18
Participants
Start Date
November 1, 2025
Primary Completion Date
December 31, 2027
Study Completion Date
June 1, 2028
Tests of sympathetic inhibition
Bolus phenylephrine infusion using the Oxford technique will generate the need to inhibit sympathetic activity. Similarly, resting state Mayer waves will be assessed with regard to heart rate and blood pressure responses.
Tests of above level sympathetic activation
Cold pressor test of the hand will be used to cause sympathetic activation. Valsalva's maneuver will assess the ability to buffer against blood pressure fall (phase II).
Testing of below level sympathetic activation
Cold pressor test of the foot and bladder pressor response will be tested.
RECRUITING
Mayo Clinic, Rochester
Lead Sponsor
The Craig H. Neilsen Foundation
OTHER
Mayo Clinic
OTHER