50
Participants
Start Date
July 31, 1995
Primary Completion Date
December 31, 2001
Study Completion Date
December 31, 2003
asparaginase
10,000 units/d IV or IM 15 - 24
cyclophosphamide
con: 650 mg/m2 IV 1, 15, 29 maint: 650 mg/m2 IV 1
cytarabine
cons: 75 mg/m2/d IV Push 2 - 5, 9 - 12, 6 - 19, 23 - 26
daunorubicin hydrochloride
ind: 60 mg/m2 IV 22 and 23
dexamethasone
main: 10 mg/m2/day PO 1 - 28
doxorubicin hydrochloride
main: 25 mg/m2 IV 1, 8, 15, and 22
etoposide
60 mg/kg based on ideal body weight day -3
leucovorin calcium
5 mg q 6 hours for 4 doses, PO 1, 3, 8, 11 after each methotrexate if WBC \< 3,000 /μl
mercaptopurine
con: 60 mg/m2 PO 1 - 28
methotrexate
10 mg/m2 IT or IV, d 2, 9, 16, and 23; Maximum 15 mg/admin
prednisone
"ind: 60 mg/m2/d PO 1 - 21\*, 22 - 28 Patients will receive full dose through day 8 and then tapered to zero between Day 29 and 42.~ind2: 60 mg/m2/d PO through day 42"
thioguanine
main: 60 mg/m2/day PO 1 - 14
vincristine sulfate
ind: 1.4 mg/m2 2 mg max, IV 1, 8, 15, and 22 ind2: 1.4 mg/m2 2 mg max IV 29 and 36 main: 1.5 mg/m2 2 mg max, IV 1, 8, 15, and 22
allogeneic bone marrow transplantation
day 0
radiation therapy
day -7 through day -4 total dose of radiation is 1,320 cGy.
Herbert Irving Comprehensive Cancer Center, New York
Veterans Affairs Medical Center - Brooklyn, Brooklyn
CCOP - Upstate Carolina, Spartanburg
CCOP - Greenville, Greenville
MBCCOP - University of South Alabama, Mobile
Veterans Affairs Medical Center - Jackson, Jackson
CCOP - Columbus, Columbus
Cleveland Clinic Cancer Center, Cleveland
Barrett Cancer Center, The University Hospital, Cincinnati
Veterans Affairs Medical Center - Dayton, Dayton
CCOP - Dayton, Kettering
Veterans Affairs Medical Center - Ann Arbor, Ann Arbor
Barbara Ann Karmanos Cancer Institute, Detroit
Henry Ford Hospital, Detroit
CCOP - Grand Rapids Clinical Oncology Program, Grand Rapids
CCOP - Montana Cancer Consortium, Billings
Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital), Hines
Loyola University Medical Center, Maywood
CCOP - Central Illinois, Springfield
CCOP - St. Louis-Cape Girardeau, St Louis
Veterans Affairs Medical Center - Kansas City, Kansas City
CCOP - Kansas City, Kansas City
CCOP - Cancer Research for the Ozarks, Springfield
Veterans Affairs Medical Center - Wichita, Wichita
MBCCOP - LSU Medical Center, New Orleans
Tulane University School of Medicine, New Orleans
Veterans Affairs Medical Center - New Orleans, New Orleans
Veterans Affairs Medical Center - Shreveport, Shreveport
University of Arkansas for Medical Sciences, Little Rock
Veterans Affairs Medical Center - Little Rock (McClellan), Little Rock
Oklahoma Medical Research Foundation, Oklahoma City
Veterans Affairs Medical Center - Oklahoma City, Oklahoma City
Veterans Affairs Medical Center - Temple, Temple
CCOP - Scott and White Hospital, Temple
Brooke Army Medical Center, Fort Sam Houston
University of Texas Health Science Center at San Antonio, San Antonio
Veterans Affairs Medical Center - San Antonio (Murphy), San Antonio
Texas Tech University Health Science Center, Lubbock
Veterans Affairs Medical Center - Denver, Denver
University of Colorado Cancer Center, Denver
Huntsman Cancer Institute, Salt Lake City
Veterans Affairs Medical Center - Salt Lake City, Salt Lake City
Veterans Affairs Medical Center - Phoenix (Hayden), Phoenix
Veterans Affairs Medical Center - Tucson, Tucson
Arizona Cancer Center, Tucson
University of New Mexico Cancer Research & Treatment Center, Albuquerque
Veterans Affairs Medical Center - Long Beach, Long Beach
Beckman Research Institute, City of Hope, Duarte
David Grant Medical Center, Travis Air Force Base
Veterans Affairs Outpatient Clinic - Martinez, Martinez
CCOP - Santa Rosa Memorial Hospital, Santa Rosa
University of California Davis Medical Center, Sacramento
Cancer Research Center of Hawaii, Honolulu
Veterans Affairs Medical Center - Portland, Portland
CCOP - Columbia River Program, Portland
CCOP - Virginia Mason Research Center, Seattle
Swedish Cancer Institute, Seattle
Veterans Affairs Medical Center - Seattle, Seattle
CCOP - Greater Phoenix, Phoenix
USC/Norris Comprehensive Cancer Center, Los Angeles
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles
CCOP - Bay Area Tumor Institute, Oakland
CCOP - Atlanta Regional, Atlanta
Dwight David Eisenhower Army Medical Center, Fort Gordon
University of Kansas Medical Center, Kansas City
CCOP - Wichita, Wichita
Veterans Affairs Medical Center - Lexington, Lexington
Albert B. Chandler Medical Center, University of Kentucky, Lexington
Louisiana State University Hospital - Shreveport, Shreveport
Boston Medical Center, Boston
Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain
University of Michigan Comprehensive Cancer Center, Ann Arbor
Veterans Affairs Medical Center - Detroit, Detroit
Providence Hospital - Southfield, Southfield
Veterans Affairs Medical Center - Biloxi, Biloxi
University of Mississippi Medical Center, Jackson
Keesler Medical Center - Keesler AFB, Keesler Air Force Base
St. Louis University Health Sciences Center, St Louis
Veterans Affairs Medical Center - Albuquerque, Albuquerque
Veterans Affairs Medical Center - Cincinnati, Cincinnati
Oregon Cancer Center at Oregon Health Sciences University, Portland
University of Texas Medical Branch, Galveston
CCOP - Northwest, Tacoma
National Cancer Institute (NCI)
NIH
SWOG Cancer Research Network
NETWORK