30
Participants
Start Date
July 31, 2025
Primary Completion Date
December 31, 2025
Study Completion Date
June 30, 2026
Intravenous infusion of mononuclear cells from umbilical cord blood
When performing cell infusion, it is essential to use an infusion set and follow the standard blood transfusion procedures. Before, during, and after the infusion, monitor the patient's body temperature, pulse, breathing, and blood pressure. When infusing cells, first flush the tube with 20-30 ml of 0.9% sodium chloride, and start the infusion at a rate of 20-30 drops per minute. After half an hour, if there are no adverse reactions, increase the rate to 30-50 drops per minute. During the cell infusion process, gently shake the cell bag once every 15 minutes. After the infusion is completed, flush the cell preservation bag with 20 ml of 0.9% sodium chloride and gently shake it. After that, use 0.9% sodium chloride to rinse the infusion set to remove the cells completely, to ensure the quantity of cell infusion.
Conventional medical treatment:donepezil, rivastigmine or galantamine
The treatment is carried out using drugs such as cholinesterase inhibitors (ChEI) which are suitable for mild to moderate Alzheimer's disease. For example, donepezil, rivastigmine, galantamine, etc. The frequency and dosage of drug administration should be in accordance with the instructions provided by the drug manufacturer.The patient should maintain the stability of the medication regimen throughout the entire study period.
RECRUITING
The First Affiliated Hospital of the University of Science and Technology of China, Hefei
Shandong Qilu Stem Cell Engineering Co., Ltd.
UNKNOWN
Anhui Provincial Hospital
OTHER_GOV