Comparison of Combination Chemotherapy Regimens in Treating Older Women Who Have Undergone Surgery for Breast Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

633

Participants

Timeline

Start Date

September 30, 2001

Primary Completion Date

May 31, 2008

Study Completion Date

November 30, 2012

Conditions
Breast Cancer
Interventions
DRUG

Standard Treatment

Cyclophosphamide 100 mg/sq m PO d 1-14 + MTX 40 mg/sq m IV push d 1 \& 8 and 5-FU 600 mg/sq m IV push d 1 \& 8 q 28 days for 6 cycles OR doxorubicin 60 mg/sq m IV d 1 + cyclophosphamide 600 mg/sq m IV d 1 q 21 d for 4 cycles

DRUG

capecitabine

2000 mg/sq m PO d 1-14, 7 day rest then repeat for a total of 6 cycles

Trial Locations (334)

10021

Memorial Sloan-Kettering Cancer Center, New York

10456

Bronx-Lebanon Hospital Center & BronxCare Adult Medical Practice, The Bronx

11501

Winthrop University Hospital, Mineola

12801

Adirondack Cancer Care - Glens Falls, Glens Falls

Charles R. Wood Cancer Center at Glens Falls Hospital, Glens Falls

13057

CCOP - Hematology-Oncology Associates of Central New York, Syracuse

13210

SUNY Upstate Medical University Hospital, Syracuse

14620

Highland Hospital of Rochester, Rochester

14642

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester

16335

Meadville Medical Center, Meadville

16801

Geisinger Medical Group - Scenery Park, State College

16803

Mount Nittany Medical Center, State College

17044

Lewistown Hospital, Lewistown

18015

St. Luke's Hospital Cancer Center, Bethlehem

18301

Dale and Frances Hughes Cancer Center at Pocono Medical Center, East Stroudsburg

18510

Hematology and Oncology Associates, Scranton

18711

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre

19010

Bryn Mawr Hospital, Bryn Mawr

19013

Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center, Upland

19096

CCOP - MainLine Health, Wynnewood

Lankenau Cancer Center at Lankenau Hospital, Wynnewood

19604

St. Joseph Medical Center, Reading

19713

CCOP - Christiana Care Health Services, Newark

19901

Kent General Hospital at Bayhealth Medical Center, Dover

20016

Sibley Memorial Hospital, Washington D.C.

21201

Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore

21701

Frederick Memorial Hospital Regional Cancer Therapy Center, Frederick

22901

Martha Jefferson Hospital Cancer Care Center, Charlottesville

25701

Marshall University Medical Center, Huntington

27320

Annie Penn Cancer Center, Reidsville

27534

Wayne Memorial Hospital, Incorporated, Goldsboro

27710

Duke Comprehensive Cancer Center, Durham

28053

CaroMont Cancer Center at Gaston Memorial Hospital, Gastonia

28139

Rutherford Hospital, Rutherfordton

28374

FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center, Pinehurst

28401

Zimmer Cancer Center at New Hanover Regional Medical Center, Wilmington

28801

Mission Hospitals - Memorial Campus, Asheville

29303

CCOP - Upstate Carolina, Spartanburg

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg

29425

Hollings Cancer Center at Medical University of South Carolina, Charleston

29621

AnMed Health Cancer Center, Anderson

30045

Gwinnett Medical Center, Lawrenceville

30342

CCOP - Atlanta Regional, Atlanta

30901

Augusta Oncology Associates - Walton Way, Augusta

31405

Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler, Savannah

32115

Halifax Medical Center - Daytona Beach, Daytona Beach

32224

Mayo Clinic - Jacksonville, Jacksonville

33136

University of Miami Sylvester Comprehensive Cancer Center, Miami

33140

CCOP - Mount Sinai Medical Center, Miami Beach

33308

Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital, Fort Lauderdale

33401

Palm Beach Cancer Institute - West Palm Beach, West Palm Beach

33458

Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter

33805

Lakeland Regional Cancer Center at Lakeland Regional Medical Center, Lakeland

35294

University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham

37203

Nashville Oncology Associates, P.C., Nashville

37604

East Tennessee State University Cancer Center at Johnson City Medical Center, Johnson City

37916

Thompson Cancer Survival Center, Knoxville

39581

Regional Cancer Center at Singing River Hospital, Pascagoula

43402

Wood County Oncology Center, Bowling Green

43420

Fremont Memorial Hospital, Fremont

43537

Northwest Ohio Oncology Center, Maumee

St. Luke's Hospital, Maumee

43560

Flower Hospital Cancer Center, Sylvania

43567

Fulton County Health Center, Wauseon

43606

Toledo Hospital, Toledo

43608

St. Vincent Mercy Medical Center, Toledo

43614

Medical University of Ohio Cancer Center, Toledo

43616

St. Charles Mercy Hospital, Oregon

Toledo Clinic - Oregon, Oregon

43617

CCOP - Toledo Community Hospital, Toledo

43623

Toledo Clinic, Incorporated - Main Clinic, Toledo

44106

Case Comprehensive Cancer Center, Cleveland

44109

MetroHealth's Cancer Care Center at MetroHealth Medical Center, Cleveland

44870

Firelands Regional Medical Center, Sandusky

North Coast Cancer Care, Incorporated, Sandusky

45044

Middletown Regional Hospital, Middletown

45267

Charles M. Barrett Cancer Center at University Hospital, Cincinnati

45385

Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital, Dayton

45409

David L. Rike Cancer Center at Miami Valley Hospital, Dayton

45415

Samaritan North Cancer Care Center, Dayton

45428

Veterans Affairs Medical Center - Dayton, Dayton

45429

Charles F. Kettering Memorial Hospital, Kettering

45801

St. Rita's Medical Center, Lima

45804

Lima Memorial Hospital, Lima

46107

St. Francis Hospital and Health Centers - Beech Grove Campus, Beech Grove

46321

Community Hospital, Munster

46360

Saint Anthony Memorial Health Centers, Michigan City

46601

CCOP - Northern Indiana CR Consortium, South Bend

46815

Fort Wayne Medical Oncology and Hematology, Fort Wayne

47403

Regional Cancer Institute at Bloomington Hospital, Bloomington

48073

William Beaumont Hospital - Royal Oak Campus, Royal Oak

48075

Providence Cancer Institute at Providence Hospital - Southfield Campus, Southfield

48144

Haematology-Oncology Associates of Ohio and Michigan, PC, Lambertville

48162

Community Cancer Center of Monroe, Monroe

Mercy Memorial Hospital System, Monroe

48202

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit

49085

Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph, Saint Joseph

49221

Hickman Cancer Center at Bixby Medical Center, Adrian

49503

CCOP - Grand Rapids, Grand Rapids

49770

Northern Michigan Hospital, Petoskey

50010

McFarland Clinic, PC, Ames

50702

Cedar Valley Medical Specialists, PC - West Ridgeway Avenue, Waterloo

51503

Heartland Oncology & Hematology, Council Bluffs

52402

St. Luke's Hospital, Cedar Rapids

52403

Cedar Rapids Oncology Associates, Cedar Rapids

Mercy Regional Cancer Center at Mercy Medical Center, Cedar Rapids

52501

McCreery Cancer Center at Ottumwa Regional, Ottumwa

52722

Hematology Oncology Associates of the Quad Cities, Bettendorf

52803

Genesis Regional Cancer Center at Genesis Medical Center, Davenport

53121

Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn, Elkhorn

53215

Medical Consultants, Limited, Milwaukee

53717

Dean Medical Center - Madison, Madison

54311

Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center, Green Bay

54401

University of Wisconcin Cancer Center at Aspirus Wausau Hospital, Wausau

54601

Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse

55101

Regions Hospital Cancer Care Center, Saint Paul

55102

St. Joseph's Hospital, Saint Paul

United Hospital, Saint Paul

55109

HealthEast Cancer Care at St. John's Hospital, Maplewood

Minnesota Oncology Hematology, PA at Maplewood Cancer Center, Maplewood

55125

Minnesota Oncology Hematology, PA - Woodbury, Woodbury

Woodwinds Health Campus, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55355

Meeker County Memorial Hospital, Lichfield

55379

Saint Francis Cancer Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Virginia Piper Cancer Institute at Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center - Minneapolis, Minneapolis

55416

CCOP - Metro-Minnesota, Saint Louis Park

Park Nicollet Health Services, Saint Louis Park

55432

Mercy and Unity Cancer Center at Unity Hospital, Fridley

55433

Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55455

University of Minnesota Medical Center & Children's Hospital - Fairview, Minneapolis

55805

Cancer Care Center at St. Luke's Hospital, Duluth

CCOP - Duluth, Duluth

55905

Mayo Clinic Cancer Center, Rochester

56002

Immanuel St. Joseph's Clinic, Mankato

56007

Albert Lea Cancer Center at Albert Lea Medical Center, Albert Lea

56201

Willmar Cancer Center at Rice Memorial Hospital, Willmar

56265

Chippewa County - Montevideo Hospital, Montevideo

56303

CentraCare Clinic - River Campus, Saint Cloud

56601

MeritCare Clinic - Bemidji, Bemidji

57105

Avera Cancer Institute, Sioux Falls

Medical X-Ray Center, PC, Sioux Falls

57401

Oncology Services of Aberdeen, Aberdeen

58122

CCOP - MeritCare Hospital, Fargo

MeritCare Medical Group, Fargo

58201

Altru Cancer Center at Altru Hospital, Grand Forks

58501

Cancer Care Center at Medcenter One Hospital, Bismarck

Mid Dakota Clinic, PC, Bismarck

58701

Trinity Cancer Care Center, Minot

59101

CCOP - Montana Cancer Consortium, Billings

59405

Great Falls Clinic, Great Falls

Sletten Regional Cancer Institute at Benefis Healthcare, Great Falls

60048

North Shore Oncology and Hematology Associates, Limited - Libertyville, Libertyville

60076

Hematology Oncology Associates - Skokie, Skokie

Hematology/Oncology of the North Shore at Gross Point Medical Center, Skokie

60202

St. Francis Hospital, Evanston

60432

Midwest Center for Hematology/Oncology, Joliet

60435

Joliet Oncology-Hematology Associates, Limited - West, Joliet

60461

Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields, Olympia Fields

60507

Rush-Copley Cancer Care Center, Aurora

60611

Hematology and Oncology Associates, Chicago

60612

Veterans Affairs Medical Center - Chicago Westside Hospital, Chicago

60616

Mercy Hospital and Medical Center, Chicago

60625

Swedish Covenant Hospital, Chicago

60714

Cancer Care and Hematology Specialists of Chicagoland - Niles, Niles

60901

Provena St. Mary's Wasser Regional Cancer Center - Kankakee, Kankakee

61108

Center for Cancer Care at OSF Saint Anthony Medical Center, Rockford

61350

Community Hospital of Ottawa, Ottawa

61354

Illinois Valley Community Hospital, Peru

61356

Perry Memorial Hospital, Princeton

61362

St. Margaret's Hospital, Spring Valley

61401

Galesburg Clinic, Galesburg

Galesburg Cottage Hospital, Galesburg

61455

McDonough District Hospital, Macomb

61520

Graham Hospital, Canton

61530

Eureka Community Hospital, Eureka

61554

Cancer Treatment Center at Pekin Hospital, Pekin

61614

Proctor Hospital, Peoria

61615

CCOP - Illinois Oncology Research Association, Peoria

Oncology Hematology Associates of Central Illinois, PC - Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF St. Francis Medical Center, Peoria

61701

St. Joseph Medical Center, Bloomington

61747

Hopedale Medical Complex, Hopedale

61761

BroMenn Regional Medical Center, Normal

Community Cancer Center, Normal

61801

Carle Cancer Center at Carle Foundation Hospital, Urbana

CCOP - Carle Cancer Center, Urbana

62321

Memorial Hospital, Carthage

62526

Decatur Memorial Hospital Cancer Care Institute, Decatur

62644

Mason District Hospital, Havana

63110

Siteman Cancer Center at Barnes-Jewish Hospital, St Louis

63131

Missouri Baptist Cancer Center, St Louis

65203

Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia

65804

St. John's Regional Health Center, Springfield

65807

Hulston Cancer Center at Cox Medical Center South, Springfield

66604

Stormont-Vail Cancer Center, Topeka

66606

St. Francis Comprehensive Cancer Center, Topeka

68106

CCOP - Missouri Valley Cancer Consortium, Omaha

68122

Immanuel Medical Center, Omaha

68124

Alegant Health Cancer Center at Bergan Mercy Medical Center, Omaha

68803

Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center, Grand Island

70112

MBCCOP - LSU Health Sciences Center, New Orleans

71101

Christus Schumpert Cancer Treatment Center, Shreveport

71913

St. Joseph's Mercy Cancer Center, Hot Springs

73104

Oklahoma University Medical Center, Oklahoma City

73120

Cancer Care Associates - Mercy Campus, Oklahoma City

73505

Cleo Craig Cancer Research Clinic, Lawton

74104

LaFortune Cancer Center at St. John Medical Center, Tulsa

78234

Brooke Army Medical Center, Fort Sam Houston

78236

Wilford Hall Medical Center, Lackland Air Force Base

80909

Memorial Hospital, Colorado Springs

83404

Hematology Oncology Associates of Eastern Idaho, Idaho Falls

84112

Huntsman Cancer Institute at University of Utah, Salt Lake City

89102

University Medical Center of Southern Nevada, Las Vegas

89106

CCOP - Nevada Cancer Research Foundation, Las Vegas

89703

Carson-Tahoe Cancer Services at Carson Tahoe Regional Healthcare, Carson City

91204

Glendale Memorial Hospital Comprehensive Cancer Center, Glendale

91328

Leavey Cancer Center at Northridge Hospital Medical Center, Northridge

92120

Kaiser Permanente Medical Office -Vandever Medical Office, San Diego

93901

Salinas Valley Memorial Hospital, Salinas

94545

Saint Rose Hospital, Hayward

94588

Valley Care Medical Center, Pleasanton

94602

Highland General Hospital at St. George's University School of Medicine, Oakland

94609

Alta Bates Summit Medical Center - Summit Campus, Oakland

CCOP - Bay Area Tumor Institute, Oakland

94806

Doctors Medical Center - San Pablo Campus, San Pablo

96701

Kapiolani Medical Center at Pali Momi, ‘Aiea

96793

Pacific Cancer Institute - Maui, Wailuku, Maui

96813

Cancer Research Center of Hawaii, Honolula

OnCare Hawaii, Incorporated - Lusitana, Honolulu

Queen's Cancer Institute at Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Incorporated, Honolulu

96817

OnCare Hawaii, Incorporated - Kuakini, Honolulu

St. Francis Medical Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

98002

Auburn Regional Center for Cancer Care, Auburn

98003

St. Francis Hospital, Federal Way

98112

Group Health Central Hospital, Seattle

98225

St. Joseph Cancer Center, Bellingham

98372

Good Samaritan Cancer Center, Puyallup

98405

CCOP - Northwest, Tacoma

98431

Madigan Army Medical Center - Tacoma, Tacoma

98499

St. Clare Hospital, Tacoma

98507

Capital Medical Center, Olympia

98902

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

99202

Cancer Care Northwest - Spokane South, Spokane

99204

Providence Cancer Center at Sacred Heart Medical Center, Spokane

99207

Providence Cancer Center at Holy Family Hospital, Spokane

36652-2144

Mobile Infirmary Medical Center, Mobile

85259-5499

Mayo Clinic Scottsdale, Scottsdale

85724-5024

Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson

92093-0658

Moores UCSD Cancer Center, La Jolla

90089-9181

USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles

06360

Eastern Connecticut Hematology and Oncology Associates, Norwich

20307-5001

Walter Reed Army Medical Center, Washington D.C.

60611-3013

Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago

60612-7243

University of Illinois Cancer Center, Chicago

60637-1470

University of Chicago Cancer Research Center, Chicago

60201-1781

Evanston Northwestern Healthcare - Evanston Hospital, Evanston

61104-2315

Swedish-American Regional Cancer Center, Rockford

62781-0001

Regional Cancer Center at Memorial Medical Center, Springfield

04240

Central Maine Medical Center, Lewiston

04101

Mercy Hospital of Portland, Portland

04074

Maine Center for Cancer Medicine and Blood Disorders - Scarborough, Scarborough

04901

MaineGeneral Medical Center - Waterville Campus, Waterville

21231-2410

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

02111

Tufts-NEMC Cancer Center, Boston

02115

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston

02118

Cancer Research Center at Boston Medical Center, Boston

02130

Faulkner Hospital, Boston

01742

Bethke Cancer Center at Emerson Hospital, Concord

02601

Cape Cod Hospital, Hyannis

01852

Saints Memorial Cancer Center at Saints Memorial Medical Center, Lowell

02155

Lawrence Memorial Hospital of Medford, Medford

02062

Caritas Norwood Hospital, Norwood

02190

South Shore Hospital, South Weymouth

49007-3731

West Michigan Cancer Center, Kalamazoo

55422-2900

Hubert H. Humphrey Cancer Center at North Memorial Medical Center, Robbinsdale

68848-1990

Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney

68131-2197

Creighton University Medical Center, Omaha

68198-6805

UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha

03038

Parkland Oncology-Hematology Clinic at Parkland Medical Center, Derry

03106

New Hampshire Oncology-Hematology, PA - Hooksett, Hooksett

03246

Lakes Region General Hospital, Laconia

03103

Elliot Regional Cancer Center at Elliot Hospital, Manchester

08724

Ocean Medical Center at Meridian Health, Brick

08053

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton

07962

Carol G. Simon Cancer Center at Morristown Memorial Hospital, Morristown

07701

Booker Cancer Center at Riverview Medical Center, Red Bank

07902

Overlook Hospital, Summit

08755

J. Phillip Citta Regional Cancer Center at Community Medical Center, Toms River

08043

Fox Chase Virtua Health Cancer Program at Virtua West Jersey, Voorhees Township

14263-0001

Roswell Park Cancer Institute, Buffalo

11794-8174

Stony Brook University Cancer Center, Stony Brook

27203-5400

Randolph Hospital, Asheboro

27403-1198

Moses Cone Regional Cancer Center at Wesley Long Community Hospital, Greensboro

44309-2090

Akron City Hospital, Akron

44710-1799

Aultman Hospital Cancer Center at Aultman Health Foundation, Canton

45373-1300

UVMC Cancer Care Center at Upper Valley Medical Center, Troy

17822-0001

Geisinger Medical Center, Danville

17033-0850

Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey

19301-1792

Cancer Center of Paoli Memorial Hospital, Paoli

19107-5541

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia

15224-1791

Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital, Pittsburgh

19612-6052

Reading Hospital and Medical Center, Reading

19390-9499

Jennersville Regional Hospital, West Grove

02860

Memorial Hospital of Rhode Island, Pawtucket

02886

Kent County Memorial Hospital, Warwick

57117-5039

Sioux Valley Hospital and University of South Dakota Medical Center, Sioux Falls

37208-3599

MBCCOP - Meharry Medical College - Nashville, Nashville

05602

Mountainview Medical, Berlin Corners

05401

Fletcher Allen Health Care - University Health Center Campus, Burlington

98506-5166

Providence St. Peter Hospital Regional Cancer Center, Olympia

98122-4307

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle

98195-6043

University Cancer Center at University of Washington Medical Center, Seattle

98405-3004

St. Joseph Medical Center at Franciscan Health System, Tacoma

53792-6164

University of Wisconsin Comprehensive Cancer Center, Madison

54221-1450

Holy Family Memorial Medical Center Cancer Care Center, Manitowoc

53201-0342

Aurora Sinai Medical Center, Milwaukee

T2N 4N2

Tom Baker Cancer Centre - Calgary, Calgary

T6G 1Z2

Cross Cancer Institute at University of Alberta, Edmonton

R3E 0V9

CancerCare Manitoba, Winnipeg

M5G 1X5

Mount Sinai Hospital - Toronto, Toronto

N8W 2X3

Windsor Regional Cancer Centre at Windsor Regional Hospital, Windsor

C1A 8T5

Prince Edward Island Cancer Centre at Queen Elizabeth Hospital, Charlottetown

S4T 7T1

Allan Blair Cancer Centre at Pasqua Hospital, Regina

Lima 34

Instituto Nacional de Enfermedades Neoplasicas, Lima

Sponsors
All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

NCIC Clinical Trials Group

NETWORK

lead

Alliance for Clinical Trials in Oncology

OTHER