230
Participants
Start Date
June 30, 2000
Primary Completion Date
February 1, 2015
Study Completion Date
May 14, 2018
BCNU 80mg/m2
BCNU 80 mg/m2 will be administered as an intravenous infusion on days 1, 2, and 3 of the first week of radiotherapy and on days 56, 57, and 58, then every eight weeks for four more cycles for a total of 6 cycles (maximum BCNU dose 1440 mg/m2).
TMZ 200mg/m2
200 mg/m2 orally on days 1-5 of the first week of radiotherapy. Repeat every 28 days for a total of 12 cycles.
radiation therapy
1.8 Gy fractions (to isocenter), 1 fraction per day, 5 days per week to a dose of 59.4 Gy in 33 fractions.
CCNU
CCNU at 130 mg/m2 orally every 8 weeks for a total of 6 cycles. Administered on day 1 of the first week of radiotherapy and on day 56, then administered every 8 weeks for four more cycles for a total of 6 cycles.
BCNU 150mg/m2
BCNU 150 mg/m2 will be administered as an intravenous infusion on day 5 of radiotherapy, and it will be repeated every eight weeks for a total of six cycles (maximum total BCNU dose 900 mg/m2).
BCNU 200mg/m2
BCNU 200 mg/m2 will be administered as an intravenous infusion on day 1 of radiotherapy and will be repeated every six weeks for a total of 6 cycles (maximum BCNU dose 1200 mg/m2).
TMZ 150mg/m2 six 6-week cycles
150 mg/m2 orally on days 1-5 of the first week of radiotherapy. Repeat for a total of six 6-week cycles
TMZ 150mg/m2 six 8-week cycles
150 mg/m2 orally on days 1-5 of the first week of radiotherapy. Repeat for a total of six 8-week cycles
Lipson Cancer and Blood Center at Rochester General Hospital, Rochester
Allegheny Cancer Center at Allegheny General Hospital, Pittsburgh
Guthrie Cancer Center at Guthrie Clinic Sayre, Sayre
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore
Mission Hospitals - Memorial Campus, Asheville
John B. Amos Cancer Center, Columbus
Florida Oncology Associates, Orange Park
Flagler Cancer Center, Saint Augustine
Florida Cancer Center - Palatka, Palatka
Baptist Cancer Institute - Jacksonville, Jacksonville
Florida Oncology Associates at Southside Cancer Center, Jacksonville
Integrated Community Oncology Network, Jacksonville Beach
Baptist Medical Center South, Jacksonville
Lynn Regional Cancer Center at Boca Raton Community Hospital - Main Center, Boca Raton
Case Comprehensive Cancer Center, Cleveland
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford, Salem
Cancer Treatment Center, Wooster
Charles M. Barrett Cancer Center at University Hospital, Cincinnati
McFarland Clinic, PC, Ames
Community Memorial Hospital Cancer Care Center, Menomonee Falls
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette
University of Wisconcin Cancer Center at Aspirus Wausau Hospital, Wausau
Theda Care Cancer Institute, Appleton
CCOP - Duluth, Duluth
Rapid City Regional Hospital, Rapid City
CCOP - Montana Cancer Consortium, Billings
Community Hospital of Ottawa, Ottawa
Oncology Hematology Associates of Central Illinois, PC - Ottawa, Ottawa
Illinois Valley Community Hospital, Peru
Perry Memorial Hospital, Princeton
St. Margaret's Hospital, Spring Valley
Valley Cancer Center, Spring Valley
Galesburg Clinic, Galesburg
Galesburg Cottage Hospital, Galesburg
InterCommunity Cancer Center of Western Illinois, Galesburg
Kewanee Hospital, Kewanee
McDonough District Hospital, Macomb
Graham Hospital, Canton
Eureka Community Hospital, Eureka
Cancer Treatment Center at Pekin Hospital, Pekin
Proctor Hospital, Peoria
CCOP - Illinois Oncology Research Association, Peoria
Oncology Hematology Associates of Central Illinois, PC - Peoria, Peoria
Methodist Medical Center of Illinois, Peoria
St. Joseph Medical Center, Bloomington
Hopedale Medical Complex, Hopedale
BroMenn Regional Medical Center, Normal
Community Cancer Center, Normal
Memorial Hospital, Carthage
Mason District Hospital, Havana
St. John's Regional Health Center, Springfield
Cotton-O'Neil Cancer Center, Topeka
Cancer Center of Kansas, PA - Chanute, Chanute
Cancer Center of Kansas, PA - El Dorado, El Dorado
Cancer Center of Kansas, PA - Salina, Salina
Cancer Center of Kansas, PA - Kingman, Kingman
Cancer Center of Kansas, PA - Newton, Newton
Cancer Center of Kansas, PA - Pratt, Pratt
Cancer Center of Kansas, PA - Wellington, Wellington
Cancer Center of Kansas, PA - Winfield, Winfield
Associates in Womens Health, PA - North Review, Wichita
Cancer Center of Kansas, PA - Medical Arts Tower, Wichita
Cancer Center of Kansas, PA - Wichita, Wichita
CCOP - Wichita, Wichita
Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita
Wesley Medical Center, Wichita
Cancer Center of Kansas, PA - Parsons, Parsons
Cancer Center of Kansas, PA - Dodge City, Dodge City
Southwest Medical Center, Liberal
Methodist Cancer Center at Methodist Hospital - Omaha, Omaha
Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa
Latter Day Saints Hospital, Salt Lake City
Arizona Oncology Services Foundation, Phoenix
University Medical Center of Southern Nevada, Las Vegas
CCOP - Nevada Cancer Research Foundation, Las Vegas
North Bay Cancer Center, Fairfield
Solano Radiation Oncology Center, Vacaville
Enloe Cancer Center at Enloe Medical Center, Chico
Mobile Infirmary Medical Center, Mobile
University of Florida Shands Cancer Center, Gainesville
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida, Tampa
OSF St. Francis Medical Center, Peoria
West Michigan Cancer Center, Kalamazoo
Deaconess Billings Clinic - Downtown, Billings
Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton
Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare, Vineland
Fox Chase Virtua Health Cancer Program at Virtua West Jersey, Voorhees Township
Akron City Hospital, Akron
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia
Reading Hospital and Medical Center, Reading
St. Vincent Hospital Regional Cancer Center, Green Bay
Collaborators (1)
National Cancer Institute (NCI)
NIH
North Central Cancer Treatment Group
NETWORK
Eastern Cooperative Oncology Group
NETWORK
NRG Oncology
OTHER
Radiation Therapy Oncology Group
NETWORK