23
Participants
Start Date
November 30, 1999
Primary Completion Date
March 31, 2002
Study Completion Date
November 30, 2005
90-Y-ibritumomab tiuxetan
IDEC-Y2B8 is a mouse monoclonal antibody with small particles of radioactivity that join to the CD20 antigens on lymphoma cells. It is used to deliver radiation therapy to kill lymphoma cells. This is a one time intravenous infusion for eligible patients and is given over a ten-minute time period.
rituximab
Rituxan is a mouse/human monoclonal antibody and reacts with the CD20 antigens found on lymphoma cells and causes the body's immune system to destroy the lymphoma cells. It is infused at a dose of 250 mg/m2 followed by a second infusion approximately one week later of the same dose.
indium In 111 ibritumomab tiuxetan
IDEC-In2B8 is a mouse monoclonal antibody that contains Indium, routinely used in nuclear medicine. It is given as a one-time intravenous injection over a ten-minute time period immediately following a Rituxan infusion. The physician will then be able to see and evaluate the location and concentration of the antibody in the body.
Lombardi Cancer Center, Washington D.C.
University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham
Collaborators (1)
National Cancer Institute (NCI)
NIH
Biogen
INDUSTRY
University of Alabama at Birmingham
OTHER