Phase II Non-Randomized Study Evaluating POSLUMA-PSMA PET Response After Oligo- Metastatic/Progressive-directed Treatment With Radiotherapy (PROMPT-R)

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

October 11, 2025

Primary Completion Date

July 7, 2027

Study Completion Date

July 7, 2027

Conditions
Prostate Cancer
Interventions
DRUG

ADT

Androgen Deprivation Therapy

DRUG

ARSI

Androgen Receptor Signaling Inhibitor

OTHER

No ADT/ARSI -decline

Recurrent prostate cancer with oligometastatic disease who decline ADT/ARSI and are treated with ablative intent RT alone and who have \<=5 extrapelvic lesions detected on a baseline PSMA-PET and have rising PSA.

Trial Locations (1)

91010

City of Hope Medical Center, Duarte

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER