Warfarin and Antiplatelet Therapy in Chronic Heart Failure

PHASE3CompletedINTERVENTIONAL
Enrollment

1,587

Participants

Timeline

Start Date

October 31, 1998

Primary Completion Date

July 31, 2003

Study Completion Date

December 31, 2004

Conditions
Heart Failure
Interventions
DRUG

Warfarin titrated to an INR of 2.5-3.0

anticoagulation (administered without blinding) titrated to a target INR of 2.5 to 3.0, monitored by measurements at 6 week intervals after initial titration and stabilization.

DRUG

Aspirin

an antiplatelet agent whose mechanism is inhibition of thromboxane, a platelet activator) administered in a double blind manner.

DRUG

Clopidogrel 75

(an antiplatelet agent whose mechanism is ADP inhibition) administered in a double blind manner)

Trial Locations (134)

10010

New York Harbor HCS, New York

11030

North Shore University Hospital, Manhasset

11355

New York Hospital Medical Center Of Queens, Flushing

11768

VA Medical Center, Northport, Northport

12208

VA Stratton Medical Center, Albany, Albany

13210

VA Medical Center, Syracuse, Syracuse

14215

VA Western New York Healthcare System at Buffalo, Buffalo

14642

University of Rochester Medical Center, Rochester

15240

VA Pittsburgh Health Care System, Pittsburgh

19104

VA Medical Center, Philadelphia, Philadelphia

20422

VA Medical Center, DC, Washington D.C.

23249

Hunter Holmes McGuire VA Medical Center, Richmond

24592

DUCCS Research of South Boston, South Boston

25041

VA Medical Center, Martinsburg, Martinsburg

25704

VA Medical Center, Huntington, Huntington

27705

VA Medical Center, Durham, Durham

28739

Margaret Pardee Memorial Hospital, Hendersonville

30033

Atlanta VA Medical and Rehab Center, Decatur, Decatur

30904

VA Medical Center, Augusta, Augusta

32501

Cardiology Consultants - Pensacola, Pensacola

32608

North Florida/South Georgia Veterans Health System, Gainesville

32952

Brevard Cardiology, Merritt Island

33125

VA Medical Center, Miami, Miami

33321

University Cardiology Consultants, Tamarac

33462

Florida Cardiovascular Research, Atlantis

33612

James A. Haley Veterans Hospital, Tampa, Tampa

33708

VA Medical Center, Bay Pines, Bay Pines

33805

Watson Clinic LLP, Lakeland

35233

VA Medical Center, Birmingham, Birmingham

38104

VA Medical Center, Memphis, Memphis

39531

VA Gulf Coast Veterans Health Care System, Biloxi, Biloxi

44106

VA Medical Center, Cleveland, Cleveland

45220

VA Medical Center, Cincinnati, Cincinnati

45428

VA Medical Center, Dayton, Dayton

47130

River Cities Cardiology, Jeffersonville

48095

William Beaumont Hospital, Trey

48113

VA Ann Arbor Healthcare System, Ann Arbor

48201

John D. Dingell VA Medical Center, Detroit, Detroit

53705

Wlliam S. Middleton Memorial Veterans Hospital, Madison, Madison

55417

VA Medical Center, Minneapolis, Minneapolis

57741

VA Black Hills Health Care System, Fort Meade, Fort Meade

58102

VA Medical Center, Fargo, Fargo

60612

Jesse Brown VAMC (WestSide Division), Chicago

61603

Heart Care Midwest, Peoria

63106

VA Medical Center, St Louis, St Louis

64128

VA Medical Center, Kansas City MO, Kansas City

68510

Lincoln Division VA Nebraska Western IA HCS, Lincoln

71101

Overton Brooks VA Medical Center, Shreveport, Shreveport

73104

VA Medical Center, Oklahoma City, Oklahoma City

74401

VA Medical Center, Muskogee, Muskogee

77030

Michael E. DeBakey VA Medical Center (152), Houston

78229

VA South Texas Health Care System, San Antonio, San Antonio

80220

VA Eastern Colorado Health Care System, Denver, Denver

84148

VA Salt Lake City Health Care System, Salt Lake City, Salt Lake City

85012

Carl T. Hayden VA Medical Center, Phoenix

85723

Southern Arizona VA Health Care System, Tucson, Tucson

89502

VA Sierra Nevada Health Care System, Reno

90073

VA Greater Los Angeles Healthcare System, West LA, West Los Angeles

90242

Rancho Los Amigos National Rehabilitation Center, Downey

91343

VA Greater Los Angeles HCS, Sepulveda, Sepulveda

92357

VA Medical Center, Loma Linda, Loma Linda

93703

VA Central California Health Care System, Fresno, Fresno

94121

VA Medical Center, San Francisco, San Francisco

94598

Cardiovascular Consultants, Walnut Creek, Walnut Creek

97201

VA Medical Center, Portland, Portland

72114-1706

Central Arkansas VHS Eugene J. Towbin Healthcare Ctr, Little Rock, No. Little Rock

94304-1290

VA Palo Alto Health Care System, Palo Alto

06418

Cardiology Associates of Derby, P.C., Derby

06120

St. Francis Hospital and Medical Center, Hartford

06516

VA Connecticut Health Care System (West Haven), West Haven

60141-5000

Edward Hines, Jr. VA Hospital, Hines

01730

Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Bedford

02301

VA Boston Healthcare System, Brockton Campus, Brockton

01104

Bay State Medical Center, Springfield

27599-7075

Univ of North Carolina at Chapel Hill, Chapel Hill

43203-1278

Chalmers P. Wylie VAOPC, Columbus

02908

VA Medical Center, Providence, Providence

37212-2637

VA Medical Center, Nashville

77555-0553

University of Texas Medical Branch, Galveston

T2E 7C5

Cardiology Consultants, Calgary

T6G 2B7

University of Alberta Hospital, Edmonton

T6L 5X8

Grey Nuns Com. Hospital and Health Centre, Edmonton

V9W 6X8

Alder Medical Centre, Campbell River

V7L 2P7

North Shore Cardiology Laboratory, North Vancouver

V3V 1Z2

Surrey Memorial Hospital - Cardiology, Surrey

R2H 2A6

St. Boniface General Hospital, Winnipeg

R3A 1R9

Health Sciences Centre - Cardiology Research, Winnipeg

B3H 3A7

Queen Elizabeth II HSC, Halifax

L1S 7K8

Ajax and Pickering General Hospital, Ajax

L6V 1B4

Bramptom, Research Associates, Brampton

P3E 6B4

Neureka Research Inc. Willett Green Millr Cntr, Greater Sudbury

L8L 2X2

Hamilton Health Sciences Corp. - General Div, Hamilton

L8P 3B6

St. Joseph's Hospital, Hamilton

N6A 5A5

London HSC - University Campus, London

L5M 2N1

Credit Valley Hospital Research Associates, Mississauga

L2E 7H1

Niagara Falls Medical Center, Niagara Falls

K1Y 4W7

Ottawa Heart Institute, Ottawa

M9V 4B8

Etobicoke General Hospital, Rexdale

M1S 4V5

Cardiology Research Associates, Scarborough Village

M5B 1W8

St. Michael's Hospital, Toronto

M5T 2S8

Toronto Western Hospital, Toronto

J4N 1E1

Invascor Clinical Research Inc., Longeuil

H1T 2M4

Cardiology Clinic - Maisonneuve-Rosemont, Montreal

G6P 6N2

Hotel-Dieu D'Artabaska, Victoriaville

S4P 0W5

Regina General Hospital, Regina

S7K 0Z9

St. Paul's Hospital, Saskatoon

S7N 0W8

Royal University Hospital, Saskatoon

BT12 6BA

Royal Victoria Hospital, Belfast

LU4 0DZ

Luton and Dunstable Hospital, Luton

B29 6JD

Selly Oak Hospital, Selly Oak

YO16 4QP

Bridlington and District Hospital, Bridlington

SK2 7JE

Stepping Hills Hospital, Stockport

TS4 3BW

South Cleveland Hospital, Middlesbrough

DE1 2QY

Derbyshire Royal Infirmary, Derby

PL6 8DH

Derriford Hospital, Devon

TQ2 7AA

Torbay District General, Torbay

IG3 8YB

King Geroge Hospital, Ilford

G12 8QQ

Glasgow Western Infirmary, Glasgow

HU16 5JG

Castle Hill Hospital, Cottingham

FY3 8NR

Blackpool Victoria Hospital, Blackpool

SE1 7EH

St. Thomas' Hospital, London

E13 8SL

Newham General Hospital, Plaistow

M23 9LT

Wythenshawe Hospital, Wythenshawe

HA1 3UJ

Northwick Park Hospital and Institue for Medical R, Harrow

DN15 7BH

Scunthorpe General Hospital, Scunthorpe

YO3 7HE

York District Hospital, York

PA2 9PN

Royal Alexandra Hospital, Paisley

DN33 2BA

Princess of Wales Hospital (Grimsby), Grimsby

S75 2EP

Barnsley District General, Barnsley

BN2 1ES

Cardiology Research Unit Sussex House, Brighton

WF1 4DG

Pinderfields General Hospital, Wakefield

LS9 7TF

St. James' University Hospital, Leeds

WF8 1PL

Pontefract General Infirmary, Pontefract

S5 7AU

Northern General Hospital, Sheffield

Sponsors
All Listed Sponsors
collaborator

Sanofi-Synthelabo

INDUSTRY

collaborator

Bristol-Myers Squibb

INDUSTRY

lead

US Department of Veterans Affairs

FED