Antibiotic Therapy in Preventing Early Infection in Patients With Multiple Myeloma Who Are Receiving Chemotherapy

PHASE3CompletedINTERVENTIONAL
Enrollment

212

Participants

Timeline

Start Date

March 31, 1997

Primary Completion Date

April 30, 2011

Study Completion Date

January 31, 2012

Conditions
InfectionMultiple Myeloma
Interventions
DRUG

ciprofloxacin

Begin oral ciprofloxacin when they start chemotherapy for multiple myeloma. Assigned treatment consists of ciprofloxacin (Cipro 500 mg po tablet every 12 hours for two months. The patient will continue to be observed one additional month on study continuing regular myeloma chemotherapy.

DRUG

ofloxacin

Begin oral ofloxacin when they start chemotherapy for multiple myeloma. Assigned treatment consists of ofloxacin (500 mg po tablet every 12 hours for two months. The patient will continue to be observed one additional month on study continuing regular myeloma chemotherapy.

DRUG

160 mg trimethoprim and 800 mg sulfamethoxazole

Begin oral TMP-SMX when they start chemotherapy for multiple myeloma. Assigned treatment consists of TMP-SMX (Septra® or Bactrim®) 1 DS tablet \[TMP-SMX DS = 160 mg trimethoprim and 800 mg sulfamethoxazole\] every 12 hours for two months..

Trial Locations (45)

10011

St. Vincent's Comprehensive Cancer Center - Manhattan, New York

10466

Our Lady of Mercy Medical Center Comprehensive Cancer Center, The Bronx

13057

CCOP - Hematology-Oncology Associates of Central New York, East Syracuse

16803

Mount Nittany Medical Center, State College

17044

Lewistown Hospital, Lewistown

19380

Chester County Hospital, West Chester

29615

CCOP - Greenville, Greenville

36606

MBCCOP - Gulf Coast, Mobile

43215

CCOP - Columbus, Columbus

44109

MetroHealth Cancer Care Center at MetroHealth Medical Center, Cleveland

44708

Mercy Cancer Center at Mercy Medical Center, Canton

45429

CCOP - Dayton, Dayton

49431

Green Bay Oncology, Limited - Escanaba, Escanaba

49801

Dickinson County Healthcare System, Iron Mountain

51101

Siouxland Hematology-Oncology Associates, LLP, Sioux City

51104

Mercy Medical Center - Sioux City, Sioux City

St. Luke's Regional Medical Center, Sioux City

52403

Cedar Rapids Oncology Associates, Cedar Rapids

52501

McCreery Cancer Center at Ottumwa Regional, Ottumwa

54143

Bay Area Cancer Care Center at Bay Area Medical Center, Marinette

54154

Green Bay Oncology, Limited - Oconto Falls, Oconto Falls

54235

Green Bay Oncology, Limited - Sturgeon Bay, Sturgeon Bay

54303

Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay

St. Mary's Hospital Medical Center - Green Bay, Green Bay

54449

CCOP - Marshfield Clinic Research Foundation, Marshfield

55416

CCOP - Metro-Minnesota, Saint Louis Park

55905

Mayo Clinic Cancer Center, Rochester

57105

Avera Cancer Institute, Sioux Falls

Medical X-Ray Center, PC, Sioux Falls

64131

CCOP - Kansas City, Kansas City

97225

CCOP - Columbia River Oncology Program, Portland

36652-2144

Mobile Infirmary Medical Center, Mobile

67214-3882

CCOP - Wichita, Wichita

02215

Beth Israel Deaconess Medical Center, Boston

49007-3731

CCOP - Kalamazoo, Kalamazoo

08822

Hunterdon Regional Cancer Center at Hunterdon Medical Center, Flemington

08865

Warren Hospital, Phillipsburg

27534-9479

CCOP - Southeast Cancer Control Consortium, Goldsboro

17033-0850

Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey

57117-5039

Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls

98405-0986

CCOP - Northwest, Tacoma

54301-3526

Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center, Green Bay

54307-3508

St. Vincent Hospital Regional Cancer Center, Green Bay

Lima 34

Instituto Nacional de Enfermedades Neoplasicas, Lima

0001

Pretoria Academic Hospital, Pretoria

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Eastern Cooperative Oncology Group

NETWORK

lead

Gary Morrow

OTHER