Combination Chemotherapy in Treating Children With Progressive Brain Tumors

PHASE3CompletedINTERVENTIONAL
Enrollment

428

Participants

Timeline

Start Date

April 30, 1997

Primary Completion Date

February 28, 2006

Study Completion Date

April 30, 2012

Conditions
Brain TumorsCentral Nervous System Tumors
Interventions
DRUG

carboplatin

Given IV

DRUG

lomustine

Given IV

DRUG

procarbazine hydrochloride

Given PO

DRUG

thioguanine

Given PO

DRUG

vincristine sulfate

Given PO and IV

Trial Locations (204)

1

Starship Children's Health, Auckland

1205

Swiss Pediatric Oncology Group Geneva, Geneva

2031

Prince of Wales Private Hospital, Randwick

2145

Children's Hospital at Westmead, Westmead

2310

John Hunter Hospital, Newcastle

3010

Swiss Pediatric Oncology Group Bern, Bern

4029

Royal Children's Hospital, Brisbane

6001

Princess Margaret Hospital for Children, Perth

10016

NYU Cancer Institute at New York University Medical Center, New York

10027

St. Luke's - Roosevelt Hospital Center - St.Luke's Division, New York

10032

Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York

10065

Memorial Sloan-Kettering Cancer Center, New York

10461

Albert Einstein Cancer Center at Albert Einstein College of Medicine, The Bronx

10595

New York Medical College, Valhalla

11030

Don Monti Comprehensive Cancer Center at North Shore University Hospital, Manhasset

11040

Schneider Children's Hospital, New Hyde Park

11219

Maimonides Cancer Center at Maimonides Medical Center, Brooklyn

13210

SUNY Upstate Medical University Hospital, Syracuse

14642

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester

15213

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

19803

Alfred I. duPont Hospital for Children, Wilmington

20007

Lombardi Comprehensive Cancer Center at Georgetown University Medical Center, Washington D.C.

21201

Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore

21215

Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore

24014

Carilion Medical Center for Children at Roanoke Community Hospital, Roanoke

25302

West Virginia University Health Sciences Center - Charleston, Charleston

25701

Edwards Comprehensive Cancer Center at Cabell Huntington Hospital, Huntington

26506

Mary Babb Randolph Cancer Center at West Virginia University Hospitals, Morgantown

29203

Palmetto Health South Carolina Cancer Center, Columbia

29425

Hollings Cancer Center at Medical University of South Carolina, Charleston

30322

AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus, Atlanta

30342

AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus, Atlanta

31208

Medical Center of Central Georgia, Macon

32207

Nemours Children's Clinic, Jacksonville

32504

Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola

32806

M.D. Anderson Cancer Center at Orlando, Orlando

Nemours Children's Clinic - Orlando, Orlando

33021

Memorial Cancer Institute at Memorial Regional Hospital, Hollywood

33155

Miami Children's Hospital, Miami

33176

Baptist-South Miami Regional Cancer Program, Miami

33316

Broward General Medical Center Cancer Center, Fort Lauderdale

33407

Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach

33607

St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa

33701

All Children's Hospital, St. Petersburg

33901

Lee Cancer Care of Lee Memorial Health System, Fort Myers

36604

University of South Alabama Mitchell Cancer Institute, Mobile

37901

East Tennessee Children's Hospital, Knoxville

40232

Kosair Children's Hospital, Louisville

43606

Toledo Hospital, Toledo

43614

Medical University of Ohio Cancer Center, Toledo

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

44501

Tod Children's Hospital, Youngstown

46260

St. Vincent Indianapolis Hospital, Indianapolis

48073

William Beaumont Hospital - Royal Oak Campus, Royal Oak

48236

Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods

48503

Hurley Medical Center, Flint

48910

Breslin Cancer Center at Ingham Regional Medical Center, Lansing

50309

Blank Children's Hospital, Des Moines

54449

Marshfield Clinic - Marshfield Center, Marshfield

54601

Gundersen Lutheran Center for Cancer and Blood, La Crosse

55404

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55455

Masonic Cancer Center at University of Minnesota, Minneapolis

55905

Mayo Clinic Cancer Center, Rochester

57105

Avera Cancer Institute, Sioux Falls

58122

CCOP - MeritCare Hospital, Fargo

60153

Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood

60453

Keyser Family Cancer Center at Advocate Hope Children's Hospital, Oak Lawn

60612

Rush University Medical Center, Chicago

60614

Children's Memorial Hospital - Chicago, Chicago

61637

Saint Jude Midwest Affiliate, Peoria

63104

Cardinal Glennon Children's Hospital, St Louis

63110

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis

64108

Children's Mercy Hospital, Kansas City

65203

Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia

67214

Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita

Wesley Medical Center, Wichita

70118

Children's Hospital of New Orleans, New Orleans

70121

Ochsner Cancer Institute at Ochsner Clinic Foundation, New Orleans

72205

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock

73104

Oklahoma University Cancer Institute, Oklahoma City

76104

Cook Children's Medical Center - Fort Worth, Fort Worth

76508

CCOP - Scott and White Hospital, Temple

78207

University of Texas Health Science Center at San Antonio, San Antonio

78411

Driscoll Children's Hospital, Corpus Christi

78723

Dell Children's Medical Center of Central Texas, Austin

79106

Texas Tech University Health Sciences Center School of Medicine - Amarillo, Amarillo

79410

Covenant Children's Hospital, Lubbock

80045

Children's Hospital Center for Cancer and Blood Disorders, Aurora

90027

Southern California Permanente Medical Group, Downey

Childrens Hospital Los Angeles, Los Angeles

90801

Jonathan Jaques Children's Cancer Center at Miller Children's Hospital, Long Beach

92354

Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda

92868

Children's Hospital of Orange County, Orange

93105

Santa Barbara Cottage Children's Hospital, Santa Barbara

94115

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

94609

Children's Hospital and Research Center Oakland, Oakland

95798

Lucile Packard Children's Hospital at Stanford University Medical Center, Palo Alto

95816

Sutter Cancer Center, Sacramento

95817

University of California Davis Cancer Center, Sacramento

95825

Kaiser Permanente Medical Center - Oakland, Sacramento

96813

Cancer Research Center of Hawaii, Honolulu

97227

Legacy Emanuel Hospital and Health Center and Children's Hospital, Portland

98105

Children's Hospital and Regional Medical Center - Seattle, Seattle

98112

Group Health Central Hospital, Seattle

98405

Mary Bridge Children's Hospital and Health Center - Tacoma, Tacoma

98431

Madigan Army Medical Center - Tacoma, Tacoma

85016-7710

Phoenix Children's Hospital, Phoenix

91010-3000

City of Hope Comprehensive Cancer Center, Duarte

90048-1865

Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles

90095-1781

Jonsson Comprehensive Cancer Center at UCLA, Los Angeles

93638-8762

Children's Hospital Central California, Madera

92123-4282

Rady Children's Hospital - San Diego, San Diego

95051-5386

Kaiser Permanente Medical Center - Santa Clara Kiely Campus, Santa Clara

06360-2875

Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington

06520-8028

Yale Cancer Center, New Haven

20010-2970

Children's National Medical Center, Washington D.C.

32610-0232

University of Florida Shands Cancer Center, Gainesville

32803-1273

Florida Hospital Cancer Institute at Florida Hospital Orlando, Orlando

30912-3730

MBCCOP - Medical College of Georgia Cancer Center, Augusta

31403-3089

Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah

83712-6297

Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise

60612-7243

University of Illinois Cancer Center, Chicago

60637-1470

University of Chicago Cancer Research Center, Chicago

60068-1174

Advocate Lutheran General Cancer Care Center, Park Ridge

61104-2315

Swedish-American Regional Cancer Center, Rockford

62794-9677

Simmons Cooper Cancer Institute, Springfield

46202-5289

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

52242-1002

Holden Comprehensive Cancer Center at University of Iowa, Iowa City

66160-7357

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City

67214-3882

CCOP - Wichita, Wichita

40536-0093

Lucille P. Markey Cancer Center at University of Kentucky, Lexington

71315-3198

Tulane Cancer Center Office of Clinical Research, Alexandria

04401

CancerCare of Maine at Eastern Maine Medical Center, Bangor

04074-9308

Maine Children's Cancer Program at Barbara Bush Children's Hospital, Scarborough

02115

Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute, Boston

01199-0001

Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield

48109-0286

C.S. Mott Children's Hospital at University of Michigan Medical Center, Ann Arbor

48201-1379

Barbara Ann Karmanos Cancer Institute, Detroit

49503-2560

Butterworth Hospital at Spectrum Health, Grand Rapids

49007-5381

CCOP - Kalamazoo, Kalamazoo

55805-1983

CCOP - Duluth, Duluth

55102-2392

Children's Hospitals and Clinics of Minnesota - St. Paul, Saint Paul

39216-4505

University of Mississippi Cancer Clinic, Jackson

39534-2511

Keesler Air Force Base Medical Center, Keesler Air Force Base

68114-4113

Children's Hospital, Omaha

89109-2306

CCOP - Nevada Cancer Research Foundation, Las Vegas

07601

Hackensack University Medical Center Cancer Center, Hackensack

07039

St. Barnabas Medical Center Cancer Center, Livingston

07962

Overlook Hospital, Morristown

08901

Saint Peter's University Hospital, New Brunswick

08903

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

07503

St. Joseph's Hospital and Medical Center, Paterson

87131-5636

University of New Mexico Cancer Center, Albuquerque

12208-3419

Albany Medical Center Hospital, Albany

14263-0001

Roswell Park Cancer Institute, Buffalo

10003-3803

Beth Israel Medical Center - Petrie Division, New York

11794-9446

Stony Brook University Cancer Center, Stony Brook

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

28232-2861

Blumenthal Cancer Center at Carolinas Medical Center, Charlotte

28233-3549

Presbyterian Cancer Center at Presbyterian Hospital, Charlotte

58103-4940

Dakota Cancer Institute at Dakota Clinic - South University, Fargo

44308-1062

Akron Children's Hospital, Akron

45229-3039

Cincinnati Children's Hospital Medical Center, Cincinnati

44106-5000

Rainbow Babies and Children's Hospital, Cleveland

43205-2696

Nationwide Children's Hospital, Columbus

45404-1815

Dayton Children's - Dayton, Dayton

97239-3098

Knight Cancer Institute at Oregon Health and Science University, Portland

17822-0001

Geisinger Cancer Institute at Geisinger Health, Danville

17033-0850

Penn State Children's Hospital, Hershey

19104-9786

Children's Hospital of Philadelphia, Philadelphia

19134-1095

St. Christopher's Hospital for Children, Philadelphia

57117-5039

Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls

37232-6838

Vanderbilt-Ingram Cancer Center, Nashville

77555-0361

University of Texas Medical Branch, Galveston

77030-4009

M. D. Anderson Cancer Center at University of Texas, Houston

78236-5300

Wilford Hall Medical Center, Lackland Air Force Base

78229-3993

Methodist Children's Hospital of South Texas, San Antonio

84113-1100

Primary Children's Medical Center, Salt Lake City

05401

Fletcher Allen Health Care - University Health Center Campus, Burlington

22042-3300

Inova Fairfax Hospital, Falls Church

23507-1971

Children's Hospital of The King's Daughters, Norfolk

23708-2197

Naval Medical Center - Portsmouth, Portsmouth

23298-0037

Virginia Commonwealth University Massey Cancer Center, Richmond

99210-0248

Deaconess Medical Center, Spokane

99220-2555

Providence Cancer Center at Sacred Heart Medical Center, Spokane

54307-3508

St. Vincent Hospital Regional Cancer Center, Green Bay

T3B 6A8

Alberta Children's Hospital, Calgary

T6G 1Z2

University of Alberta Hospital, Edmonton

V6H 3V4

Children's & Women's Hospital of British Columbia, Vancouver

R3E 0V9

CancerCare Manitoba, Winnipeg

A1B 3V6

Janeway Children's Health and Rehabilitation Centre, St. John's

B3J 3G9

IWK Health Centre, Halifax

L8N 3Z5

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton

K7L 2V7

Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston

N6A 5W9

Children's Hospital of Western Ontario, London

K1H 8L1

Children's Hospital of Eastern Ontario, Ottawa

M5G 1X8

Hospital for Sick Children, Toronto

H3H 1P3

Montreal Children's Hospital at McGill University Health Center, Montreal

H3T 1C5

Hopital Sainte Justine, Montreal

S4T 7T1

Allan Blair Cancer Centre at Pasqua Hospital, Regina

S7N 4H4

Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon

G1V 4G2

Centre Hospitalier Universitaire de Quebec, Québec

9713 EZ

University Medical Center Groningen, Groningen

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK