Small Molecules
Total Trials
21
As Lead Sponsor
20
As Collaborator
1
Total Enrollment
1,839
NCT01731353
FungiScope - A Global Emerging Fungal Infection Registry
Phase: N/A
Role: Collaborator
Start: Mar 31, 2003
Completion: Dec 31, 2026
NCT02142153
F901318 Single Ascending Dose Study in Healthy Male Volunteers
Phase: Phase 1
Role: Lead Sponsor
Start: Aug 31, 2014
Completion: Oct 31, 2014
NCT02342574
F901318 Multiple Ascending Dose Study
Start: Feb 28, 2015
Completion: Sep 30, 2016
NCT02394483
Single Ascending Oral Dose Study of F901318
Start: Oct 31, 2015
NCT02680808
Evaluation of the Potential for Cytochrome P450 3A4 Inhibition by F901318 Using Oral Midazolam as a Probe
Start: Jan 31, 2016
Completion: Jun 30, 2016
NCT02730442
Study of Potential for Interaction of Fluconazole With F901318
Start: Feb 29, 2016
NCT02737371
Multiple Ascending Oral Dose Study of F901318 in Healthy Subjects
Start: May 31, 2016
Completion: May 22, 2017
NCT02808741
Evaluation of Immediate Release Tablet
Start: Jul 31, 2016
Completion: Nov 30, 2016
NCT03036046
Safety and Pharmacokinetics of Oral F901318 (Fluconazole and Posaconazole) IN Aml Leukaemia
Phase: Phase 1/2
Start: Mar 31, 2017
Completion: Mar 31, 2018
NCT02856178
Study on Safety and Pharmacokinetics of Intravenous F901318 for Fungal Prophylaxis in AML Patients
Start: Apr 20, 2017
Completion: Apr 20, 2017
NCT03076905
Pharmacokinetics of IV Formulation
Start: May 31, 2017
Completion: Aug 31, 2017
NCT03095547
Drug/Drug Interactions With F901318
Completion: Oct 31, 2017
NCT03340597
Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects
Start: Dec 12, 2017
Completion: Apr 13, 2018
NCT03583164
Evaluate F901318 (Olorofim) Treatment of Invasive Fungal Infections in Participants Lacking Treatment Options
Phase: Phase 2
Start: Jun 6, 2018
Completion: Feb 10, 2023
NCT02912026
Radiolabelled IV and Oral Metabolism Study of F901318
Start: May 31, 2019
Completion: Jul 31, 2019
NCT04039880
Absorption, Metabolism and Excretion of 14C-olorofim in Man
Start: Jul 30, 2019
Completion: Sep 30, 2019
NCT04171739
Drug-drug Interaction (DDI) Study to Assess Effect of Itraconazole and Rifampicin Upon Olorofim
Start: Nov 18, 2019
Completion: Feb 11, 2020
NCT04207957
A Biopharmaceutics Study to Assess the Pharmacokinetics of Single Oral and IV Doses of Olorofim
Start: Dec 5, 2019
Completion: Sep 15, 2020
NCT04752540
A Phase I Study to Assess the Pharmacokinetics of Olorofim in Subjects With Hepatic Impairment
Start: Jul 2, 2021
Completion: Oct 24, 2021
NCT05200286
A Phase I Study to Assess the Pharmacokinetics of Olorofim in Subjects With Renal Impairment
Start: Feb 10, 2022
Completion: Dec 13, 2022
NCT05101187
Olorofim Aspergillus Infection Study
Phase: Phase 3
Start: Mar 31, 2022
Completion: Nov 1, 2026
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