A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection

PHASE2CompletedINTERVENTIONAL
Enrollment

240

Participants

Timeline

Start Date

Not specified

Study Completion Date

October 31, 1997

Conditions
HIV InfectionsPeripheral Nervous System Disease
Interventions
DRUG

Mexiletine hydrochloride

DRUG

Benztropine mesylate

DRUG

Amitriptyline hydrochloride

Trial Locations (37)

13210

SUNY - Buffalo, Erie County Medical Ctr., Buffalo

14642

Univ. of Rochester ACTG CRS, Rochester

19104

Hosp. of the Univ. of Pennsylvania CRS, Philadelphia

20059

Howard University Hosp., Div. of Infectious Diseases, ACTU, Washington D.C.

21287

Johns Hopkins Adult AIDS CRS, Baltimore

35294

Alabama Therapeutics CRS, Birmingham

44106

Case CRS, Cleveland

46202

Methodist Hosp. of Indiana, Indianapolis

52242

Univ. of Iowa Healthcare, Div. of Infectious Diseases, Iowa City

55415

Hennepin County Med. Ctr., Div. of Infectious Diseases, Minneapolis

55455

University of Minnesota, ACTU, Minneapolis

60611

Northwestern University CRS, Chicago

60612

Cook County Hosp. CORE Ctr., Chicago

Rush Univ. Med. Ctr. ACTG CRS, Chicago

60640

Weiss Memorial Hosp., Chicago

63112

St. Louis ConnectCare, Infectious Diseases Clinic, St Louis

80262

University of Colorado Hospital CRS, Aurora

90095

UCLA CARE Center CRS, Los Angeles

90502

Harbor-UCLA Med. Ctr. CRS, Torrance

96816

Queens Med. Ctr., Honolulu

Univ. of Hawaii at Manoa, Leahi Hosp., Honolulu

98104

University of Washington AIDS CRS, Seattle

275997215

Unc Aids Crs, Chapel Hill

331361013

Univ. of Miami AIDS CRS, Miami

452670405

Univ. of Cincinnati CRS, Cincinnati

462025250

Indiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis

681985130

Univ. of Nebraska Med. Ctr., Durham Outpatient Ctr., Omaha

921036325

Ucsd, Avrc Crs, San Diego

Unknown

Ucsf Aids Crs, San Francisco

The Ponce de Leon Ctr. CRS, Atlanta

Tulane Med. Ctr. - Charity Hosp. of New Orleans, ACTU, New Orleans

Beth Israel Deaconess - East Campus A0102 CRS, Boston

Washington U CRS, St Louis

Mbeya Med. Research Program, Mbeya Referral Hosp. CRS, Mbeya

02114

Massachusetts General Hospital ACTG CRS, Boston

02118

Bmc Actg Crs, Boston

02215

Beth Israel Deaconess Med. Ctr., ACTG CRS, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Boehringer Ingelheim

INDUSTRY

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT00000793 - A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection | Biotech Hunter | Biotech Hunter