A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis

NACompletedINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

Not specified

Study Completion Date

September 30, 1997

Conditions
Meningitis, CryptococcalHIV Infections
Interventions
DRUG

Itraconazole

DRUG

Flucytosine

DRUG

Fluconazole

DRUG

Amphotericin B

Trial Locations (24)

10003

Beth Israel Med. Ctr. (Mt. Sinai), New York

10021

Cornell University A2201, New York

14215

SUNY - Buffalo, Erie County Medical Ctr., Buffalo

14642

Univ. of Rochester ACTG CRS, Rochester

15213

Pitt CRS, Pittsburgh

19104

Hosp. of the Univ. of Pennsylvania CRS, Philadelphia

27401

Regional Center for Infectious Disease, Wendover Medical Center CRS, Greensboro

27599

Unc Aids Crs, Chapel Hill

33136

Univ. of Miami AIDS CRS, Miami

43210

The Ohio State Univ. AIDS CRS, Columbus

45267

Univ. of Cincinnati CRS, Cincinnati

46202

Indiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis

Methodist Hosp. of Indiana, Indianapolis

60611

Northwestern University CRS, Chicago

70112

Tulane Med. Ctr. - Charity Hosp. of New Orleans, ACTU, New Orleans

90033

USC CRS, Los Angeles

94110

Ucsf Aids Crs, San Francisco

Unknown

Univ. of Hawaii at Manoa, Leahi Hosp., Honolulu

St. Louis ConnectCare, Infectious Diseases Clinic, St Louis

Washington U CRS, St Louis

Carolinas HealthCare System, Carolinas Med. Ctr., Charlotte

02114

Massachusetts General Hospital ACTG CRS, Boston

02118

Bmc Actg Crs, Boston

02215

Beth Israel Deaconess Med. Ctr., ACTG CRS, Boston

All Listed Sponsors
collaborator

Washington University School of Medicine

OTHER

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT00000639 - A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis | Biotech Hunter | Biotech Hunter