1,791
Participants
Start Date
December 1, 2000
Primary Completion Date
May 30, 2008
Study Completion Date
May 30, 2008
Insulin
Insulin (intermediate or long-lasting) in a.m. 1 unit 9 lbs Arm 1 Insulin (intermediate or long-lasting) in a.m. 1 unit 9 lbs, add one injection of insulin Arm 2
Glimepiride
Glimepiride 2 mg Arm 1 Glimepiride 8 mg Arm 2
Rosiglitazone
Rosiglitazone 4 mg Arm 1 Rosiglitazone 4 mg bid Arm 2
Metformin
Metformin 500 mg (go up to 1000 mg) Arm 1 Metformin 500 mg (go up to 2000 mg) Arm
VA Pittsburgh Health Care System, Pittsburgh
Hunter Holmes McGuire VA Medical Center, Richmond
VA Medical Center, Salem VA, Salem
Miami VA Healthcare System, Miami, FL, Miami
VA Medical Center, Lexington, Lexington
VA Medical Center, Minneapolis, Minneapolis
Michael E. DeBakey VA Medical Center (152), Houston
VA South Texas Health Care System, San Antonio, San Antonio
Carl T. Hayden VA Medical Center, Phoenix
Southern Arizona VA Health Care System, Tucson, Tucson
VA Medical Center, Long Beach, Long Beach
VA San Diego Healthcare System, San Diego, San Diego
VA Central California Health Care System, Fresno, Fresno
VA Puget Sound Health Care System, Seattle, Seattle
Edward Hines, Jr. VA Hospital, Hines
Richard Roudebush VA Medical Center, Indianapolis, Indianapolis
VA Medical Center, Omaha, Omaha
VA New Jersey Health Care System, East Orange, East Orange
Ralph H Johnson VA Medical Center, Charleston, Charleston
VA Medical Center, Nashville
VA Medical Center, San Juan, San Juan
Collaborators (1)
National Eye Institute (NEI)
NIH
SmithKline Beecham
INDUSTRY
VA Office of Research and Development
FED