NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or Neuroblastoma

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

November 30, 2025

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2043

Conditions
Relapsed NeuroblastomaRefractory NeuroblastomaRelapsed OsteosarcomaRefractory Osteosarcoma
Interventions
GENETIC

i15.NKG2D.zeta NK cells and C7R.GD2.CARTs cells

Dose Level 1: 3 x 10\^8/m\^2 of i15.NKG2D.zeta NK cells and 3 x 10\^7/m\^2 of C7R.GD2.CAR T cells given 5 days later.

GENETIC

i15.NKG2D.zeta NK cells and C7R.GD2.CARTs cells

Dose Level 2: 6 x 10\^8/m\^2 of i15.NKG2D.zeta NK cells and 3 x 10\^7 cells/m\^2 of C7R.GD2.CAR T cells given 5 days later.

GENETIC

i15.NKG2D.zeta NK cells and C7R.GD2.CARTs cells

Dose Level 3: 12 x 10\^8/m\^2 of i15.NKG2D.zeta NK cells and 3 x 10\^7 cells/m\^2 of C7R.GD2.CAR T cells given 5 days later.

Trial Locations (1)

77030

Texas Children's Hospital, Houston

All Listed Sponsors
collaborator

Center for Cell and Gene Therapy, Baylor College of Medicine

OTHER

lead

Baylor College of Medicine

OTHER