A Randomized, Double-Blind, Four-Arm Study Comparing Combination Nucleoside, Alternating Nucleoside, and Triple-Drug Therapy for the Treatment of Advanced HIV Disease (CD4 <= 50/mm3)

PHASE2CompletedINTERVENTIONAL
Enrollment

1,292

Participants

Timeline

Start Date

Not specified

Study Completion Date

September 30, 1996

Conditions
HIV Infections
Interventions
DRUG

Nevirapine

DRUG

Zidovudine

DRUG

Zalcitabine

DRUG

Didanosine

Trial Locations (96)

10003

Beth Israel Med Ctr, New York

10016

Bellevue Hosp / New York Univ Med Ctr, New York

10019

Saint Clare's Hosp and Health Ctr, New York

10021

Cornell Univ Med Ctr, New York

Mem Sloan - Kettering Cancer Ctr, New York

10029

Mount Sinai Med Ctr / Hemophilia Treatment Ctr, New York

Mount Sinai Med Ctr, New York

10037

Harlem Hosp Ctr, New York

10461

Bronx Municipal Hosp Ctr/Jacobi Med Ctr, The Bronx

Comprehensive Health Care Ctr / Bronx Municipal Hosp, The Bronx

Montefiore Drug Treatment Ctr / Bronx Municipal Hosp, The Bronx

Montefiore Family Health Ctr / Bronx Municipal Hosp, The Bronx

Samaritan Village Inc / Bronx Municipal Hosp, The Bronx

10465

Jack Weiler Hosp / Bronx Municipal Hosp, The Bronx

10467

Montefiore Med Ctr / Bronx Municipal Hosp, The Bronx

Montefiore Med Ctr Adolescent AIDS Program, The Bronx

North Central Bronx Hosp / Bronx Municipal Hosp, The Bronx

10468

Bronx Veterans Administration / Mount Sinai Hosp, The Bronx

11030

North Shore Univ Hosp, Manhasset

11373

City Hosp Ctr at Elmhurst / Mount Sinai Hosp, Elmhurst

13210

SUNY / State Univ of New York, Syracuse

14215

SUNY / Erie County Med Ctr at Buffalo, Buffalo

14642

Univ of Rochester Medical Center, Rochester

19104

Univ of Pennsylvania at Philadelphia, Philadelphia

20007

Georgetown Univ Med Ctr, Washington D.C.

20037

George Washington Univ / Hershey Med Ctr, Washington D.C.

20059

Howard Univ, Washington D.C.

27401

Moses H Cone Memorial Hosp, Greensboro

29169

Julio Arroyo, West Columbia

29425

Med Univ of South Carolina / UNC, Charleston

33612

Univ of South Florida, Tampa

35294

Univ of Alabama at Birmingham, Birmingham

37203

Meharry Med College, Nashville

37920

Univ of Tennessee / E Tennessee Comprehensive Hemophilia Ctr, Knoxville

40202

Univ of Louisville / East Tennesee Comprehensive Hem Ctr, Louisville

43699

Med College of Ohio, Toledo

44106

Case Western Reserve Univ, Cleveland

45267

Univ of Kentucky Lexington, Cincinnati

46202

Methodist Hosp of Indiana / Life Care Clinic, Indianapolis

54301

Northern Wisconsin Hemophilia Ctr / Saint Vincent's Hosp, Green Bay

55101

St Paul Ramsey Med Ctr, Saint Paul

55415

Hennepin County Med Clinic, Minneapolis

55455

Univ of Minnesota, Minneapolis

60611

Northwestern Univ Med School, Chicago

60612

Cook County Hosp, Chicago

Rush Presbyterian - Saint Luke's Med Ctr, Chicago

60640

Louis A Weiss Memorial Hosp, Chicago

63112

St Louis Regional Hosp / St Louis Regional Med Ctr, St Louis

77030

Univ Texas Health Science Ctr / Univ Texas Med School, Houston

80262

Denver Dept of Health and Hosps, Denver

Mountain States Reg Hemo Ctr / Univ of Colorado, Denver

Rose Med Ctr, Denver

Univ of Colorado Health Sciences Ctr, Denver

90027

Children's Hosp of Los Angeles, Los Angeles

90502

Harbor UCLA Med Ctr, Torrance

91105

Huntington Memorial Hosp / Children's Hosp of Los Angeles, Pasadena

91342

Olive View Med Ctr, Sylmar

94115

Stanford at Kaiser / Kaiser Permanente Med Ctr, San Francisco

96816

Univ of Hawaii, Honolulu

100323784

Columbia Presbyterian Med Ctr, New York

112032098

SUNY / Health Sciences Ctr at Brooklyn, Brooklyn

122083479

Adirondack Med Ctr at Saranac Lake, Albany

Albany Med College / Division of HIV Medicine A158, Albany

Mid - Hudson Care Ctr, Albany

170330850

Milton S Hershey Med Ctr, Hershey

Saint Michael's Med Ctr / Milton S Hershey Med Ctr, Hershey

191046073

Girard Med Ctr, Philadelphia

191075098

Thomas Jefferson Univ Hosp, Philadelphia

200072197

HIV Ctr - District of Columbia Gen Hosp, Washington D.C.

Whitman - Walker Clinic / Georgetown Univ Med Ctr, Washington D.C.

275997215

Univ of North Carolina, Chapel Hill

331361013

Univ of Miami School of Medicine, Miami

432052696

Columbus Children's Hosp, Columbus

441091998

MetroHealth Med Ctr, Cleveland

452670405

Univ of Cincinnati, Cincinnati

462025250

Indiana Univ Hosp, Indianapolis

532130127

Great Lakes Hemophilia Foundation, Wauwatosa

681985130

Univ of Nebraska Med Ctr, Omaha

775550435

Univ of Texas Galveston, Galveston

900331079

Univ of Southern California / LA County USC Med Ctr, Los Angeles

921036325

Univ of California / San Diego Treatment Ctr, San Diego

941102859

San Francisco AIDS Clinic / San Francisco Gen Hosp, San Francisco

San Francisco Gen Hosp, San Francisco

943055107

San Mateo AIDS Program / Stanford Univ, Stanford

Stanford Univ Med Ctr, Stanford

951282699

Santa Clara Valley Med Ctr / AIDS Community Rsch Consortium, San Jose

981224304

Univ of Washington, Seattle

065102483

Yale Univ / New Haven, New Haven

02114

Harvard (Massachusetts Gen Hosp), Boston

02118

Boston Med Ctr, Boston

02215

Beth Israel Deaconess - West Campus, Boston

01605

Worcester Memorial Hosp / Med Ctr of Cntrl MA-Memorial, Worcester

03756

Dartmouth - Hitchcock Med Ctr / Med Ctr Cntrl Massachusetts, Lebanon

08903

Robert Wood Johnson Med School / Hershey Med Ctr, New Brunswick

071032714

Univ of Medicine & Dentistry of New Jersey / Univ Hosp, Newark

009365067

Univ of Puerto Rico, San Juan

Sponsors
All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Glaxo Wellcome

INDUSTRY

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH