Epidural Electrical Stimulation in Spinal Cord Injury (T11-L3)

NARecruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

July 1, 2025

Primary Completion Date

December 30, 2026

Study Completion Date

December 30, 2026

Conditions
Spinal Cord Injuries (SCI)
Interventions
PROCEDURE

Epidural Electrical Stimulation

Epidural Electrical Stimulation (EES) is a medical technology that involves delivering controlled electrical impulses to the spinal cord through electrodes implanted in the epidural space-the area between the outermost membrane of the spinal cord (dura mater) and the vertebrae. This technique aims to modulate the activity of spinal neural networks, thereby regulating neurological functions and promoting functional recovery, particularly in individuals with spinal cord injuries or certain neurological disorders.

PROCEDURE

Standard Rehabilitation Therapy

A structured, multidisciplinary rehabilitation program designed to improve motor function, mobility, and independence in participants with paralysis. The therapy typically includes physical Therapy and occupational Therapy.

RADIATION

positron emission tomography-computed tomography (PET-CT)

PET-CT is an advanced hybrid imaging modality that combines metabolic information from positron emission tomography with anatomical details from computed tomography.

RADIATION

Diffusion Tensor Imaging (DTI)

DTI is an advanced MRI technique that maps white matter tracts by measuring the directionality (anisotropy) and magnitude of water molecule diffusion in neural tissues. It provides quantitative metrics of fibers.

PROCEDURE

Somatosensory Evoked Potentials (SEPs)

SEPs are electrophysiological responses recorded from the central or peripheral nervous system following electrical stimulation of sensory nerves. They assess the functional integrity of somatosensory pathways.

PROCEDURE

Motor Evoked Potentials (MEPs)

MEPs are electrophysiological responses elicited by transcranial magnetic stimulation or electrical stimulation of the motor cortex, recorded from peripheral muscles or the spinal cord. They evaluate the integrity of corticospinal tracts.

Trial Locations (1)

310009

RECRUITING

Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou

All Listed Sponsors
collaborator

College of Biomedical Engineering and Instrumentation Science, Zhejiang University

UNKNOWN

lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER