Small Molecules
Total Trials
80
As Lead Sponsor
77
As Collaborator
3
Total Enrollment
22,315
NCT00490945
Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers
Phase: Phase 2
Role: Lead Sponsor
Start: Jul 31, 2004
Completion: Mar 31, 2005
NCT00254202
Efficacy and Safety of Iloperidone Compared With Placebo and Active Control in Subjects With Acute Schizophrenia
Phase: Phase 3
Start: Nov 18, 2005
Completion: Mar 21, 2007
NCT00291187
VEC-162 Study in Healthy Adult Volunteers in a Model of Insomnia
Start: Feb 28, 2006
Completion: Aug 31, 2006
NCT00548340
VEC-162 Study in Adult Patients With Primary Insomnia
Start: Nov 30, 2007
Completion: Jun 30, 2008
NCT01195558
Patient Registry of Blind Subjects With Sleep-related Problems
Phase: N/A
Start: Apr 30, 2010
Completion: Apr 30, 2030
NCT01163032
Efficacy and Safety of Tasimelteon Compared With Placebo in Totally Blind Subjects With Non-24-Hour Sleep-Wake Disorder
Start: Aug 31, 2010
Completion: Nov 30, 2012
NCT01218789
Safety Study of Tasimelteon for Treatment of Non-24-Hour-Sleep-Wake Disorder in Blind Individuals With No Light Perception
Start: Oct 28, 2010
Completion: Dec 5, 2024
NCT01271387
Pharmacokinetics of Tasimelteon in Subjects With Mild or Moderate Hepatic Impairment
Phase: Phase 1
Start: Jan 31, 2011
Completion: Aug 31, 2011
NCT01291511
Relapse Prevention Study in Patients With Schizophrenia
Start: Feb 28, 2011
Completion: Mar 31, 2015
NCT01348100
Safety, Tolerability, and Pharmacokinetics of Iloperidone Depot in Schizophrenic Patients
Phase: Phase 1/2
Role: Collaborator
Start: Apr 30, 2011
Completion: Jul 31, 2012
NCT01402076
A Study to Assess the Effect Tasimelteon on the Cytochrome P450 3A4 and 2C8 Enzymes in Healthy Subjects
Start: Aug 31, 2011
NCT01428661
Melatonin Agonist Effects of Tasimelteon Versus Placebo in Patients With Major Depressive Disorder
Phase: Phase 2/3
Start: Sep 30, 2011
Completion: May 31, 2013
NCT01430754
Withdrawal Study to Demonstrate the Maintenance Effect in the Treatment of Non-24-Hour Sleep-Wake Disorder
Completion: Dec 31, 2012
NCT01429116
Tasimelteon for the Treatment of Non-24-hour Sleep-Wake Disorder (N24HSWD) in Blind Individuals With no Light Perception
Start: Oct 31, 2011
Completion: Jan 31, 2015
NCT01495169
Tolerability and Pharmacokinetics of Iloperidone in Adolescent Patients
Completion: Feb 28, 2015
NCT01477619
Effects of Smoking, Age and Body Size on Pharmacokinetics, Safety and Tolerability on Tasimelteon in Healthy Subjects
Start: Nov 30, 2011
Completion: Jan 31, 2012
NCT01526746
Pharmacokinetics of Tasimelteon in Subjects With Renal Impairment and Matched Control Subjects With Relatively Normal Renal Function
Start: Feb 29, 2012
Completion: Jun 30, 2012
NCT01540500
Pharmacokinetics of Tasimelteon Alone and in Combination With CYP1A2 Inhibitor, Fluvoxamine
Completion: Mar 31, 2012
NCT01578057
Evaluation of the Pharmacodynamic and Pharmacokinetic Interactions of Tasimelteon and Ethanol
Start: Apr 30, 2012
NCT02413918
Iloperidone in Mixed States of Bipolar Disorder
Phase: Phase 4
Completion: Apr 30, 2015
NCT01637636
Pharmacokinetics of Tasimelteon Alone and in Combination With a CYP3A4 Inhibitor, Ketoconazole, or a CYP3A4 Inducer, Rifampin.
Start: Jun 30, 2012
Completion: Aug 31, 2012
NCT01919944
Study of Itch Control by VLY-686 in Healthy Volunteers After Intradermal Injections of Substance P
Start: Aug 31, 2013
Completion: Nov 30, 2013
NCT02004041
Proof of Concept of VLY-686 in Subjects With Treatment-Resistant Pruritus Associated With Atopic Dermatitis
Start: Dec 10, 2013
Completion: Feb 19, 2015
NCT02130999
Open Label Study to Assess the Absolute Bioavailability of Tasimelteon (HETLIOZ™)
Start: May 31, 2014
Completion: May 31, 2014
NCT02180451
Observational Study to Investigate the Melatonin and Cortisol Circadian Rhythms of Individuals With Smith-Magenis Syndrome (SMS)
Start: Jun 30, 2014
Completion: Jan 31, 2017
NCT02231008
Evaluating the Effects of Tasimelteon vs Placebo on Sleep Disturbances in SMS
Start: Sep 30, 2015
Completion: Jan 31, 2022
NCT02560103
An Observational Study to Investigate the Effects of Rapid Transmeridian Travel
Completion: Oct 31, 2017
NCT02621385
Study to Assess the Effect of Multiple Doses of Tradipitant on CYP3A4 Using Midazolam as a Substrate in Healthy Subjects
Start: Nov 30, 2015
Completion: Not specified
NCT02651714
Tradipitant in Treatment-resistant Pruritus Associated With Atopic Dermatitis
Start: Jan 19, 2016
Completion: Aug 4, 2017
NCT03154697
Development of Clinical Database of Individuals With Smith-Magenis Syndrome and Sleep Disturbances
Start: Jan 31, 2016
Completion: Dec 31, 2030
NCT03291041
A Proof of Concept Study to Evaluate the Effects of Tasimelteon and Placebo in Travelers With Jet Lag Disorder
Start: Jul 31, 2016
Completion: Nov 30, 2017
NCT02776215
Study of the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents
Start: Oct 4, 2016
Completion: Dec 20, 2017
NCT02970968
Study to Assess the Efficacy of VLY-686 in Relieving Symptoms of Gastroparesis
Start: Nov 30, 2016
Completion: Dec 31, 2018
NCT03373201
Evaluating the Effects of Tasimelteon vs. Placebo on Jet Lag Type Insomnia
Start: Oct 16, 2017
Completion: Mar 5, 2018
NCT03568331
Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE)
Start: Jul 9, 2018
Completion: Dec 27, 2019
NCT06323655
Evaluation of Next-Day Residual Effects of Tasimelteon Compared With Placebo and Active Control in Healthy Subjects
Start: Jul 19, 2018
Completion: Aug 28, 2018
NCT03838926
Tolerability Study of Trichostatin A In Subjects With Relapsed or Refractory Hematologic Malignancies
Start: Sep 27, 2018
Completion: Dec 31, 2025
NCT03772340
Motion Sifnos: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness
Start: Dec 20, 2018
Completion: Jun 27, 2019
NCT03619902
A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in Adults With Generalized Pustular Psoriasis
Start: Jan 30, 2019
Completion: Jan 20, 2021
NCT03633396
A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in Adults With Palmoplantar Pustulosis
Start: May 20, 2019
Completion: Apr 23, 2021
NCT04028492
Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis
Start: Aug 20, 2019
Completion: Feb 21, 2025
NCT04127058
Evaluating a New Iloperidone Titration Scheme in Bipolar I Disorder or Schizophrenia
Start: Oct 7, 2019
Completion: Nov 27, 2019
NCT04140695
Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE2)
Start: Oct 21, 2019
Completion: Oct 14, 2020
NCT04326426
ODYSSEY: A Study to Investigate the Efficacy of Tradipitant in Treating Severe or Critical COVID-19 Infection
Start: Apr 13, 2020
Completion: Aug 31, 2020
NCT04353401
WGS Analysis of COVID-19 Positive Patients
Start: Aug 3, 2020
Completion: Mar 9, 2022
NCT04622345
Safety and Efficacy of VSJ-110 in the Treatment of Allergic Conjunctivitis in Adults With a History of Ocular Allergies
Start: Nov 21, 2020
Completion: Jun 28, 2021
NCT04652882
Evaluating the Effects of Tasimelteon Vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
Start: Dec 9, 2020
NCT04712734
A Study to Evaluate Iloperidone Long-acting Injection (LAI) for the Treatment of Schizophrenia
Start: Jan 13, 2021
Completion: Aug 30, 2022
NCT04697056
A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Ichthyosis
Start: Jan 25, 2021
Completion: Nov 19, 2021
NCT04849559
Effects of Tradipitant on Satiation, Gastric Volume, Gastric Accommodation, and Gastric Emptying in Healthy Volunteers
Start: Feb 1, 2021
Completion: Sep 24, 2021
NCT04800237
Evaluating the Effects of VQW-765 vs. Placebo in Performance Anxiety
Start: Feb 23, 2021
Completion: Aug 2, 2022
NCT04819776
Evaluation of Efficacy and Safety of Iloperidone in the Acute Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder
Start: Mar 22, 2021
Completion: Aug 16, 2023
NCT04697069
A Study to Evaluate of the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Acneiform Rash
Start: May 4, 2021
Completion: Dec 13, 2021
NCT04856917
A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Acne Vulgaris
Start: May 15, 2021
Completion: Mar 29, 2022
NCT04969211
Bioequivalence Study Between VHX-896 Tablets and Iloperidone Tablets in Healthy Volunteers
Start: Jun 30, 2021
Completion: Oct 13, 2021
NCT04856930
A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Hidradenitis Suppurativa
Start: Jul 7, 2021
Completion: Dec 14, 2022
NCT05361707
Evaluating the Effects of Tasimelteon in Individuals With Autism Spectrum Disorder (ASD) and Sleep Disturbances
Start: Jul 28, 2021
Completion: Jul 31, 2025
NCT04327661
Motion Syros: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness
Start: Nov 15, 2021
Completion: Apr 12, 2023
NCT05352893
Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Subjects With GPP
Start: Apr 14, 2022
Completion: Aug 17, 2023
NCT05366855
Long-Term Safety and Efficacy of Imsidolimab (ANB019) in Subjects With Generalized Pustular Psoriasis
Start: Apr 21, 2022
Completion: Jul 17, 2024
NCT05572281
Bioequivalence Study Between Tasimelteon Capsule Formulation and Liquid Suspension Formulation in Healthy Volunteers
Start: May 18, 2022
Completion: Jun 15, 2022
NCT06803290
Food Effect Study of VHX-896 in Healthy Volunteers
Start: Jun 21, 2022
Completion: Dec 27, 2022
NCT05344365
A Study to Evaluate Iloperidone for the Treatment of Parkinson's Disease Psychosis
Start: Jun 30, 2022
Completion: Nov 30, 2023
NCT06138613
Motion Delos: An Open Label Safety and Efficacy of Tradipitant in Participants Affected by Motion Sickness
Start: Feb 27, 2023
Completion: Apr 30, 2025
NCT05648591
Safety and Tolerability of Open-Labeled Iloperidone in Adolescents
Start: May 24, 2023
Completion: Nov 30, 2026
NCT05903924
Motion Serifos: A Study to Investigate the Efficacy of Tradipitant in Participants Affected by Motion Sickness
Start: Sep 9, 2023
Completion: Apr 24, 2024
NCT05922995
The Effects of Tasimelteon in Participants With REM Behavior Disorder (RBD)
Phase: Early Phase 1
Start: Sep 30, 2023
Completion: Dec 1, 2023
NCT06836557
Open Label Safety Study of Tradipitant in Idiopathic and Diabetic Gastroparesis
Start: Jan 9, 2024
NCT06296966
A Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye
Start: Feb 29, 2024
Completion: Jul 31, 2024
NCT06494397
Pharmacokinetic Study of VHX-896 and Iloperidone Tablets Under Steady-State Conditions
Start: Jul 11, 2024
Completion: Oct 24, 2024
NCT06701396
Evaluating the Effects of Tasimelteon Vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD) and the CRY1Δ11 Variant
Start: Oct 8, 2024
Completion: Jun 30, 2025
NCT06804603
A Study to Measure the Effects of Using Tradipitant on Nausea and Vomiting After GLP-1R Agonist Use
Start: Feb 25, 2025
Completion: Sep 1, 2025
NCT06830044
Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
Start: Mar 3, 2025
Completion: Mar 31, 2028
NCT06953869
Evaluating the Effects of Tasimelteon vs. Placebo in Treating Pediatric Insomnia
Start: Apr 21, 2025
Completion: Jan 31, 2028
NCT07065773
Safety, Tolerability and Efficacy of Trichostatin A in Patients With Mild to Severe Onychomycosis
Start: May 5, 2025
Completion: May 31, 2026
NCT06961968
Randomized Withdrawal Study in Patients With Schizophrenia
Start: May 14, 2025
Completion: Nov 30, 2027
NCT07090161
Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
Start: Jul 28, 2025
NCT07179055
An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye
Start: Oct 31, 2025
Completion: Sep 30, 2026
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