Ophthalmology Products
Total Trials
14
As Lead Sponsor
As Collaborator
0
Total Enrollment
879
NCT02193113
A Phase I Single Ascending Dose Study of the Intravitreal Plasma Kallikrein Inhibitor KVD001 in Subjects With DME
Phase: Phase 1
Role: Lead Sponsor
Start: Jul 18, 2014
Completion: Jun 4, 2015
NCT04349800
A Single Dose Safety, Tolerability, Pharmacokinetic and Food Effect Study of KVD900 (Sebetralstat) in Healthy Volunteers
Start: Jan 4, 2018
Completion: Sep 10, 2018
NCT03466099
Study of the Intravitreal Plasma Kallikrein Inhibitor, KVD001, in Subjects With Center-involving Diabetic Macular Edema (ciDME)
Phase: Phase 2
Start: Feb 16, 2018
Completion: Oct 10, 2019
NCT05178355
A Single and Multiple Doses Safety, Tolerability, Pharmacokinetics and Food Effect Study of KVD824 in Healthy Volunteers
Start: Feb 12, 2019
Completion: Jun 21, 2019
NCT04208412
A Phase II, Cross-over Clinical Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) in the On-demand Treatment of Angioedema Attacks in Adult Subjects With Hereditary Angioedema Type I or II
Start: Jul 2, 2019
Completion: Dec 8, 2020
NCT05118958
Phase 1 Crossover Study in Healthy Subjects to Evaluate the PK Profile of KVD824 Following Single and Multiple Doses of Modified Release (MR) Formulations
Start: May 19, 2020
Completion: Dec 1, 2020
NCT05055258
A Trial to Evaluate the Efficacy and Safety of Different Doses of KVD824 for Prophylactic Treatment of HAE Type I or II
Start: Sep 27, 2021
Completion: Oct 27, 2022
NCT05259917
A Phase III, Crossover Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)
Phase: Phase 3
Start: Feb 22, 2022
Completion: Dec 31, 2023
NCT05505916
An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)
Start: Oct 24, 2022
Completion: Jun 30, 2026
NCT05511922
PK Subtrial in Adolescent Patients With HAE Type I or II Participating in the KVD900-302 Trial
NCT06467084
Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or II
Start: Jun 24, 2024
Completion: Aug 31, 2027
NCT07009262
A Study Observing US Patients With HAE Type I or II Who Take Icatibant to Treat HAE Attacks
Phase: N/A
Start: Apr 21, 2025
Completion: Apr 7, 2026
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