Standard Chemotherapy Compared With High-Dose Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Women With Breast Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

600

Participants

Timeline

Start Date

November 30, 1995

Study Completion Date

June 30, 1999

Conditions
Breast Cancer
Interventions
BIOLOGICAL

filgrastim

DRUG

CMF regimen

DRUG

cyclophosphamide

DRUG

doxorubicin hydrochloride

DRUG

fluorouracil

DRUG

methotrexate

DRUG

tamoxifen citrate

DRUG

thiotepa

PROCEDURE

autologous bone marrow transplantation

PROCEDURE

peripheral blood stem cell transplantation

RADIATION

low-LET cobalt-60 gamma ray therapy

RADIATION

low-LET electron therapy

RADIATION

low-LET photon therapy

Trial Locations (21)

4

St. Vincent's Hospital, Dublin

CB2 2QQ

Addenbrooke's NHS Trust, Cambridge

GL53 7AN

Cheltenham General Hospital, Cheltenham

EX2 5DW

Royal Devon and Exeter Hospital, Exeter

NW3 2QG

Royal Free Hospital, Hampstead, London

HA1 3UJ

Northwick Park Hospital, Harrow

HD3 3EA

Huddersfield Royal Infirmary, Huddersfield, West Yorks

LS9 7TF

St. James's Hospital, Leeds

SW17 0QT

St. George's Hospital, London

W1N 8AA

Middlesex Hospital- Meyerstein Institute, London

NE4 6BE

Newcastle General Hospital, Newcastle upon Tyne

NG5 1PB

Nottingham City Hospital NHS Trust, Nottingham

PL6 8DH

Derriford Hospital, Plymouth

S1O 2SJ

Weston Park Hospital, Sheffield

SO14 0YG

Royal South Hants Hospital, Southampton

AB25 2ZN

Aberdeen Royal Infirmary, Aberdeen

EH3 9YW

Royal Infirmary, Edinburgh

EH4 9NQ

Western General Hospital, Edinburgh

G11 6NT

Beatson Oncology Centre, Glasgow

G4 0SF

Royal Infirmary, Glasgow

CF4 7XL

Velindre Hospital, Cardiff

All Listed Sponsors
lead

Scottish Cancer Therapy Network

OTHER

NCT00002755 - Standard Chemotherapy Compared With High-Dose Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Women With Breast Cancer | Biotech Hunter | Biotech Hunter