3,031
Participants
Start Date
July 31, 1995
Primary Completion Date
June 30, 2002
Study Completion Date
August 31, 2003
dactinomycin
filgrastim
cyclophosphamide
doxorubicin hydrochloride
Source and Pharmacology: An anthracycline antibiotic isolated from cultures of Streptomyces peucetius. Binds to DNA and inhibits nucleic acid synthesis, with its major lethal effect occurring during the S phase of the cell cycle. Has some topoisomerase II inhibitory activity. Since it is primarily excreted by the liver, any liver impairment may enhance toxicity. 40% to 50% is excreted in the bile; \<5% in the urine. The drug has a very short initial t½ of \<20 minutes and a terminal t½ of 17 hours. Animal studies indicate cytotoxic levels persist in tissue for as long as 24 hours.
etoposide
vincristine sulfate
conventional surgery
radiation therapy
Sydney Children's Hospital, Randwick
Children's Hospital at Westmead, Westmead
Royal Children's Hospital, Parkville
Royal Children's Hospital, Brisbane
Women's and Children's Hospital, North Adelaide
Princess Margaret Hospital for Children, Perth
Memorial Sloan-Kettering Cancer Center, New York
Mount Sinai School of Medicine, New York
Columbia Presbyterian Hospital, New York
Albert Einstein Clinical Cancer Center, The Bronx
New York Medical College, Valhalla
North Shore University Hospital, Manhasset
Schneider Children's Hospital, New Hyde Park
Brooklyn Hospital Center, Brooklyn
State University of New York Health Science Center at Brooklyn College of Medicine, Brooklyn
Brookdale University Hospital and Medical Center, Brooklyn
Maimonides Medical Center, Brooklyn
Cancer Center of Albany Medical Center, Albany
State University of New York - Upstate Medical University, Syracuse
James P. Wilmot Cancer Center, Rochester
Children's Hospital of Pittsburgh, Pittsburgh
Children's Hospital of Philadelphia, Philadelphia
Alfred I. Dupont Institute, Wilmington
Lombardi Cancer Center, Washington D.C.
Sinai Hospital of Baltimore, Baltimore
Cancer Center at the University of Virginia, Charlottesville
Children's Hospital of the King's Daughters, Norfolk
Carilion Medical Center for Children, Roanoke
West Virginia University - Charleston, Charleston
Cabell-Huntington Hospital, Inc, Huntington
Duke Comprehensive Cancer Center, Durham
Mission Saint Joseph's Health System, Asheville
Palmetto Health South Carolina Cancer Center, Columbia
Children's Hospital of Greenville Hospital System, Greenville
Emory University Hospital - Atlanta, Atlanta
Children's Healthcare of Atlanta - Scottish Rite, Atlanta
Medical Center of Central Georgia, Macon
Nemours Children's Clinic, Jacksonville
Sacred Heart Children's Hospital, Pensacola
Florida Hospital Cancer Institute, Orlando
Nemours Children's Clinic-Orlando, Orlando
Joe DiMaggio Children's Hospital at Memorial, Hollywood
University of Miami-Jackson Memorial Hospital, Miami
Broward General Medical Center, Fort Lauderdale
St. Mary's Hospital, West Palm Beach
All Children's Hospital, St. Petersburg
Children's Hospital of Southwest Florida, Fort Myers
University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham
University of South Alabama Medical Center, Mobile
East Tennessee State University Cancer Center at JCMC, Johnson City
East Tennessee Children's Hospital, Knoxville
Toledo Children's Hospital, Toledo
St. Vincent Mercy Medical Center, Toledo
Cleveland Clinic Taussig Cancer Center, Cleveland
Children's Hospital Medical Center of Akron, Akron
Forum Health-Tod Childrens Hospital, Youngstown
Children's Medical Center - Dayton, Dayton
St. Vincent Hospital and Health Care Center, Indianapolis
Children's Hospital of Michigan, Detroit
Henry Ford Hospital, Detroit
St. John Hospital and Medical Center, Detroit
Hurley Medical Center, Flint
Michigan State University, East Lansing
Bronson Methodist Hospital, Kalamazoo
Spectrum Health and DeVos Children's Hospital, Grand Rapids
Raymond Blank Memorial Hospital for Children, Des Moines
John Stoddard Cancer Center, Des Moines
Midwest Children's Cancer Center, Milwaukee
Bellin Memorial Hospital, Green Bay
CCOP - St. Vincent Hospital Cancer Center, Green Bay, Green Bay
Gundersen Lutheran Medical Center, La Crosse
Children's Hospitals and Clinics of Minnesota, Saint Paul
Children's Hospitals and Clinics - Minneapolis, Minneapolis
Mayo Clinic Cancer Center, Rochester
Sioux Valley Hospital, Sioux Falls
Hope Children's Hospital, Oak Lawn
University of Chicago Cancer Research Center, Chicago
Rush-Presbyterian-St. Luke's Medical Center, Chicago
University of Illinois at Chicago, Chicago
Children's Memorial Hospital - Chicago, Chicago
Saint Jude Midwest Affiliate, Peoria
Cardinal Glennon Children's Hospital, St Louis
St. Louis Children's Hospital, St Louis
Children's Mercy Hospital, Kansas City
Wesley Medical Center, Wichita
Children's Hospital of Omaha, Omaha
Tulane University School of Medicine, New Orleans
Children's Hospital of New Orleans, New Orleans
Ochsner Clinic, New Orleans
University of Arkansas for Medical Sciences, Little Rock
Children's Hospital of Oklahoma, Oklahoma City
CCOP - Oklahoma, Tulsa
Natalie Warren Bryant Cancer Center, Tulsa
Medical City Dallas Hospital, Dallas
Cook Children's Medical Center - Fort Worth, Fort Worth
Scott and White Memorial Hospital, Temple
Baylor College of Medicine, Houston
University of Texas Health Science Center at San Antonio, San Antonio
Children's Hospital of Austin, Austin
Texas Tech University Health Sciences Center School of Medicine, Amarillo
Covenant Children's Hospital, Lubbock
Childhood Hematology/Oncology Associates, Denver
Presbyterian-St Luke's Medical Center, Denver
Mountain States Tumor Institute, Boise
Huntsman Cancer Institute, Salt Lake City
Arizona Cancer Center, Tucson
University of New Mexico Cancer Research and Treatment Center, Albuquerque
Cedars-Sinai Medical Center, Los Angeles
Southern California Permanente Medical Group, Downey
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego
Loma Linda University Medical Center, Loma Linda
Chao Family Comprehensive Cancer Center, Orange
Children's Hospital of Orange County, Orange
Santa Barbara Cottage Hospital, Santa Barbara
Kaiser Permanente Medical Center - San Francisco Geary Campus, San Francisco
Lucile Packard Children's Hospital at Stanford, Palo Alto
David Grant Medical Center, Travis Air Force Base
Sutter Cancer Center, Sacramento
University of California Davis Medical Center, Sacramento
Cancer Research Center of Hawaii, Honolulu
MBCCOP - Hawaii, Honolulu
Legacy Emanuel Hospital and Health Center, Portland
Children's Hospital and Regional Medical Center - Seattle, Seattle
Group Health Cooperative, Seattle
Phoenix Children's Hospital, Phoenix
City of Hope Comprehensive Cancer Center, Duarte
Rebecca and John Moores UCSD Cancer Center, La Jolla
Jonathan Jaques Children's Cancer Center, Long Beach
Children's Hospital Los Angeles, Los Angeles
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles
Children's Hospital Central California, Madera
Children's Hospital of Oakland, Oakland
Children's Hospital San Diego, San Diego
UCSF Comprehensive Cancer Center, San Francisco
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Children's Hospital of Denver, Denver
University of Connecticut Health Center, Farmington
Yale Comprehensive Cancer Center, New Haven
Children's National Medical Center, Washington D.C.
Walter Reed Army Medical Center, Washington D.C.
Shands Hospital and Clinics, University of Florida, Gainesville
Miami Children's Hospital, Miami
Baptist Hospital of Miami, Miami
Tampa Children's Hospital, Tampa
Medical College of Georgia Comprehensive Cancer Center, Augusta
Memorial Health University Medical Center, Inc., Savannah
Tripler Army Medical Center, Honolulu
Lutheran General Hospital, Park Ridge
Southern Illinois University School of Medicine, Springfield
Indiana University Cancer Center, Indianapolis
Holden Comprehensive Cancer Center, Iowa City
Albert B. Chandler Medical Center, University of Kentucky, Lexington
Kosair Children's Hospital, Louisville
Eastern Maine Medical Center, Bangor
Maine Children's Cancer Program, Scarborough
Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Floating Hospital for Children, Boston
Dana-Farber Cancer Institute, Boston
Baystate Medical Center, Springfield
University of Massachusetts Memorial Medical Center - University Campus, Worcester
Mott Children's Hospital, Ann Arbor
CCOP - Beaumont, Royal Oak
William Beaumont Hospital, Royal Oak
St. Mary's/Duluth Clinic Cancer Center, Duluth
University of Mississippi Medical Center, Jackson
University of Nebraska Medical Center, Omaha
Sunrise Hospital and Medical Center, Las Vegas
Norris Cotton Cancer Center, Lebanon
Hackensack University Medical Center, Hackensack
Cancer Institute of New Jersey, New Brunswick
Newark Beth Israel Medical Center, Newark
St. Joseph's Hospital and Medical Center, Paterson
Atlantic Health System, Summit
Roswell Park Cancer Institute, Buffalo
New York Presbyterian Hospital - Cornell Campus, New York
State University of New York Health Sciences Center - Stony Brook, Stony Brook
Lineberger Comprehensive Cancer Center, UNC, Chapel Hill
Carolinas Medical Center, Charlotte
Presbyterian Healthcare, Charlotte
East Carolina University School of Medicine, Greenville
Comprehensive Cancer Center at Wake Forest University, Winston-Salem
Dakota Cancer Institute, Fargo
Children's Hospital Medical Center - Cincinnati, Cincinnati
Ireland Cancer Center, Cleveland
Children's Hospital of Columbus, Columbus
Doernbecher Children's Hospital, Portland
Geisinger Medical Center, Danville
Milton S. Hershey Medical Center, Hershey
St. Christopher's Hospital for Children, Philadelphia
Rhode Island Hospital, Providence
Medical University of South Carolina, Charleston
Avera Cancer Institute, Sioux Falls
Saint Jude Children's Research Hospital, Memphis
Vanderbilt-Ingram Cancer Center, Nashville
Simmons Cancer Center - Dallas, Dallas
University of Texas Medical Branch, Galveston
University of Texas - MD Anderson Cancer Center, Houston
San Antonio Military Pediatric Cancer and Blood Disorders Center, Lackland Air Force Base
Methodist Health Care System, San Antonio
Vermont Cancer Center, Burlington
Inova Fairfax Hospital, Falls Church
Naval Medical Center, Portsmouth, Portsmouth
Massey Cancer Center, Richmond
Fred Hutchinson Cancer Research Center, Seattle
Deaconess Medical Center, Spokane
Mary Bridge Children's Health Center, Tacoma
Madigan Army Medical Center, Tacoma
West Virginia University Hospitals, Morgantown
St. Vincent Hospital, Green Bay
University of Wisconsin Hospital and Clinics, Madison
Marshfield Clinic, Marshfield
Alberta Children's Hospital, Calgary
Cross Cancer Institute, Edmonton
British Columbia Children's Hospital, Vancouver
CancerCare Manitoba, Winnipeg
Janeway Children's Health and Rehabilitation Centre, St. John's
IWK Health Centre, Halifax
Children's Hospital, Hamilton
Children's Hospital of Western Ontario, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
McGill University Health Center - Montreal Children's Hospital, Montreal
Hopital Sainte Justine, Montreal
Laval University Medical Center, Sainte-Foy
Centre Hospitalier de L'Universite Laval, Sainte-Foy
Allan Blair Cancer Centre, Regina
Saskatoon Cancer Centre, Saskatoon
Academisch Ziekenhuis Groningen, Groningen
Starship Children's Hospital, Auckland
University of Puerto Rico School of Medicine Medical Sciences Campus, San Juan
San Jorge Childrens Hospital, Santurce
Swiss Pediatric Oncology Group Bern, Bern
Swiss Pediatric Oncology Group Geneva, Geneva
Swiss Pediatric Oncology Group Lausanne, Lausanne
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK