Got Doxy- 'Flipping the Script' on STI PEP

"Doxycycline monohydrate 200 mg (two 100 mg pills) is used to treat or prevent infections that are strongly suspected to be caused by bacteria. Doxycycline monohydrate is an antimicrobial drug indicated for the treatment of bacterial infections, including sexually transmitted diseases. CDC recommends its use as post-exposure prophylaxis (PEP).~Blood and rectal mucosal samples will be collected before the initiation of doxycycline. Participants will be instructed to take 200 mg of doxycycline by mouth every Monday, Wednesday, and Friday. Additional doses of doxycycline will be permitted on other days if sex without a condom occurs per CDC guidance. After 12 weeks of at least thrice weekly doxycycline, blood and rectal mucosal samples will again be collected for immunologic and microbiome/resistome assays."

Standard of care. Blood and rectal mucosal samples.