Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia

PHASE3CompletedINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

December 31, 1996

Primary Completion Date

November 30, 2002

Study Completion Date

April 30, 2006

Conditions
Leukemia
Interventions
DRUG

cytarabine

Given IV

DRUG

dexamethasone

Given IV

DRUG

etoposide

Given IV

DRUG

idarubicin

Given IV

DRUG

ifosfamide

Given IV

DRUG

leucovorin calcium

DRUG

mesna

Given IV

DRUG

pegaspargase

Given IV

DRUG

therapeutic hydrocortisone

DRUG

thioguanine

DRUG

vincristine sulfate

Given IV

RADIATION

low-LET cobalt-60 gamma ray therapy

RADIATION

low-LET electron therapy

RADIATION

low-LET photon therapy

DRUG

Methotrexate

Given IV

Trial Locations (33)

6001

Princess Margaret Hospital for Children, Perth

10016

Kaplan Cancer Center, New York

10021

Memorial Sloan-Kettering Cancer Center, New York

10032

Herbert Irving Comprehensive Cancer Center, New York

15213

Children's Hospital of Pittsburgh, Pittsburgh

19104

Children's Hospital of Philadelphia, Philadelphia

52242

University of Iowa Hospitals and Clinics, Iowa City

53792

University of Wisconsin Comprehensive Cancer Center, Madison

55455

University of Minnesota Cancer Center, Minneapolis

55905

Mayo Clinic Cancer Center, Rochester

60637

University of Chicago Cancer Research Center, Chicago

64108

Children's Mercy Hospital - Kansas City, Kansas City

80218

Children's Hospital of Denver, Denver

84132

Huntsman Cancer Institute, Salt Lake City

90806

Long Beach Memorial Medical Center, Long Beach

92668

Children's Hospital of Orange County, Orange

98105

Children's Hospital and Regional Medical Center - Seattle, Seattle

98109

Fred Hutchinson Cancer Research Center, Seattle

90027-0700

Children's Hospital Los Angeles, Los Angeles

90095-1781

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles

94115-0128

UCSF Cancer Center and Cancer Research Institute, San Francisco

20010-2970

Children's National Medical Center, Washington D.C.

46202-5265

Indiana University Cancer Center, Indianapolis

48109-0752

University of Michigan Comprehensive Cancer Center, Ann Arbor

68198-3330

University of Nebraska Medical Center, Omaha

27599-7295

Lineberger Comprehensive Cancer Center, UNC, Chapel Hill

45229-3039

Children's Hospital Medical Center - Cincinnati, Cincinnati

44106-5065

Ireland Cancer Center, Cleveland

43205-2696

Children's Hospital of Columbus, Columbus

97201-3098

Doernbecher Children's Hospital, Portland

37232-6838

Vanderbilt Cancer Center, Nashville

V6H 3V4

British Columbia Children's Hospital, Vancouver

B3J 3G9

IWK Grace Health Centre, Halifax

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT00002816 - Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia | Biotech Hunter | Biotech Hunter