Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Aggressive Non-Hodgkin's Lymphoma

PHASE3CompletedINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

April 30, 1997

Primary Completion Date

March 31, 2004

Study Completion Date

March 31, 2004

Conditions
Lymphoma
Interventions
BIOLOGICAL

filgrastim

DRUG

CHOP regimen

DRUG

cyclophosphamide

DRUG

cytarabine

DRUG

doxorubicin hydrochloride

DRUG

etoposide

DRUG

leucovorin calcium

DRUG

melphalan

DRUG

methotrexate

DRUG

methylprednisolone

DRUG

mitoxantrone hydrochloride

DRUG

prednisone

DRUG

therapeutic hydrocortisone

DRUG

vincristine sulfate

PROCEDURE

bone marrow ablation with stem cell support

PROCEDURE

peripheral blood stem cell transplantation

RADIATION

radiation therapy

Trial Locations (12)

1011

Centre Hospitalier Universitaire Vaudois, Lausanne

11522

Saint Savvas Cancer Hospital of Athens, Athens

20141

European Institute of Oncology, Milan

A-1090

Allgemeines Krankenhaus der Stadt Wien, Vienna

D-65199

Dr. Horst-Schmidt-Kliniken, Wiesbaden

CH-4031

Universitatsspital-Basel, Basel

CH-6500

Oncology Institute of Southern Switzerland, Bellinzona

CH-3010

Inselspital, Bern, Bern

CH-7000

Ratisches Kantons und Regionalspital, Chur

CH-1245

Hopital Cantonal Universitaire de Geneve, Collonge-Bellerive

CH-9007

Kantonsspital - St. Gallen, Sankt Gallen

CH-8008

Klinik Hirslanden, Zurich

All Listed Sponsors
lead

Swiss Cancer Institute

OTHER