Combination Chemotherapy With or Without Rituximab in Treating Patients With Relapsed Non-Hodgkin's Lymphoma

PHASE3CompletedINTERVENTIONAL
Enrollment

475

Participants

Timeline

Start Date

May 31, 1999

Primary Completion Date

April 30, 2004

Study Completion Date

July 19, 2017

Conditions
Lymphoma
Interventions
BIOLOGICAL

rituximab

DRUG

CHOP regimen

DRUG

cyclophosphamide

DRUG

doxorubicin hydrochloride

DRUG

prednisone

DRUG

vincristine sulfate

Trial Locations (261)

1

Christchurch Hospital, Christchurch

3

University of Auckland School of Medicine, Auckland

1000

Institut Jules Bordet, Brussels

1125

National Institute of Oncology, Budapest

1577

Mary Potter Oncology Centre, Brooklyn Square

2000

Kennemer Gasthuis - Locatie EG, Haarlem

2010

St. Vincent's Hospital, Sydney

2020

Ziekenhuis Netwerk Antwerpen Middelheim, Antwerp

Waikato Hospital, Hamilton

2031

Institute of Oncology at Prince of Wales Hospital, Randwick

2050

Sydney Cancer Centre at Royal Prince Alfred Hospital, Sydney

2065

Royal North Shore Hospital, St Leonards

2100

Rigshospitalet - Copenhagen University Hospital, Copenhagen

2121

Sandton Oncology Centre, Johannesburg

2139

Concord Repatriation General Hospital, Concord

2145

Westmead Breast Centre at NSW Breast Cancer Institute, Westmead

Westmead Hospital, Westmead

2170

Cancer Therapy Centre at Liverpool Hospital, Liverpool

2193

Medical Oncology Centre of Rosebank, Johannesburg

Johannesburg General Hospital, Parktown

2217

St. George Hospital and Community Health Service, Sydney

2500

Wollongong Hospital, Wollongong

2605

Canberra Hospital, Garran

2610

Algemeen Ziekenhuis Sint-Augustinus, Wilrijk

3050

Royal Melbourne Hospital, Parkville

3058

John Fawkner Hospital, Coburg

3065

St. Vincent's Hospital, Fitzroy

3084

Austin Hospital, Heidelberg

3128

Box Hill Hospital, Box Hill

3181

Alfred Hospital, Melbourne

3199

Frankston Hospital, Frankston

3200

Geelong Hospital, Geelong

3350

St. John of God Hospital, Ballarat

3931

Garden Consulting Rooms, Mornington

4029

Royal Brisbane and Women's Hospital, Brisbane

4066

Wesley Medical Centre, Auchenflower

4102

Princess Alexandra Hospital, Brisbane

4120

Greenslopes Private Hospital, Greenslopes

4810

Townsville General Hospital, Townsville

5000

Royal Adelaide Hospital Cancer Centre, Adelaide

5011

Queen Elizabeth Hospital, Woodville

5035

Ashford Cancer Centre, Ashford

5042

Flinder Medical Centres, Bedford Park

6000

Mount Medical Centre, Perth

Royal Perth Hospital, Perth

6001

St. Jans Gasthuis Weert, Weert Be

6009

Sir Charles Gairdner Hospital - Perth, Perth

6160

Fremantle Hospital, Fremantle

7000

Royal Hobart Hospital, Hobart

7006

St. Olavs University Hospital, Trondheim

7100

Vejle Sygehus, Vejle

8006

Peter MacCallum Cancer Centre, East Melbourne

8800

H. Hartziekenhuis - Roeselaere., Roeselare

33076

Institut Bergonie, Bordeaux

33081

Centro di Riferimento Oncologico - Aviano, Aviano

70185

Orebro University Hospital, Örebro

85186

Sundsvall Hospital, Sundsvall

95128

Sunderby Hospital, Luleå

NSW 2031

Prince of Wales Private Hospital, Randwick

B-2650

Universitair Ziekenhuis Antwerpen, Edegem

B-9000

Algemeen Ziekenhuis Sint Lucas, Ghent

B-3000

U.Z. Gasthuisberg, Leuven

T2N 4N2

Tom Baker Cancer Centre - Calgary, Calgary

T6G 1Z2

Cross Cancer Institute at University of Alberta, Edmonton

V1Y 5L3

British Columbia Cancer Agency - Centre for the Southern Interior, Kelowna

V9S 2B7

Nanaimo Cancer Clinic at Nanaimo Regional General Hospital, Nanaimo

V7L 2P9

Lions Gate Hospital, North Vancouver

V3V 1Z2

Fraser Valley Cancer Centre at British Columbia Cancer Agency, Surrey

V5Z 4E6

British Columbia Cancer Agency - Vancouver Cancer Centre, Vancouver

R3E 0V9

CancerCare Manitoba, Winnipeg

E1C 6ZB

Moncton Hospital, Moncton

A1B 3V6

Newfoundland Cancer Treatment and Research Foundation, St. John's

B3H 1V7

Nova Scotia Cancer Centre at Queen Elizabeth II Health Sciences Centre, Halifax

L4M 6M2

Royal Victoria Hospital of Barrie, Barrie

P3E 5J1

Northeastern Ontario Regional Cancer Centre, Greater Sudbury

L8V 5C2

Margaret and Charles Juravinski Cancer Centre, Hamilton

K7L 5P9

Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston

N6A 4L6

London Regional Cancer Program at London Health Sciences Centre, London

L5B 1B8

Trillium Health Centre - Mississauga Site, Mississauga

K1H 1C4

Ottawa Hospital Regional Cancer Centre - General Campus, Ottawa

L2R 5K3

Hotel Dieu Health Sciences Hospital - Niagara, St. Catharines

P7A 7T1

Northwestern Ontario Regional Cancer Care at Thunder Bay Regional Health Sciences Centre, Thunder Bay

M4N 3M5

Toronto Sunnybrook Regional Cancer Centre at Sunnybrook and Women's College Health Sciences Centre, Toronto

M5G 2M9

Princess Margaret Hospital, Toronto

M6R 1B5

St. Joseph's Health Centre - Toronto, Toronto

M9N 1N8

Humber River Regional Hospital - Weston, Weston

N8W 2X3

Windsor Regional Cancer Centre at Windsor Regional Hospital, Windsor

J4V 2H1

Hopital Charles Lemoyne, Greenfield Park

H1T 2M4

Maisonneuve-Rosemont Hospital, Montreal

H2W 1S6

McGill Cancer Centre at McGill University, Montreal

H4J 1C5

Hopital Du Sacre-Coeur de Montreal, Montreal

H4L 2M1

Hopital Notre- Dame du CHUM, Montreal

G1S 4L8

Hopital du Saint-Sacrement, Quebec, Québec

S4T 7T1

Allan Blair Cancer Centre at Pasqua Hospital, Regina

Unknown

National Cancer Institute of Egypt, Cairo

Albert Schweitzerziekenhuis- Zwijndrecht, Amsterdam

Scheperziekenhuis, Amsterdam

Beatrixziekenhuis, Gorinchem

Martini Ziekenhuis, Groningen

Oudenrijn Ziekenhuis, Utrecht

F-94805

Institut Gustave Roussy, Villejuif

5211 NL

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

1815 JD

Medisch Centrum Alkmaar, Alkmaar

1315RA

Ijselmeer Ziekenhuis - Zuiderzeeziekenhuis, Almere Stad

3016 CP

Meander Medisch Centrum, Amersfont

1006 AE

St. Lucas - Andreas Ziekenhuis, Amsterdam

1007 MB

Vrije Universiteit Medisch Centrum, Amsterdam

1034 CS

Boveny Ziekenhuis, Amsterdam

1066 CX

Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam

1066 EC

Slotervaart Ziekenhuis, Amsterdam

1091 HA

Onze Lieve Vrouwe Gasthuis, Amsterdam

1105 AZ

Academisch Medisch Centrum at University of Amsterdam, Amsterdam

7334 DZ

Gelre Ziekenhuizen - Lokatie Lukas, Apeldoorn

4624 VT

Ziekenhuis Lievensberg, Bergen op Zoom

1261 AN

Streekziekenhuis Gooi-Noord, Blaricum

4800 RL

Amphia Ziekenhuis - locatie Langendijk, Breda

4818 CK

Amphia Ziekenhuis - locatie Molengracht, Breda

6442 BE

Atrium Medical Centre - Brunssum, Brunssum

2906 ZC

Ijsselland Ziekenhuis, Capelle aan den IJssel

NL 2600 GA

Reinier de Graaf Group - Delft, Delft

1782 GZ

Gemini Ziekenhuis, Den Helder

7415 CM

Deventer Ziekenhuisen, Deventer

3247 BW

Van Weel Bethesda Ziekenhuis, Dirksland

NL-9200 DA

NIJ Smellinghe, Drachten

5631 BM

Diaconessenhuis Eindhoven, Eindhoven

7500 KA

Medisch Spectrum Twente, Enschede

NL-5664

St. Anna Ziekenhuis, Geldrop

2803 HH

Groene Hart Ziekenhuis, Gouda

9713 GZ

University Medical Center Groningen, Groningen

2012 CE

Spaarne Ziekenhuis Haarlem, Haarlem

3840 AC

Ziekenhuis St Jansdal, Harderwijk

8440 MA

Tjongerschans Ziekenhuis, Heerenveen

6419 PC

Atrium Medical Centre - Heerlen, Heerlen

5707-HA

Elkerliek Ziekenhuis, Helmond

7555 DL

Streekziekenhuis Midden-Twente, Hengelo

1624 AR

Westfries Gasthuis, Hoorn

NL-4300

Zweedse Rode Kruis Ziekenhuis, La Zierikzee

8934 AD

Medisch Centrum Leeuwarden - Zuid, Leeuwarden

2300 CA

Leiden University Medical Center, Leiden

2300 RD

Diaconessenhuis Leiden, Leiden

2350 CC

Rijnland Ziekenhuis, Leiderdorp

2262 BA

Medisch Centrum Haaglanden Antoniushove, Leidschendam

6202 AZ

Academisch Ziekenhuis Maastricht, Maastricht

NL-7940

Nederlandse Hervormde Diaconessenhuisinrichting, Meppel

3435 CM

Sint Antonius Ziekenhuis, Nieuwegein

NL-6500 HB

Nijmegen Cancer Center at Radboud University Medical Center, Nijmegen

5340 BE

Ziekenhuis Bernhoven, Oss

1440 AG

Waterlandziekenhuis, Purmerend

6043 CV

Saint Laurentius Ziekenhuis, Roermond

4708 AE

Saint Franciscus Ziekenhuis, Roosendaal

3000 CA

University Medical Center Rotterdam at Erasmus Medical Center, Rotterdam

3045 PM

St. Franciscus Gasthuis, Rotterdam

3075 AC

Medisch Centrum Rynmond-Zuid - Lokatie Zuider, Rotterdam

3078 HT

Medisch Centrum Rynmond Zuid - Lokatie: Clara, Rotterdam

NL-3000

Havenziekenhiuis, Rotterdam

NL-3083

Ikazia Ziekenhuis, Rotterdam

6131 BK

Maasland Hospital, Sittard

NL-336

Albert Schweitzerziekenhuis- Sliedrecht, Sliedrecht

NL-3200 GA

Ruwaard Van Putten Ziekenhuis, Spykenisse

NL-9501

Ziekenhuis Refaja, Stadskanaal

NL-4535

Ziekenhuis de Honte, Terneuzen

2545 CH

Hagaziekenhuis, The Hague

2566 MJ

Red Cross Hospital, The Hague

NL-4000

Rivierenland Tiel, Tiel

5022 GC

St. Elisabeth Ziekenhuis, Tilburg

5042 AD

Twee Steden Ziekenhuis Vestiging Tilburg, Tilburg

3584 CX

University Medical Center Utrecht, Utrecht

NL-3563

Mesos Medisch Centrum - Overvecht, Utrecht

NL-5461

St. Joseph Veghel, Veghel

5500 MB

Maxima Medisch Centrum - locatie Eindhoven, Veldhoven

NL-3130 GA

Holy-Ziekenhuis, Vlaardingen

2275 CX

Reinier de Graaf Group - Voorburg, Voorburg

NL-3445

Hofpoort Ziekenhuis, Woerden

1502 DV

Zaans Medisch Centrum, Zaandam

NL-3700

Lorentz Ziekenhuis, Zeist

NL-2700

'T Lange Land Ziekenhuis, Zoetermeer

8000 GK

Isala Klinieken - locatie Sophia, Zwolle

NL-8000 GM

Isala Klinieken - locatie Weezenlanden, Zwolle

N-5021

Haukeland Hospital - University of Bergen, Bergen

N-0310

Norwegian Radium Hospital, Oslo

02-781

Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw

1099-023 Codex

Instituto Portugues de Oncologia de Francisco Gentil - Centro Regional de Oncologia de Lisboa, S.A., Lisbon

833 10

National Cancer Institute - Bratislava, Bratislava

Sl-1000

Institute of Oncology - Ljubljana, Ljubljana

S-413 45

Sahlgrenska University Hospital at Gothenburg University, Gothenburg (Goteborg)

S-581 85

University Hospital of Linkoping, Linköping

S-22185

Lund University Hospital, Lund

S-141 86

Karolinska University Hospital - Huddinge, Stockholm

S-901 85

Umea Universitet, Umeå

HP21 8AL

Stoke Mandeville Hospital, Aylesbury-Buckinghamshire

BA1 3NG

Royal United Hospital, Bath

B18 7QH

City Hospital - Birmingham, Birmingham

B9 5SS

Birmingham Heartlands Hospital, Birmingham

FY3 8NR

Blackpool Victoria Hospital, Blackpool

BH7 7DW

Royal Bournemouth Hospital, Bournemouth

BD9 6RJ

Bradford Hospitals NHS Trust, Bradford

BS2 8ED

Bristol Haematology and Oncology Centre, Bristol

CB2 2QQ

Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust, Cambridge

CT2 7NR

Conquest Hospital, Canterbury

Kent and Canterbury Hospital, Canterbury

SM5 1AA

St Helier Hospital, Carshalton

GL53 7AN

Cheltenham General Hospital, Cheltenham

CH2 1UL

Countess of Chester Hospital, Chester

C03 3NB

Essex County Hospital, Colchester

DN2 5LT

Doncaster Royal Infirmary, Doncaster

DY1 2HQ

Russells Hall Hospital, Dudley

EX2 5DW

Royal Devon and Exeter Hospital, Exeter

NE9 6SX

Queen Elizabeth Hospital, Gateshead

DN33 2BA

Diana Princess of Wales Hospital, Grimsby

NW3 2QG

Royal Free and University College Medical School, Hampstead, London

PE18 6NT

Hinchingbrooke Hospital, Huntingdon

IG3 8YB

King George Hospital, Ilford, Essex

LS1 3EX

Leeds General Infirmary at Leeds Teaching Hospital NHS Trust, Leeds

LE1 5WW

Leicester Royal Infirmary, Leicester

L69 3GA

Royal Liverpool University Hospital, Liverpool

L9 7AL

Aintree University Hospital, Liverpool

EC1A 7BE

Saint Bartholomew's Hospital, London

SE1 9RT

Guy's and St. Thomas' Hospitals NHS Foundation Trust, London

SW17 0QT

St. George's Hospital, London

SW17 ORE

St. Georges Hospital Medical School, London

SW3 6JJ

Royal Marsden NHS Foundation Trust - London, London

WC1E 6AU

University College Hospital, London

CH63 4JY

Clatterbridge Centre for Oncology NHS Trust, Merseyside

TS4 3BW

James Cook University Hospital, Middlesbrough

NE7 7DN

Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne

HA6 2RN

Mount Vernon Cancer Centre at Mount Vernon Hospital, Northwood

NR1 3SR

Norfolk and Norwich University Hospital, Norwich

0X3 9DU

Oxford Radcliffe Hospital, Oxford

P03 6AD

Portsmouth Hospitals NHS Trust, Portsmouth

L35 5DR

Whiston Hospital, Prescot Merseyside

PR2 9HT

Royal Preston Hospital, Preston

RG1 5AN

Berkshire Cancer Centre at Royal Berkshire Hospital, Reading

RM7 OBE

Oldchurch Hospital, Romford

TN2 4QJ

Pembury Hospital, Royal Tunbridge Wells, Kent

SP2 8BJ

Salisbury District Hospital, Salisbury

DN15 7BH

Scunthorpe General Hospital, Scunthorpe

S1O 2SJ

Cancer Research Centre at Weston Park Hospital, Sheffield

SO16 6YD

Southampton General Hospital, Southampton

ST4 7LN

North Staffs Royal Infirmary, Stoke-on-Trent

SM2 5PT

Royal Marsden NHS Foundation Trust - Surrey, Sutton

SA 2 8QA

Singleton Hospital, Swansea

TA1 5DA

Taunton and Somerset Hospital, Taunton Somerset

TQ2 7AA

Torbay Hospital, Torquay Devon

UB8 3NN

Hillingdon Hospital, Uxbridge

B71 4HJ

Sandwell General Hospital, West Bromwich

SO22 5DG

Royal Hampshire County Hospital, Winchester

WV10 0QP

New Cross Hospital, Wolverhampton

BT9 7AB

Belfast City Hospital Trust, Belfast

EH4 2XU

Western General Hospital, Edinburgh

G11 6NT

Western Infirmary, Glasgow

G4 0SF

Royal Infirmary - Castle, Glasgow

G51 4TF

Southern General Hospital, Glasgow

CF14 2TL

Velindre Cancer Center at Velinde Hospital, Cardiff

CF14 4XN

University Hospital of Wales, Cardiff

NP9 2UB

Royal Gwent Hospital, Newport Gwent

LL 18 5UJ

Glan Clywd District General Hospital, Rhyl, Denbighshire

P019 4SE

Saint Richards Hospital, Chichester

HU3 2KZ

Hull Royal Infirmary, Hull

NNI6 8UZ

Kettering General Hosptial, Kettering, Northants

ST16 3SA

Staffordshire General Hospital, Stafford

SN1 4JU

Great Western Hospital, Swindon

Sponsors
All Listed Sponsors
collaborator

Lymphoma Trials Office

OTHER

collaborator

Stichting Hemato-Oncologie voor Volwassenen Nederland

OTHER

collaborator

Australasian Leukaemia and Lymphoma Group

OTHER

collaborator

NCIC Clinical Trials Group

NETWORK

collaborator

Nordic Lymphoma Group

NETWORK

lead

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK

NCT00004179 - Combination Chemotherapy With or Without Rituximab in Treating Patients With Relapsed Non-Hodgkin's Lymphoma | Biotech Hunter | Biotech Hunter