Defunct Company
Total Trials
24
As Lead Sponsor
As Collaborator
0
Total Enrollment
5,143
NCT00877799
Study to Evaluate Analgesic Effect of Intravenous Administration of Kappa Agonist CR845 After Hysterectomy Surgery
Phase: Phase 2
Role: Lead Sponsor
Start: Mar 31, 2009
Completion: Jan 31, 2010
NCT01361568
Study to Evaluate Analgesic Effect of IV Administration of Kappa Agonist CR845 For Hysterectomy Surgery
Start: Jul 31, 2011
Completion: Apr 30, 2012
NCT01789476
A Phase 2 Study to Evaluate Analgesic Effect of IV CR845 For Pain Following Bunionectomy Surgery
Start: May 31, 2013
Completion: Aug 31, 2013
NCT02229929
Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pruritus
Start: Jul 31, 2014
Completion: Jul 31, 2015
NCT02524197
A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee
Start: Aug 31, 2015
Completion: Jan 31, 2016
NCT02542384
A Study Evaluating the Overall Pain Relief and Safety of Intravenous (IV) CR845 in Patients Undergoing Abdominal Surgery
Phase: Phase 2/3
Start: Sep 30, 2015
Completion: Jun 30, 2018
NCT02858726
Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
Start: Jun 30, 2016
Completion: Mar 14, 2017
NCT02944448
A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee
Start: Sep 30, 2016
Completion: Jun 30, 2017
NCT03281538
Extension Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
Phase: Phase 3
Start: Aug 14, 2017
Completion: Feb 11, 2020
NCT03422653
A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-1)
Start: Feb 20, 2018
Completion: Mar 26, 2020
NCT03617536
A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus
Start: Jul 5, 2018
Completion: Nov 14, 2019
NCT03636269
CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
Start: Jul 17, 2018
Completion: Mar 30, 2020
NCT03947970
Study to Evaluate the Pharmacokinetics and Metabolism of [14C] CR845 (Difelikefalin) in Patients With End Stage Renal Disease on Hemodialysis and in Healthy Subjects
Phase: Phase 1
Start: Jan 17, 2019
Completion: Apr 6, 2019
NCT03998163
CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
Start: May 6, 2019
Completion: Mar 6, 2020
NCT04019574
Study to Investigate the Effects of Single Intravenous Doses of Difelikefalin (CR845) on the QTc Interval in Healthy Subjects
Start: Jun 20, 2019
Completion: Oct 29, 2019
NCT03995212
Study to Evaluate the Safety and Efficacy of Oral CR845 (Difelikefalin) in Patients With Primary Biliary Cholangitis (PBC) and Moderate-to-Severe Pruritus
Start: Jun 25, 2019
Completion: Jun 29, 2022
NCT04018027
Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Atopic Dermatitis
Start: Jun 29, 2019
Completion: Apr 1, 2021
NCT05533008
CR845-100303: Study to Assess the Potential of Physical Withdrawal From Intravenous CR845 (Difelikefalin) in Hemodialysis Patients
Start: Dec 31, 2019
Completion: Jun 11, 2020
NCT04706975
Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica (KOMFORT)
Start: Jan 11, 2021
Completion: Jun 30, 2022
NCT05342623
A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus
Start: May 17, 2022
Completion: Feb 29, 2024
NCT05387707
Study to Evaluate the Efficacy and Safety of Oral Difelikefalin as Adjunct Therapy to a Topical Corticosteroid for Moderate to Severe Pruritus in Subjects With Atopic Dermatitis
Start: Aug 16, 2022
Completion: Feb 2, 2024
NCT05356403
CR845-310302: A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus
Start: Aug 26, 2022
Completion: Feb 26, 2024
NCT05978063
Study to Evaluate the Efficacy and Safety of Oral Difelikefalin for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica
Start: Aug 1, 2023
Completion: May 7, 2024