Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

NARecruitingINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

November 1, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

June 1, 2028

Conditions
Spinal Cord Injuries
Interventions
DIAGNOSTIC_TEST

Tests of sympathetic inhibition

Bolus phenylephrine infusion using the Oxford technique will generate the need to inhibit sympathetic activity. Similarly, resting state Mayer waves will be assessed with regard to heart rate and blood pressure responses.

DIAGNOSTIC_TEST

Tests of above level sympathetic activation

Cold pressor test of the hand will be used to cause sympathetic activation. Valsalva's maneuver will assess the ability to buffer against blood pressure fall (phase II).

DIAGNOSTIC_TEST

Testing of below level sympathetic activation

Cold pressor test of the foot and bladder pressor response will be tested.

Trial Locations (1)

55905

RECRUITING

Mayo Clinic, Rochester

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

The Craig H. Neilsen Foundation

OTHER

lead

Mayo Clinic

OTHER