Human Reovirus Delivery
Total Trials
21
As Lead Sponsor
13
As Collaborator
8
Total Enrollment
997
NCT00528684
Safety and Efficacy Study of REOLYSIN® in the Treatment of Recurrent Malignant Gliomas
Phase: Phase 1
Role: Lead Sponsor
Start: Jul 31, 2006
Completion: Jun 30, 2010
NCT00503295
Safety and Efficacy Study of REOLYSIN® in the Treatment of Bone and Soft Tissue Sarcomas Metastatic to the Lung
Phase: Phase 2
Start: Jun 30, 2007
Completion: Apr 30, 2011
NCT00753038
Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Patients With Head and Neck Carcinoma
Start: Aug 31, 2008
Completion: May 31, 2013
NCT00861627
Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin for Non-Small Cell Lung Cancer With KRAS or EGFR Activation
Start: Mar 31, 2009
Completion: Nov 30, 2015
NCT00984464
Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Patients With Metastatic Melanoma
Start: Sep 30, 2009
Completion: Oct 31, 2014
NCT00998192
A Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Patients With Squamous Cell Carcinoma of the Lung
Start: Oct 31, 2009
Completion: Aug 31, 2015
NCT00998322
A Study of REOLYSIN® in Combination With Gemcitabine in Patients With Advanced Pancreatic Adenocarcinoma
Completion: Feb 28, 2015
NCT01166542
Efficacy Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Platinum-Refractory Head and Neck Cancers
Phase: Phase 3
Start: Jun 30, 2010
Completion: May 31, 2014
NCT01274624
Study of REOLYSIN® in Combination With FOLFIRI and Bevacizumab in FOLFIRI Naive Patients With KRAS Mutant Metastatic Colorectal Cancer
Start: Dec 31, 2010
Completion: Nov 30, 2018
NCT01622543
Reolysin in Combination With FOLFOX6 and Bevacizumab or FOLFOX6 and Bevacizumab Alone in Metastatic Colorectal Cancer
Role: Collaborator
Start: Oct 26, 2012
Completion: Sep 12, 2018
NCT01708993
Reolysin in Previously Treated Advanced/Metastatic, Non Small Cell Lung Cancer Receiving Standard Salvage Therapy
Start: Dec 10, 2012
Completion: Sep 26, 2018
NCT01619813
Reolysin Combined With Docetaxel and Prednisone or Docetaxel and Prednisone Alone in Metastatic Castration Resistant Prostate Cancer
Start: Dec 14, 2012
Completion: May 20, 2016
NCT01656538
A Study of Reolysin For Patients With Advanced/Metastatic Breast Cancer
Start: Feb 20, 2013
Completion: Feb 14, 2018
NCT02514382
Wild-Type Reovirus, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
Start: Aug 21, 2015
Completion: Apr 19, 2022
NCT02620423
Study of Pembrolizumab With REOLYSIN® and Chemotherapy in Patients With Advanced Pancreatic Adenocarcinoma
Start: Dec 31, 2015
Completion: Aug 31, 2018
NCT02723838
Study of Intratumoral REOLYSIN® in Combination With Gemcitabine and Cisplatin as Neoadjuvant Therapy in Muscle-invasive Transitional Cell Carcinoma of the Bladder
Start: Feb 28, 2017
Completion: Feb 28, 2018
NCT03015922
Viral Immunotherapy in Relapsed/Refractory Multiple Myeloma
Start: Jun 5, 2017
Completion: Oct 1, 2021
NCT03605719
Dexamethasone, Carfilzomib, & Nivolumab With Pelareorep for Relapsed/Refractory Multiple Myeloma
Start: Oct 24, 2018
Completion: Oct 10, 2022
NCT04102618
A Window-of-opportunity Study of Pelareorep in Early Breast Cancer
Phase: Early Phase 1
Start: Mar 29, 2019
Completion: Apr 20, 2022
NCT04215146
A Study to Assess Overall Response Rate by Inducing an Inflammatory Phenotype in Metastatic BReast cAnCEr With the Oncolytic Reovirus PeLareorEp in CombinaTion With Anti-PD-L1 Avelumab and Paclitaxel - BRACELET-1 Study
Start: Jun 10, 2020
Completion: Jun 30, 2025
NCT04445844
INCMGA00012 and Pelareorep for the Treatment of Metastatic Triple Negative Breast Cancer, IRENE Study
Start: Jul 13, 2020
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