completion Date

June 30, 2003

Study Completion Date

March 31, 2013

Conditions
Breast Neoplasms
Interventions
DRUG

Tamoxifen

Tamoxifen 20 mg/day tablets administered p.o. for a period ranging from 2.5 to 3 years.

DRUG

Exemestane

Exemestane 25 mg/day tablets administered p.o. for a period ranging from 2.5 to 3 years.

Trial Locations (377)

1000

Pfizer Investigational Site, Brussels

Pfizer Investigational Site, Ljubljana

1082

Pfizer Investigational Site, Budapest

1122

Pfizer Investigational Site, Budapest

1142

Pfizer Investigational Site, Auckland

1145

Pfizer Investigational Site, Budapest

1180

Pfizer Investigational Site, Brussels

1181

Pfizer Investigational Site, Buenos Aires

1210

Pfizer Investigational Site, Luxembourg

1406

Pfizer Investigational Site, Buenos Aires

1417

Pfizer Investigational Site, Buenos Aires

1425

Pfizer Investigational Site, Buenos Aires

1426

Pfizer Investigational Site, Buenos Aires

1504

Pfizer Investigational Site, Sofia

1603

Pfizer Investigational Site, Fredrikstad

1642

Pfizer Investigational Site, San Isidro

1650

Pfizer Investigational Site, San Martín

1706

Pfizer Investigational Site, Haedo

1756

Pfizer Investigational Site, Sofia

1784

Pfizer Investigational Site, Sofia

1950

Pfizer Investigational Site, Kraainem

2000

Pfizer Investigational Site, Rosario

2020

Pfizer Investigational Site, Antwerp

2021

Pfizer Investigational Site, Hamilton

2050

Pfizer Investigational Site, Camperdown

2100

Pfizer Investigational Site, Koebenhavn OE

2170

Pfizer Investigational Site, Liverpool

Pfizer Investigational Site, Merksem

2196

Pfizer Investigational Site, Johannesburg

2298

Pfizer Investigational Site, Waratah

2610

Pfizer Investigational Site, Wilrijk

2650

Pfizer Investigational Site, Edegem

2730

Pfizer Investigational Site, Herlev

2830

Pfizer Investigational Site, Dubbo

2930

Pfizer Investigational Site, Brasschaat

3000

Pfizer Investigational Site, Leuven

3010

Pfizer Investigational Site, Bern

3040

Pfizer Investigational Site, Coimbra

3103

Pfizer Investigational Site, Tønsberg

3128

Pfizer Investigational Site, Box Hill

3135

Pfizer Investigational Site, Ringwood East

3400

Pfizer Investigational Site, Hilleroed

3500

Pfizer Investigational Site, Hasselt

3552

Pfizer Investigational Site, Bendigo

3600

Pfizer Investigational Site, Genk

3660

Pfizer Investigational Site, Rjukan

3674

Pfizer Investigational Site, Notodden

4000

Pfizer Investigational Site, Liège

Pfizer Investigational Site, Roskilde

4004

Pfizer Investigational Site, Plovdiv

4700

Pfizer Investigational Site, Næstved

4800

Pfizer Investigational Site, Verviers

5000

Pfizer Investigational Site, Adelaide

Pfizer Investigational Site, Namur

5021

Pfizer Investigational Site, Bergen

5390

Pfizer Investigational Site, Haugesund

6000

Pfizer Investigational Site, Charleroi

6003

Pfizer Investigational Site, Stara Zagora

6407

Pfizer Investigational Site, Molde

6700

Pfizer Investigational Site, Arlon

Pfizer Investigational Site, Esbjerg

7100

Pfizer Investigational Site, Haine-Saint-Paul

Pfizer Investigational Site, La Louvière

Pfizer Investigational Site, Vejle

Pfizer Investigational Site, Rissa

7331

Pfizer Investigational Site, Baudour

7400

Pfizer Investigational Site, Herning

7600

Pfizer Investigational Site, Levanger

7925

Pfizer Investigational Site, Observatory

8000

Pfizer Investigational Site, Aarhus C

8092

Pfizer Investigational Site, Bodø

8607

Pfizer Investigational Site, Mo i Rana

8800

Pfizer Investigational Site, Viborg

9038

Pfizer Investigational Site, Tromsø

10000

Pfizer Investigational Site, Zagreb

10117

Pfizer Investigational Site, Berlin

10126

Pfizer Investigational Site, Torino

11000

Pfizer Investigational Site, Belgrade

12051

Pfizer Investigational Site, Alba (CN)

12100

Pfizer Investigational Site, Cuneo

12206

Pfizer Investigational Site, Albany

12808

Pfizer Investigational Site, Prague

13273

Pfizer Investigational Site, Marseille

13353

Pfizer Investigational Site, Berlin

13900

Pfizer Investigational Site, Biella

14004

Pfizer Investigational Site, Córdoba

14076

Pfizer Investigational Site, Caen

15033

Pfizer Investigational Site, Casale Monferrato, AL

15057

Pfizer Investigational Site, Tortona

16128

Pfizer Investigational Site, Genova

16132

Pfizer Investigational Site, Genova

17027

Pfizer Investigational Site, Pietra Ligure (SV)

19002

Pfizer Investigational Site, Guadalajara

20014

Pfizer Investigational Site, Donostia / San Sebastian

20052

Pfizer Investigational Site, Monza

20075

Pfizer Investigational Site, Lodi

20121

Pfizer Investigational Site, Milan

20133

Pfizer Investigational Site, Milan

20141

Pfizer Investigational Site, Milan

21053

Pfizer Investigational Site, Milan

21100

Pfizer Investigational Site, Varese

21204

Pfizer Investigational Site, Kamenitz

22081

Pfizer Investigational Site, Hamburg

22300

Pfizer Investigational Site, Barbastro

23538

Pfizer Investigational Site, Lübeck

23900

Pfizer Investigational Site, Lecco

24047

Pfizer Investigational Site, Treviglio (BG)

24069

Pfizer Investigational Site, Trescore Balneario BG

24128

Pfizer Investigational Site, Bergamo

25198

Pfizer Investigational Site, Lleida

26100

Pfizer Investigational Site, Cremona

27000

Pfizer Investigational Site, Évreux

28034

Pfizer Investigational Site, Madrid

28040

Pfizer Investigational Site, Madrid

28041

Pfizer Investigational Site, Madrid

29100

Pfizer Investigational Site, Piacenza

31502

Pfizer Investigational Site, Toulouse

32073

Pfizer Investigational Site, Orange Park

32204

Pfizer Investigational Site, Jacksonville

32207

Pfizer Investigational Site, Jacksonville

32250

Pfizer Investigational Site, Jacksonville Beach

33081

Pfizer Investigational Site, Aviano (PN)

34362

Pfizer Investigational Site, Haifa

34474

Pfizer Investigational Site, Ocala

35042

Pfizer Investigational Site, Rennes

35205

Pfizer Investigational Site, Birmingham

35213

Pfizer Investigational Site, Birmingham

35235

Pfizer Investigational Site, Birmingham

36016

Pfizer Investigational Site, Thiene (VI)

41012

Pfizer Investigational Site, Carpi

41100

Pfizer Investigational Site, Modena

42015

Pfizer Investigational Site, Correggio

42100

Pfizer Investigational Site, Reggio Emilia

43100

Pfizer Investigational Site, Parma

43201

Pfizer Investigational Site, Reus

44805

Pfizer Investigational Site, Saint-Herblain

46014

Pfizer Investigational Site, Valencia

46037

Pfizer Investigational Site, Fishers

46038

Pfizer Investigational Site, Fishers

46100

Pfizer Investigational Site, Mantova

46219

Pfizer Investigational Site, Indianapolis

46227

Pfizer Investigational Site, Indianapolis

50009

Pfizer Investigational Site, Zaragoza

50134

Pfizer Investigational Site, Florence

50182

Pfizer Investigational Site, Borås

51014

Pfizer Investigational Site, Tartu

52403

Pfizer Investigational Site, Cedar Rapids

56100

Pfizer Investigational Site, Pisa

59381

Pfizer Investigational Site, Västervik

63011

Pfizer Investigational Site, Clermont-Ferrand

63023

Pfizer Investigational Site, Fermo FM

66046

Pfizer Investigational Site, Perpignan

66113

Pfizer Investigational Site, Saarbrücken

69373

Pfizer Investigational Site, Lyon

71000

Pfizer Investigational Site, Sarajevo

72000

Pfizer Investigational Site, Le Mans

72435

Pfizer Investigational Site, Bucharest

74011

Pfizer Investigational Site, Annecy

75042

Pfizer Investigational Site, Garland

75090

Pfizer Investigational Site, Sherman

75150

Pfizer Investigational Site, Mesquite

75231

Pfizer Investigational Site, Dallas

75246

Pfizer Investigational Site, Dallas

75601

Pfizer Investigational Site, Longview

75702

Pfizer Investigational Site, Tyler

76022

Pfizer Investigational Site, Bedford

76600

Pfizer Investigational Site, Le Havre

77024

Pfizer Investigational Site, Houston

77029

Pfizer Investigational Site, Houston

77030

Pfizer Investigational Site, Houston

77074

Pfizer Investigational Site, Houston

77100

Pfizer Investigational Site, Meaux

77479

Pfizer Investigational Site, Sugar Land

77502

Pfizer Investigational Site, Pasadena

78217

Pfizer Investigational Site, San Antonio

78503

Pfizer Investigational Site, McAllen

78596

Pfizer Investigational Site, Weslaco

79106

Pfizer Investigational Site, Freiburg im Breisgau

79761

Pfizer Investigational Site, Odessa

79902

Pfizer Investigational Site, El Paso

79915

Pfizer Investigational Site, El Paso

80131

Pfizer Investigational Site, Napoli

80218

Pfizer Investigational Site, Denver

80228

Pfizer Investigational Site, Lakewood

80260

Pfizer Investigational Site, Thornton

80304

Pfizer Investigational Site, Boulder

80335

Pfizer Investigational Site, München

80528

Pfizer Investigational Site, Fort Collins

80909

Pfizer Investigational Site, Colorado Springs

84082

Pfizer Investigational Site, Avignon

85614

Pfizer Investigational Site, Green Valley

Pfizer Investigational Site, Green Velley

85704

Pfizer Investigational Site, Tucson

85710

Pfizer Investigational Site, Tucson

85712

Pfizer Investigational Site, Tucson

85715

Pfizer Investigational Site, Tucson

85745

Pfizer Investigational Site, Tucson

90139

Pfizer Investigational Site, Palermo

91054

Pfizer Investigational Site, Erlangen

91120

Pfizer Investigational Site, Jerusalem

92210

Pfizer Investigational Site, Saint-Cloud

92637

Pfizer Investigational Site, Weiden

97225

Pfizer Investigational Site, Portland

97227

Pfizer Investigational Site, Portland

97517

Pfizer Investigational Site, Banská Bystrica

98527

Pfizer Investigational Site, Suhl

98646

Pfizer Investigational Site, Hildburghausen

99202

Pfizer Investigational Site, Spokane

99218

Pfizer Investigational Site, Spokane

197758

Pfizer Investigational Site, Saint Petersburg

300223

Pfizer Investigational Site, Timișoara

400015

Pfizer Investigational Site, Cluj-Napoca

IN 46219

Pfizer Investigational Site, Indianapolis

01201

Pfizer Investigational Site, Pittsfield

12110-0610

Pfizer Investigational Site, Latham

76014-2084

Pfizer Investigational Site, Arlington

75230-2510

Pfizer Investigational Site, Dallas

75075-7787

Pfizer Investigational Site, Plano

Unknown

Pfizer Investigational Site, Buenos Aires

Pfizer Investigational Site, Rosario

Pfizer Investigational Site, Osijek

Pfizer Investigational Site, Split

Pfizer Investigational Site, Zagreb

Pfizer Investigational Site, Cairo

Pfizer Investigational Site, New Territories

Pfizer Investigational Site, Cork

Pfizer Investigational Site, Cork, Ireland

Pfizer Investigational Site, Dublin

Pfizer Investigational Site, Galway

Pfizer Investigational Site, Haifa

Pfizer Investigational Site, Jerusalem

Pfizer Investigational Site, Kfar Saba

Pfizer Investigational Site, Petah Tikva

Pfizer Investigational Site, Rehovot

Pfizer Investigational Site, Oslo

Pfizer Investigational Site, Sandefjord

Pfizer Investigational Site, Coimbra

Pfizer Investigational Site, Lincoln

Pfizer Investigational Site, Shrewsbury

X5000AA1

Pfizer Investigational Site, Córdoba

656 53

Pfizer Investigational Site, Brno

370 87

Pfizer Investigational Site, České Budějovice

33030 Cedex

Pfizer Investigational Site, Bordeaux

33300 Cedex

Pfizer Investigational Site, Bordeaux

49033 Cedex 01

Pfizer Investigational Site, Angers

29609 Cedex

Pfizer Investigational Site, Brest

14052 Cedex

Pfizer Investigational Site, Caen

77405 Cedex

Pfizer Investigational Site, Lagny-sur-Marne

59020 Cedex

Pfizer Investigational Site, Lille

25209 Cedex

Pfizer Investigational Site, Montbéliard

68070 Cedex

Pfizer Investigational Site, Mulhouse

06189

Pfizer Investigational Site, Nice

75248 Cedex 5

Pfizer Investigational Site, Paris

75970 Cedex 20

Pfizer Investigational Site, Paris

76038 Cedex

Pfizer Investigational Site, Rouen

67091 Cedex

Pfizer Investigational Site, Strasbourg

09126

Pfizer Investigational Site, Chemnitz

07548

Pfizer Investigational Site, Gera

07973

Pfizer Investigational Site, Greiz

06110

Pfizer Investigational Site, Halle

06120

Pfizer Investigational Site, Halle

04129

Pfizer Investigational Site, Leipzig

01589

Pfizer Investigational Site, Riesa

08228

Pfizer Investigational Site, Rodewisch

115 22

Pfizer Investigational Site, Athens

115 28

Pfizer Investigational Site, Athens

71 110

Pfizer Investigational Site, Heraklion

09121

Pfizer Investigational Site, Cagliari

09042

Pfizer Investigational Site, Monserrato (CA)

06132

Pfizer Investigational Site, Perugia

00148

Pfizer Investigational Site, Roma

07100

Pfizer Investigational Site, Sassari

05100

Pfizer Investigational Site, Terni

VLT 14

Pfizer Investigational Site, Floriana

3818 ES

Pfizer Investigational Site, Amersfoort

1061 AE

Pfizer Investigational Site, Amsterdam

1066 CX

Pfizer Investigational Site, Amsterdam

1105 AZ

Pfizer Investigational Site, Amsterdam

7300 DS

Pfizer Investigational Site, Apeldoorn

1261 AN

Pfizer Investigational Site, Blaricum

4818 CK

Pfizer Investigational Site, Breda

2625 AD

Pfizer Investigational Site, Delft

5623 EJ

Pfizer Investigational Site, Eindhoven

7513 ER

Pfizer Investigational Site, Enschede

9700 RM

Pfizer Investigational Site, Groningen

9728 NZ

Pfizer Investigational Site, Groningen

7555 DL

Pfizer Investigational Site, Hengelo

8934 AD

Pfizer Investigational Site, Leeuwarden

2333 ZA

Pfizer Investigational Site, Leiden

2262 BA

Pfizer Investigational Site, Leidschendam

5200 ME Den Bosch

Pfizer Investigational Site, Podybus 90153

6043 CV

Pfizer Investigational Site, Roermond

6131 BK

Pfizer Investigational Site, Sittard

2545 CH

Pfizer Investigational Site, The Hague

3582 KE

Pfizer Investigational Site, Utrecht

5504 DB

Pfizer Investigational Site, Veldhoven

1502 DV

Pfizer Investigational Site, Zaandam

L34

Pfizer Investigational Site, Lima

80-952

Pfizer Investigational Site, Gdansk

44-101

Pfizer Investigational Site, Gliwice

31-115

Pfizer Investigational Site, Krakow

31-826

Pfizer Investigational Site, Krakow

93-509

Pfizer Investigational Site, Lodz

45-060

Pfizer Investigational Site, Opole

61-878

Pfizer Investigational Site, Poznan

81-756

Pfizer Investigational Site, Sopot

02-781

Pfizer Investigational Site, Warsaw

7000-811

Pfizer Investigational Site, Evora

SK-83310

Pfizer Investigational Site, Bratislava

041 90

Pfizer Investigational Site, Košice

02006

Pfizer Investigational Site, Albacete

03804

Pfizer Investigational Site, Alcoy

03010

Pfizer Investigational Site, Alicante

03203

Pfizer Investigational Site, Elche

03550

Pfizer Investigational Site, Sant Joan d'Alacant

06008

Pfizer Investigational Site, Badajoz

06080

Pfizer Investigational Site, Badajoz

08911

Pfizer Investigational Site, Badalona

08916

Pfizer Investigational Site, Badalona

08221

Pfizer Investigational Site, Terrassa

08227

Pfizer Investigational Site, Terrassa

501 82

Pfizer Investigational Site, Borås

413 45

Pfizer Investigational Site, Gothenburg

301 85

Pfizer Investigational Site, Halmstad

251 87

Pfizer Investigational Site, Helsingborg

291 85

Pfizer Investigational Site, Kristianstad

581 85

Pfizer Investigational Site, Linköping

221 85

Pfizer Investigational Site, Lund

205 02

Pfizer Investigational Site, Malmo

591 85

Pfizer Investigational Site, Motala

575 81

Pfizer Investigational Site, Nässjö

601 82

Pfizer Investigational Site, Norrköping

351 85

Pfizer Investigational Site, Vaxjo

331 85

Pfizer Investigational Site, Värnamo

721 89

Pfizer Investigational Site, Västerås

CH-4031

Pfizer Investigational Site, Basel

CH-6500

Pfizer Investigational Site, Bellinzona

CH-3012

Pfizer Investigational Site, Bern

CH-1211

Pfizer Investigational Site, Geneva

PE18 8NT

Pfizer Investigational Site, Huntingdon

BH7 7DW

Pfizer Investigational Site, Bournemouth

HU16 5JQ

Pfizer Investigational Site, Hull

CM166TN

Pfizer Investigational Site, Epping

SS0 0RY

Pfizer Investigational Site, Westcliff-on-Sea

NP6 2UB

Pfizer Investigational Site, Newport

LL57 2PW

Pfizer Investigational Site, Bangor

HX6 0PW

Pfizer Investigational Site, Salterhebble

PO12 2AA

Pfizer Investigational Site, Gosport

HA6 2RN

Pfizer Investigational Site, Northwood

HG2 7SX

Pfizer Investigational Site, Harrogate

BT47 1SB

Pfizer Investigational Site, Londonderry

TA1 5DA

Pfizer Investigational Site, Taunton

SA2 8QA

Pfizer Investigational Site, Swansea

Y03 7He

Pfizer Investigational Site, York

BT97AB

Pfizer Investigational Site, Belfast

BD9 6RJ

Pfizer Investigational Site, Bradford

BS10 5NB

Pfizer Investigational Site, Bristol

CF14 2TL

Pfizer Investigational Site, Cardiff

CV2 2DX

Pfizer Investigational Site, Coventry

G75 8RG

Pfizer Investigational Site, East Kilbride

HD3 3EA

Pfizer Investigational Site, Huddersfield

LS1 3EX

Pfizer Investigational Site, Leeds

LS9 7TF

Pfizer Investigational Site, Leeds

N18 1QX

Pfizer Investigational Site, London

N19 5NF

Pfizer Investigational Site, London

NW3 2QG

Pfizer Investigational Site, London

SW17 0QT

Pfizer Investigational Site, London

W6 8RF

Pfizer Investigational Site, London

LU4 0DZ

Pfizer Investigational Site, Luton

M20 4BX

Pfizer Investigational Site, Manchester

S10 2SJ

Pfizer Investigational Site, Sheffield

BA21 4AT

Pfizer Investigational Site, Somerset

S016 6YD

Pfizer Investigational Site, Southampton

BD20 6TD

Pfizer Investigational Site, Steeton

ST4 6QG

Pfizer Investigational Site, Stoke-on-Trent

TF1 6TF

Pfizer Investigational Site, Telford

M23 9LT

Pfizer Investigational Site, Wythenshawe, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

International Collaborative Cancer Group

OTHER

lead

Pfizer

INDUSTRY