Neoadjuvant Complete Response Customized Treatment Approach for Definitive Management of Breast Cancer

Participants will receive standard of care neoadjuvant chemotherapy

Radiotherapy simulation parameters will be at the discretion of the treating physician to account for the patient's body habitus, tumor bed location, and tolerability of the prone or supine positions, however, the recommended approach will be whole-breast RT (WBRT) in the prone position, for cT1-3 N0 patients who achieve ecCR. For cT1-2 N1 patients who achieve ecCR WBRT with nodal inclusion and lymph node boost will be performed in the supine position.

Participants will undergo MRI

Participants will undergo surgery to treat their breast cancer. Either a lumpectomy or a mastectomy will be performed.

Participants undergo biopsy

Participants undergo blood and plasma collection