52
Participants
Start Date
June 30, 1994
Primary Completion Date
November 30, 2003
Study Completion Date
July 31, 2011
bleomycin sulfate
5u/m2 IV Q21days x 6 cycles
filgrastim
5ug/kg SC, Days 9-20, Q 21 days x 6 cycles
cyclophosphamide
490 mg/m2 IV Q 21 days x 6 cycles
cytarabine
225 mg/m2 IV Q 21 days x 6 cycles
doxorubicin hydrochloride
19 mg/m2 IV Q 21 days x 6 cycles
etoposide
90 mg/m2 IV Q 21 days x 6 cycles
leucovorin calcium
25 mg/m2 po 24 hours after methotrexate Q 6 hours x 4 doses for 6 cycles.
methotrexate
90 mg/m2 IV, Q 21 days x 6 cycles.
prednisone
60 mg/m2 po QD x 14days for 6 cycles
trimethoprim-sulfamethoxazole
1 double throughout strength treatment tablet po on Monday, Wednesday, and Friday x 6, 21 day cycles
vincristine sulfate
1.4 mg/m2 IV Q 21 Days x 6 cycles
radiation therapy
All patients achieving a CR or PR following systemic therapy and IT Ara-C, will receive 2,400 cGy in two hundred cGy fractions to the whole brain. Fields should adequately encompass all meningeal surfaces.
Intrathecal cytarabine
"If initial bone marrow positive:~Ara-C 30 mg/m2 IT per dose x 5 doses spaced evenly during the first two cycles of therapy. Ara-C 30 mg/m2 IT Day 1 of each subsequent cycle.~If initial CSF cytology positive:~Ara-C 30 mg/m2 IT per dose x 5 doses spaced evenly during the first cycle of therapy. If CSF negative after above, Ara-C 30 mg/m2 IT Day 1 of each subsequent cycle. If CSF positive after initial five doses of Ara-C, IT MTX 12 mg per dose x 5 doses should be given spaced evenly during the second cycle of therapy.~If initial bone marrow and CSF negative:~Ara-C 30 mg/m2 IT per dose x 5 doses to be given spaced evenly within 1 month of completion of systemic therapy."
Herbert Irving Comprehensive Cancer Center, New York
CCOP - Upstate Carolina, Spartanburg
CCOP - Greenville, Greenville
MBCCOP - University of South Alabama, Mobile
Veterans Affairs Medical Center - Jackson, Jackson
CCOP - Columbus, Columbus
Cleveland Clinic Cancer Center, Cleveland
Barrett Cancer Center, The University Hospital, Cincinnati
Veterans Affairs Medical Center - Dayton, Dayton
CCOP - Dayton, Kettering
Veterans Affairs Medical Center - Ann Arbor, Ann Arbor
Barbara Ann Karmanos Cancer Institute, Detroit
Henry Ford Hospital, Detroit
CCOP - Grand Rapids Clinical Oncology Program, Grand Rapids
CCOP - Montana Cancer Consortium, Billings
Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital), Hines
Loyola University Medical Center, Maywood
CCOP - Central Illinois, Decatur
CCOP - St. Louis-Cape Girardeau, St Louis
Veterans Affairs Medical Center - Kansas City, Kansas City
CCOP - Kansas City, Kansas City
CCOP - Cancer Research for the Ozarks, Springfield
Veterans Affairs Medical Center - Wichita, Wichita
MBCCOP - LSU Medical Center, New Orleans
Tulane University School of Medicine, New Orleans
Veterans Affairs Medical Center - New Orleans, New Orleans
Veterans Affairs Medical Center - Shreveport, Shreveport
University of Arkansas for Medical Sciences, Little Rock
Veterans Affairs Medical Center - Little Rock (McClellan), Little Rock
Oklahoma Medical Research Foundation, Oklahoma City
Veterans Affairs Medical Center - Oklahoma City, Oklahoma City
Veterans Affairs Medical Center - Temple, Temple
CCOP - Scott and White Hospital, Temple
Brooke Army Medical Center, Fort Sam Houston
Veterans Affairs Medical Center - San Antonio (Murphy), San Antonio
Texas Tech University Health Science Center, Lubbock
Veterans Affairs Medical Center - Denver, Denver
University of Colorado Cancer Center, Denver
Huntsman Cancer Institute, Salt Lake City
Veterans Affairs Medical Center - Salt Lake City, Salt Lake City
Veterans Affairs Medical Center - Phoenix (Hayden), Phoenix
Veterans Affairs Medical Center - Tucson, Tucson
Arizona Cancer Center, Tucson
MBCCOP - University of New Mexico HSC, Albuquerque
Veterans Affairs Medical Center - Long Beach, Long Beach
Beckman Research Institute, City of Hope, Los Angeles
Chao Family Comprehensive Cancer Center, Orange
David Grant Medical Center, Travis Air Force Base
Veterans Affairs Outpatient Clinic - Martinez, Martinez
CCOP - Santa Rosa Memorial Hospital, Santa Rosa
University of California Davis Medical Center, Sacramento
Cancer Research Center of Hawaii, Honolulu
Veterans Affairs Medical Center - Portland, Portland
CCOP - Columbia River Program, Portland
CCOP - Virginia Mason Research Center, Seattle
Swedish Cancer Institute, Seattle
Veterans Affairs Medical Center - Seattle, Seattle
Puget Sound Oncology Consortium, Seattle
CCOP - Greater Phoenix, Phoenix
USC/Norris Comprehensive Cancer Center, Los Angeles
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles
CCOP - Bay Area Tumor Institute, Oakland
CCOP - Atlanta Regional, Atlanta
Tripler Army Medical Center, Honolulu
University of Kansas Medical Center, Kansas City
CCOP - Wichita, Wichita
Veterans Affairs Medical Center - Lexington, Lexington
Albert B. Chandler Medical Center, University of Kentucky, Lexington
Louisiana State University Health Sciences Center - Shreveport, Shreveport
Boston Medical Center, Boston
Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain
University of Michigan Comprehensive Cancer Center, Ann Arbor
Veterans Affairs Medical Center - Detroit, Detroit
Providence Hospital - Southfield, Southfield
Veterans Affairs Medical Center - Biloxi, Biloxi
University of Mississippi Medical Center, Jackson
Keesler Medical Center - Keesler AFB, Keesler Air Force Base
St. Louis University Health Sciences Center, St Louis
Veterans Affairs Medical Center - Albuquerque, Albuquerque
Veterans Affairs Medical Center - Cincinnati, Cincinnati
Oregon Cancer Center at Oregon Health Sciences University, Portland
Simmons Cancer Center - Dallas, Dallas
University of Texas Medical Branch, Galveston
University of Texas Health Science Center at San Antonio, San Antonio
CCOP - Northwest, Tacoma
National Cancer Institute (NCI)
NIH
SWOG Cancer Research Network
NETWORK