Sex-Specific Cerebrovascular Dysfunction in Metabolic Syndrome-Role of COX

"Indomethacin is a nonsteroidal anti-inflammatory. It prevents the production of prostaglandins, endogenous signaling molecules known to cause symptoms from inflammation.~Indomethacin (1.5 mg/kg) will be taken orally prior to one MRI study visit."

Participants will be screened for lactose intolerance. Total dosing will be calculated to match the mg needed for the indomethacin study visit.

CBF testing will be performed on 3T MRI scanners (GE Healthcare)