899
Participants
Start Date
January 31, 1994
Primary Completion Date
October 31, 2003
Study Completion Date
November 30, 2006
recombinant interferon alfa
"3 million units/m2 SQ Monday-Wednesday~-Friday (3 times a week)"
carmustine
20 mg/m2 I.V. day 1 q 35 days
cyclophosphamide
1.5 g/m2 in 100 ml of D5W, IV intravenously over 1 hour every 3 hour x 3 (total dose 4.5 g/m2)
dexamethasone
40 mg/day PO or IVPB days 1-4, 9-12, 17-20 q 5 weeks
doxorubicin hydrochloride
10 mg/m2/day continuous 1 - 4 q 5 weeks
melphalan
140 mg/m2 is given IV within 30 minutes of constitution on Day -5
prednisone
40 mg/m2 PO days 1-7 q 35 days
vincristine sulfate
0.5 mg/day continuous 1 - 4 q 5 weeks
allogeneic bone marrow transplantation
day 0
autologous bone marrow transplantation
day 0
peripheral blood stem cell transplantation
day 0
radiation therapy
administered in fractionated doses of 150 cGy, 6 - 10 hours apart bid, on Days -4, -3, -2, and -1 (Total 1,200 cGy)
Veterans Affairs Medical Center - New York, New York
NYU School of Medicine's Kaplan Comprehensive Cancer Center, New York
Albert Einstein Comprehensive Cancer Center, The Bronx
University of Rochester Cancer Center, Rochester
Fox Chase Cancer Center, Philadelphia
Veterans Affairs Medical Center - Indianapolis (Roudebush), Indianapolis
CCOP - Ann Arbor Regional, Ann Arbor
Medical College of Wisconsin, Milwaukee
Veterans Affairs Medical Center - Milwaukee (Zablocki), Milwaukee
CCOP - Marshfield Medical Research and Education Foundation, Marshfield
CCOP - Metro-Minnesota, Saint Louis Park
University of Minnesota Cancer Center, Minneapolis
CCOP - Duluth, Duluth
Mayo Clinic Cancer Center, Rochester
CCOP - Evanston, Evanston
Veterans Affairs Medical Center - Lakeside Chicago, Chicago
CCOP - Illinois Oncology Research Association, Peoria
CCOP - Carle Cancer Center, Urbana
CCOP - Ochsner, New Orleans
CCOP - Scottsdale Oncology Program, Scottsdale
CCOP - Colorado Cancer Research Program, Inc., Denver
H. Lee Moffitt Cancer Center and Research Institute, Tampa
Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago
Indiana University Cancer Center, Indianapolis
CCOP - Iowa Oncology Research Association, Des Moines
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
New England Medical Center Hospital, Boston
Beth Israel Deaconess Medical Center, Boston
CCOP - Kalamazoo, Kalamazoo
Ireland Cancer Center, Cleveland
CCOP - Toledo Community Hospital Oncology Program, Toledo
CCOP - Geisinger Clinic and Medical Center, Danville
Hahnemann University Hospital, Philadelphia
University of Pittsburgh Cancer Institute, Pittsburgh
National Cancer Institute (NCI)
NIH
Cancer and Leukemia Group B
NETWORK
Eastern Cooperative Oncology Group
NETWORK
SWOG Cancer Research Network
NETWORK