1,449
Participants
Start Date
October 18, 2001
Primary Completion Date
January 12, 2012
Study Completion Date
March 19, 2026
Aldesleukin
Given IV
Dinutuximab
Given IV
Isotretinoin
Given PO
Laboratory Biomarker Analysis
Correlative studies
Pharmacological Study
Correlative studies
Quality-of-Life Assessment
Ancillary studies
Sargramostim
Given IV or SC
Starship Children's Hospital, Grafton
Sydney Children's Hospital, Randwick
The Children's Hospital at Westmead, Westmead
John Hunter Children's Hospital, Hunter Regional Mail Centre
Royal Children's Hospital, Parkville
Royal Brisbane and Women's Hospital, Herston
Royal Children's Hospital-Brisbane, Herston
Queensland Children's Hospital, South Brisbane
Women's and Children's Hospital-Adelaide, North Adelaide
Princess Margaret Hospital for Children, Perth
Christchurch Hospital, Christchurch
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Mount Sinai Hospital, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Montefiore Medical Center - Moses Campus, The Bronx
New York Medical College, Valhalla
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
NYU Langone Hospital - Long Island, Mineola
Albany Medical Center, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
University of Rochester, Rochester
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Penn State Children's Hospital, Hershey
Geisinger Medical Center, Danville
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Children's Hospital of Philadelphia, Philadelphia
Saint Christopher's Hospital for Children, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
MedStar Georgetown University Hospital, Washington D.C.
Children's National Medical Center, Washington D.C.
University of Maryland/Greenebaum Cancer Center, Baltimore
Sinai Hospital of Baltimore, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Inova Fairfax Hospital, Falls Church
University of Virginia Cancer Center, Charlottesville
VCU Massey Comprehensive Cancer Center, Richmond
Children's Hospital of The King's Daughters, Norfolk
Carilion Children's, Roanoke
West Virginia University Healthcare, Morgantown
Wake Forest University Health Sciences, Winston-Salem
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke University Medical Center, Durham
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Novant Health Presbyterian Medical Center, Charlotte
Mission Hospital, Asheville
Prisma Health Richland Hospital, Columbia
Medical University of South Carolina, Charleston
BI-LO Charities Children's Cancer Center, Greenville
Greenville Cancer Treatment Center, Greenville
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
Augusta University Medical Center, Augusta
Memorial Health University Medical Center, Savannah
Nemours Children's Clinic-Jacksonville, Jacksonville
Nemours Children's Clinic - Pensacola, Pensacola
University of Florida Health Science Center - Gainesville, Gainesville
AdventHealth Orlando, Orlando
Arnold Palmer Hospital for Children, Orlando
Nemours Children's Clinic - Orlando, Orlando
Orlando Health Cancer Institute, Orlando
Nemours Children's Hospital, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Nicklaus Children's Hospital, Miami
Miami Cancer Institute, Miami
Broward Health Medical Center, Fort Lauderdale
Saint Mary's Medical Center, West Palm Beach
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Lee Memorial Health System, Fort Myers
Golisano Children's Hospital of Southwest Florida, Fort Myers
Children's Hospital of Alabama, Birmingham
University of Alabama at Birmingham Cancer Center, Birmingham
Vanderbilt University/Ingram Cancer Center, Nashville
T C Thompson Children's Hospital, Chattanooga
East Tennessee Childrens Hospital, Knoxville
Saint Jude Children's Research Hospital, Memphis
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
University of Kentucky/Markey Cancer Center, Lexington
Nationwide Children's Hospital, Columbus
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Mercy Children's Hospital, Toledo
Rainbow Babies and Childrens Hospital, Cleveland
Cleveland Clinic Foundation, Cleveland
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Dayton Children's Hospital, Dayton
Riley Hospital for Children, Indianapolis
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
C S Mott Children's Hospital, Ann Arbor
Wayne State University/Karmanos Cancer Institute, Detroit
Henry Ford Health Saint John Hospital, Detroit
Hurley Medical Center, Flint
Michigan State University, East Lansing
Bronson Methodist Hospital, Kalamazoo
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
Blank Children's Hospital, Des Moines
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Children's Hospital of Wisconsin, Milwaukee
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
Marshfield Medical Center-Marshfield, Marshfield
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
University of Minnesota/Masonic Cancer Center, Minneapolis
Mayo Clinic in Rochester, Rochester
Sanford Broadway Medical Center, Fargo
Advocate Children's Hospital-Oak Lawn, Oak Lawn
Lurie Children's Hospital-Chicago, Chicago
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Saint Jude Midwest Affiliate, Peoria
Southern Illinois University School of Medicine, Springfield
Cardinal Glennon Children's Medical Center, St Louis
Washington University School of Medicine, St Louis
Mercy Hospital Saint Louis, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
University of Missouri Children's Hospital, Columbia
Children's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
Children's Hospital New Orleans, New Orleans
University of Arkansas for Medical Sciences, Little Rock
University of Oklahoma Health Sciences Center, Oklahoma City
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
Methodist Children's Hospital of South Texas, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Dell Children's Medical Center of Central Texas, Austin
Children's Hospital Colorado, Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
Primary Children's Hospital, Salt Lake City
Phoenix Childrens Hospital, Phoenix
Banner University Medical Center - Tucson, Tucson
University of New Mexico Cancer Center, Albuquerque
Nevada Cancer Research Foundation NCORP, Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Children's Hospital Los Angeles, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Miller Children's and Women's Hospital Long Beach, Long Beach
City of Hope Comprehensive Cancer Center, Duarte
Rady Children's Hospital - San Diego, San Diego
Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
Valley Children's Hospital, Madera
UCSF Medical Center-Parnassus, San Francisco
UCSF Medical Center-Mission Bay, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
UCSF Benioff Children's Hospital Oakland, Oakland
Kaiser Permanente-Oakland, Oakland
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
University of Hawaii Cancer Center, Honolulu
Kapiolani Medical Center for Women and Children, Honolulu
Tripler Army Medical Center, Honolulu
Legacy Emanuel Children's Hospital, Portland
Legacy Emanuel Hospital and Health Center, Portland
Oregon Health and Science University, Portland
Seattle Children's Hospital, Seattle
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Providence Alaska Medical Center, Anchorage
Arkansas Children's Hospital, Little Rock
Connecticut Children's Medical Center, Hartford
Yale University, New Haven
Maine Children's Cancer Program, Scarborough
Walter Reed National Military Medical Center, Bethesda
Tufts Children's Hospital, Boston
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber Cancer Institute, Boston
Baystate Medical Center, Springfield
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Hackensack University Medical Center, Hackensack
Morristown Medical Center, Morristown
Saint Peter's University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Newark Beth Israel Medical Center, Newark
Overlook Hospital, Summit
Rhode Island Hospital, Providence
Sanford USD Medical Center - Sioux Falls, Sioux Falls
University of Vermont and State Agricultural College, Burlington
Naval Medical Center - Portsmouth, Portsmouth
Alberta Children's Hospital, Calgary
University of Alberta Hospital, Edmonton
British Columbia Children's Hospital, Vancouver
CancerCare Manitoba, Winnipeg
Janeway Child Health Centre, St. John's
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Children's Hospital, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
The Montreal Children's Hospital of the MUHC, Montreal
Centre Hospitalier Universitaire Sainte-Justine, Montreal
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec
San Jorge Children's Hospital, San Juan
National Cancer Institute (NCI)
NIH