68
Participants
Start Date
November 1, 2025
Primary Completion Date
November 1, 2027
Study Completion Date
November 15, 2027
Ultrasound-Guided Interscalene Brachial Plexus Block
"Single 16 mL injection (15 mL 0.5 % bupivacaine + 1 mL dexamethasone 4 mg) at the C5-C6 root level under ultrasound guidance.~Performed pre-operatively as standard care for shoulder surgery. Arm Cross-Reference: Standard Interscalene Block (Control)"
Phrenic-Sparing Block Combination (Experimental)
"Infraclavicular: 15 mL (75 mg) 0.5 % bupivacaine + 1 mL dexamethasone (4 mg) injected around the cords of the brachial plexus beneath the clavicle under ultrasound guidance.~Distal Suprascapular: 12 mL (60 mg) 0.5 % bupivacaine + 1 mL (4 mg) dexamethasone injected at the suprascapular notch under ultrasound guidance to provide complete shoulder coverage while minimizing phrenic nerve involvement. Total local anesthetic dose = 135 mg bupivacaine + 8 mg dexamethasone.~Arm Cross-Reference: Phrenic-Sparing Block Combination (Experimental)"
Bupivacaine HCl 0.5% Injectable Solution
"Infraclavicular: Adminstered as 15 mL (75 mg) injection (together with dexamethasone).~Distal Suprascapular: Adminstered as 12 mL (60 mg) injection (together with dexamethasone)."
Dexamethasone 4mg
Adminstered as applicable for infraclavicular and distal suprascapular: as 1 mL (4 mg) injection (together with bupicacaine 0.5%).
University of North Carolina Hospitals, Chapel Hill
American Society of Regional Anesthesia
OTHER
University of North Carolina, Chapel Hill
OTHER