Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

PHASE3CompletedINTERVENTIONAL
Enrollment

364

Participants

Timeline

Start Date

Not specified

Study Completion Date

September 30, 1991

Conditions
Pneumonia, Pneumocystis CariniiHIV Infections
Interventions
DRUG

Trimetrexate glucuronate

DRUG

Pentamidine isethionate

DRUG

Sulfamethoxazole-Trimethoprim

DRUG

Leucovorin calcium

Trial Locations (23)

10003

Beth Israel Med Ctr / Peter Krueger Clinic, New York

10029

Mount Sinai Med Ctr, New York

10461

Bronx Municipal Hosp Ctr/Jacobi Med Ctr, The Bronx

10465

Jack Weiler Hosp / Bronx Municipal Hosp, The Bronx

10467

Montefiore Med Ctr / Bronx Municipal Hosp, The Bronx

11373

City Hosp Ctr at Elmhurst / Mount Sinai Hosp, Elmhurst

13210

SUNY / State Univ of New York, Syracuse

14215

SUNY / Erie County Med Ctr at Buffalo, Buffalo

14642

Univ of Rochester Medical Center, Rochester

19107

Thomas Jefferson Med College, Philadelphia

20037

George Washington Univ Med Ctr, Washington D.C.

29169

Julio Arroyo, West Columbia

44106

Univ Hosp of Cleveland / Case Western Reserve Univ, Cleveland

60611

Northwestern Univ Med School, Chicago

70112

Charity Hosp / Tulane Univ Med School, New Orleans

Louisiana State Univ Med Ctr / Tulane Med School, New Orleans

Tulane Univ School of Medicine, New Orleans

90033

Los Angeles County - USC Med Ctr, Los Angeles

117948153

SUNY - Stony Brook, Stony Brook

170330850

Milton S Hershey Med Ctr, Hershey

331361013

Univ of Miami School of Medicine, Miami

452670405

Holmes Hosp / Univ of Cincinnati Med Ctr, Cincinnati

01655

Univ of Massachusetts Med Ctr, Worcester

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH